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Cited by 72Advanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment ResearchAdvanced MRI Techniques and Applications

CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment

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Berlot, Rok, Metzler-Baddeley, Claudia, Jones, Derek K., O'Sullivan, Michael J.·2014·NeuroImage
DOI 10.1016/j.neuroimage.2014.01.031PMC PMC4010672
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Abstract

Diffusion MRI is used widely to probe microstructural alterations in neurological and psychiatric disease. However, ageing and neurodegeneration are also associated with atrophy, which leads to artefacts through partial volume effects due to cerebrospinal-fluid contamination (CSFC). The aim of this study was to explore the influence of CSFC on apparent microstructural changes in mild cognitive impairment (MCI) at several spatial levels: individually reconstructed tracts; at the level of a whole white matter skeleton (tract-based spatial statistics); and histograms derived from all white matter. 25 individuals with MCI and 20 matched controls underwent diffusion MRI. We corrected for CSFC using a post-acquisition voxel-by-voxel approach of free-water elimination. Tracts varied in their susceptibility to CSFC. The apparent pattern of tract involvement in disease shifted when correction was applied. Both spurious group differences, driven by CSFC, and masking of true differences were observed. Tract-based spatial statistics were found to be robust across much of the skeleton but with some localised CSFC effects. Diffusivity measures were affected disproportionately in MCI, and group differences in fornix microstructure were exaggerated. Group differences in white matter histogram measures were also partly driven by CSFC. For diffusivity measures, up to two thirds of observed group differences were due to CSFC. Our results demonstrate that CSFC has an impact on quantitative differences between MCI and controls. Furthermore, it affects the apparent spatial pattern of white matter involvement. Free-water elimination provides a step towards disentangling intrinsic and volumetric alterations in individuals prone to atrophy.

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  • Pasternak's approach has been found to reduce cerebrospinal fluid contamination and to improve diffusion measures in white matter fiber tracts.

    “Although Pasternak's approach has been found to reduce CSF contamination and to improve diffusion measures in white matter fiber tracts (Berlot et al., 2014, Metzler-Baddeley et al., 2012, Pasternak et al., 2009), a formal validation of this model is still missing.”

    From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Berlot et al., 2014

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Authors
Berlot, R., Metzler-Baddeley, C., Jones, D. K., & O'Sullivan, M. J.
Affiliations
  • King's College London (GB)
  • Cardiff University (GB)
Corresponding author
O'Sullivan, Michael J.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2014-05
Volume
92
Pages
27-35
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2014.01.031
PMC
PMC4010672
OpenAlex
W2050781164
Cited by
72
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 7
FWCI
9.39
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion, cc-by)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Funders
  • Medical Research Council, UK (G0701912)
  • Slovene Human Resources and Scholarship Fund
  • Wellcome Trust
  • NISCHR
  • Wellcome Trust Investigator
  • Wellcome Trust New Investigator Award
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
cerebrospinal fluid contamination, mild cognitive impairment, partial volume effect, white matter microstructure, tract-based spatial statistics, fornix, white matter atrophy, diffusion anisotropy
MeSH terms
Aged, Aged, 80 and over, Brain, Cerebrospinal Fluid, Female, Humans, Male, Nerve Fibers, Myelinated, Sensitivity and Specificity, Reproducibility of Results, Artifacts, Diffusion Tensor Imaging, Cognitive Dysfunction

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