CoChat
Sign Up
Cited by 34Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

Regional changes of cortical mean diffusivities with aging after correction of partial volume effects

Open access
Jeon, Tina, Mishra, Virendra, Uh, Jinsoo, Weiner, Myron, Hatanpaa, Kimmo J., White, Charles L., Zhao, Yan D., Lu, Hanzhang +2 more·2012·NeuroImage
DOI 10.1016/j.neuroimage.2012.05.082PMC PMC3574164
Open this paper in CoChat — free account

Abstract

Accurately measuring the cortical mean diffusivity (MD) derived from diffusion tensor imaging (DTI) at the comprehensive lobe, gyral and voxel level of young, elderly healthy brains and those with Alzheimer's disease (AD) may provide insights on heterogeneous cortical microstructural changes caused by aging and AD. Due to partial volume effects (PVE), the measurement of cortical MD is overestimated with contamination of cerebrospinal fluid (CSF). The bias is especially severe for aging and AD brains because of significant cortical thinning of these brains. In this study, we aimed to quantitatively characterize the unbiased regional cortical MD changes due to aging and AD and delineate the effects of cortical thinning of elderly healthy and AD groups on MD measurements. DTI and T1-weighted images of 14 young, 15 elderly healthy subjects and 17 AD patients were acquired. With the parcellated cortical gyri and lobes from T1 weighted image transformed to DTI, regional cortical MD of all subjects before and after PVE correction were measured. CSF contamination model was used to correct bias of MD caused by PVE. Compared to cortical MD of young group, significant increases of corrected MD for elderly healthy and AD groups were found only in frontal and limbic regions, respectively, while there were significant increases of uncorrected MD all over the cortex. Uncorrected MD are significantly higher in limbic and temporal gyri in AD group, compared to those in elderly healthy group but higher MD only remained in limbic gyri after PVE correction. Cortical thickness was also measured for all groups. The correlation slopes between cortical MD and thickness for elderly healthy and AD groups were significantly decreased after PVE correction compared to before correction while no significant change of correlation slope was detected for young group. It suggests that the cortical thinning in elderly healthy and AD groups is a significant contributor to the bias of uncorrected cortical MD measurement. The established comprehensive unbiased cortical MD profiles of young, elderly healthy subjects and AD patients at the lobe, gyral and voxel level may serve as clinical references for cortical microstructure.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2012.05.082

