Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study
Open accessAbstract
Removal of the anterior temporal lobe (ATL) is an effective surgical treatment for intractable temporal lobe epilepsy but carries a risk of language and verbal memory deficits. Preoperative localization of functional zones in the ATL might help reduce these risks, yet fMRI protocols in current widespread use produce very little activation in this region. Based on recent evidence suggesting a role for the ATL in semantic integration, we designed an fMRI protocol comparing comprehension of brief narratives (Story task) with a semantically shallow control task involving serial arithmetic (Math task). The Story > Math contrast elicited strong activation throughout the ATL, lateral temporal lobe, and medial temporal lobe bilaterally in an initial cohort of 18 healthy participants. The task protocol was then implemented at 6 other imaging centers using identical methods. Data from a second cohort of participants scanned at these centers closely replicated the results from the initial cohort. The Story-Math protocol provides a reliable method for activation of surgical regions of interest in the ATL. The bilateral activation supports previous claims that conceptual processing involves both temporal lobes. Used in combination with language lateralization measures, reliable ATL activation maps may be useful for predicting cognitive outcome in ATL surgery, though the validity of this approach needs to be established in a prospective surgical series.
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In the language processing task contrast story versus math, robust group-level activation occurs in anterior and inferior temporal regions and ventral prefrontal regions typically associated with language processing.
“Figure 9 displays results from the language processing task developed by Binder et al. (2011), with the specific contrast being story processing versus math. These data are acquired in approximately 8 minutes, and show robust group level activation in anterior and inferior temporal regions, as well as ventral prefrontal regions typically associated with various components of language processing.”
From The WU-Minn Human Connectome Project: An overview (2013) · cites this paper as Binder et al. (2011)
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References 106 · Cited by 300
Research works printed but not linked: 1
- Coltheart M Colheart M Patterson K Marshall JC 1980 Deep dyslexia: A right hemisphere hypothesis Deep dyslexia Routledge and Kegan Paul London
- Authors
- Binder, J. R., Gross, W. L., Allendorfer, J. B., Bonilha, L., Chapin, J., Edwards, J. C., Grabowski, T. J., Langfitt, J. T., Loring, D. W., Lowe, M. J., Koenig, K., Morgan, P. S., Ojemann, J. G., Rorden, C., Szaflarski, J. P., Tivarus, M. E., & Weaver, K. E.
- Affiliations
- Medical College of Wisconsin (US)
- University of Cincinnati (US)
- Medical University of South Carolina (US)
- Cleveland Clinic (US)
- University of Washington (US)
- University of Rochester Medicine (US)
- Emory University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Binder, Jeffrey R.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 54
- Issue
- 2
- Pages
- 1465-1475
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2997157
- OpenAlex
- W2018254612
- Cited by
- 300
- References
- 106
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 25 · 2023: 26 · 2022: 27 · 2021: 24 · 2020: 26 · 2019: 17 · 2018: 24 · 2017: 12 · 2016: 15 · 2015: 9 · 2014: 11 · 2013: 17 · 2012: 15
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NINDS (R01 NS035929, R01 NS048281)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- anterior temporal lobe, language areas, semantic processing, narrative comprehension, temporal lobe epilepsy, preoperative language mapping, bilateral activation, language lateralization, verbal memory
- MeSH terms
- Adolescent, Adult, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Middle Aged, Temporal Lobe, Comprehension, Young Adult
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