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 36

  1. Abe O Yamasue H Aoki S Suga m Yamada H Kasai K Masutani Y Kato N Kato N Ohtomo K Aging in the CNS: comparison of gray/white matter volume and diffusion tensor data Neurobiol. Aging 2008 29 102 116 17023094
  2. Alexander AL Hasan KM Lazar M Tsuruda JS Parker DL Analysis of partial volume effects in diffusion-tensor MRI Magn. Reson. Med 2001 45 770 780 11323803
  3. Anbeek P Vincken KL van Osch MJP Bisschops RHC van der Grond J Probabilistic segmentation of white matter lesions in MR imaging NeuroImage 2004 21 1037 1044 15006671
  4. Basser PJ Mattiello J LeBihan D MR diffusion tensor spectroscopy and imaging Biophys. J 1994 66 259 267 8130344 PMC1275686
  5. Benedetti B Charil A Rovaris M Judica E Valsasina P Sormani MP Filippi M Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI Neurology 2006 66 535 539 16505308
  6. Desikan RS Segonne F Fischl B Quinn BT Dickerson BC Blacker D Buckner RL Dale AM Maquire RP Hyman BT Albert MS Killiany RJ An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest NeuroImage 2006 31 968 980 16530430
  7. Falconer JC Narayana PA Cerebrospinal fluid-suppressed high-resolution diffusion imaging of human brain Magn. Reson. Med 1997 37 119 123 8978640
  8. Fischl B Dale AM Measuring the thickness of the human cerebral cortex from magnetic resonance images Proc. Natl. Acad. Sci. U. S. A 2000 97 11050 11055 10984517 PMC27146
  9. Fischl B van der Kouwe A Destrieux C Halgren E Segonne F Salat DH Busa E Seidman LJ Goldstein J Kennedy D Caviness V Makris N Rosen B Dale AM Automatically parcellating the human cerebral cortex Cereb. Cortex 2004 14 11 22 14654453
  10. Helenius J Soinne L Perkiö J Salonen Ol Kangasmäki A Kaste M Carano RAD Aronen HJ Tatlisumak T Diffusion-weighted MR imaging in normal human brains in various age groups Am. J. Neuroradiol 2002 23 194 199 11847041 PMC7975251
  11. Huang H Prince JL Mishra V Carass A Landman B Park DC Tamminga C King R Miller MI van Zijl PC Mori S A framework on surface-based connectivity quantification for the human brain J. Neurosci. Methods 2011 197 324 332 21396960 PMC3081907
  12. Jones DK Horsfield MA Simmons A Optimal strategies for measuring diffusing anisotropic systems by magnetic resonance imaging Magn. Reson. Med 1999a 42 515 525 10467296
  13. Kimmel R Sethian JA Computing geodesic paths on manifolds Proc. Natl. Acad. Sci. U. S. A 1998 95 8431 8435 9671694 PMC21092
  14. Koo BK Hua N Choi C Ronen I Lee J Kim D A framework to analyze partial volume effect on gray matter mean diffusivity measurements NeuroImage 2009 44 136 144 18775785
  15. Kwong KK McKinstry RC Chien D Crawley AP Pearlman JD Rosen BR CSF-suppressed quantitative single-shot diffusion imaging Magn. Reson. Med 1991 21 157 163 1943674
  16. Liu T Young G Huang L Chen NK Wong STC 76-space analysis of grey matter diffusivity: methods and applications NeuroImage 2006 31 51 65 16434215
  17. Malladi R Sethian JA An O(N log N) algorithm for shape modeling Proc. Natl. Acad. Sci. U. S. A 1996 93 9389 9392 8790339 PMC38437
  18. McKhann G Drachman D Folstein M Katzman R Price D Stadlan EM Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 1984 34 939 944 6610841
  19. Morris JC The Clinical Dementia Rating (CDR): current version and scoring rules Neurology 1993 43 2412 2414 8232972
  20. Moseley ME Diffusion tensor imaging and ageing — a review NMR Biomed 2002 15 553 560 12489101
  21. Moseley ME Cohen Y Kucharczyk J Mintorovitch J Asgari HS Wendland MF Tsuruda J Norman D Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system Radiology 1990 176 439 445 2367658
  22. Pasternak O Sochen N Gur Y Intrator N Assaf Y Free water elimination and mapping from diffusion MRI Magn. Reson. Med 2009 62 717 730 19623619
  23. Pierpaoli C Basser PJ Toward a quantitative assessment of diffusion anisotropy Magn. Reson. Med 1996 36 893 906 8946355
  24. Price JL Davis PB Morris JC White DL The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease Neurobiol. Aging 1991 12 295 312 1961359
  25. Ray KM Wang H Chu Y Chen YF Bert A Hasso AN Su MY Mild cognitive impairment: apparent diffusion coefficient in regional gray matter and white matter structures Radiology 2006 241 197 205 16990677
  26. Román GC Tatemichi TK Erkinjuntti T Cummings JL Masdeu JC Garcia JH Amaducci L Orgogozo JM Brun A Hofman A Moody DM O'Brien MD Yamaguchi T Grafman J Drayer BP Bennett DA Fisher M Ogata J Kokmen E Bermejo F Wolf PA Gorelick PB Bick KL Pajeau AK Bell MA DeCarli C Culebras A Korczyn AD Bogousslavsky J Hartmann A Scheinberg P Vascular dementia: diagnostic criteria for research studies. Report of NINDS-AIREN International Workshop Neurology 1993 43 250 260 8094895
  27. Salat DH Buckner RL Snyder AZ Greve DN Desikan RSR Busa E Morris JC Dale AM Fischl B Thinning of the cerebral cortex in aging Cereb. Cortex 2004 14 721 730 15054051
  28. Sethian JA A fast marching level set method for monotonically advancing fronts Proc. Natl. Acad. Sci. U. S. A 1996 93 1591 1595 11607632 PMC39986
  29. Shen D Davatzikos C HAMMER: hierarchical attribute matching mechanism for elastic registration IEEE Trans. Med Imaging 2002 21 1421 1439 12575879
  30. Silva MD Omae T Helmer KG Li F Fisher M Sotak CH Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain Magn. Reson. Med 2002 48 826 837 12417997
  31. Stahl R Dietrich O Teipel SJ Hampel H Reiser MF Schoenberg SO White matter damage in Alzheimer disease and mild cognitive impairment: assessment with diffusion-tensor MR imaging and parallel imaging techniques Radiology 2007 24 483 492 17456872
  32. Takahashi S Yonezawa H Takahashi J Kudo M Inoue T Tohgi H Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging Neurosci. Lett 2002 332 45 48 12377381
  33. Thompson PM Mega RS Woods RP Zoumalan CI Lindshield CJ Blanton RE Moussai J Holmes CJ Cummings JL Toga AW Cortical change in Alzheimer's disease detected with a disease-specific population-based brain atlas Cereb. Cortex 2001 11 1 16 11113031
  34. Westlye LT Walhovd KB Dale AM Due-Tonnessen P Engvig A Grydeland H Tamnes CK Obtby Y Fjell AM Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry Cereb. Cortex 2010 20 2055 2068 20032062
  35. Woods RP Grafton ST Holmes CJ Cherry SR Mazziotta JC Automated image registration: I. General methods and intrasubject, intramodality validation J. Comput. Assist. Tomogr 1998 22 139 152 9448779
  36. Zhang Y Schuff N Jahng GH Bayne W Mori S Schad L Mueller S Du AT Kramer JH Yaffe K Chui H Jagust WJ Miller BL Weiner MW Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease Neurology 2007 68 13 19 17200485 PMC1941719

Cited by

Sorted by citations

Authors
Jeon, T., Mishra, V., Uh, J., Weiner, M., Hatanpaa, K. J., White, C. L., Zhao, Y. D., Lu, H., Diaz-Arrastia, R., & Huang, H.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Huang, Hao
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2012-09
Volume
62
Issue
3
Pages
1705-1716
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2012.05.082
PMC
PMC3574164
OpenAlex
W1997085955
Cited by
34
References
3
Citations by year
2026: 4 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 4
FWCI
2.42
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (EB009545, 5UL1RR024982-02, MH092535, MH084021)
  • NIH/NIA (P30AG12300)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
brain aging, Alzheimer's disease, partial volume correction, cerebrospinal fluid contamination, cortical thinning, cortical thickness, diffusion tensor imaging, cortical microstructure, limbic cortex, frontal cortex, temporal cortex
MeSH terms
Aged, Aging, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Female, Humans, Image Interpretation, Computer-Assisted, Male, Young Adult, Diffusion Tensor Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review