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Cited by 100Ultrasound Imaging and ElastographyAdvanced MRI Techniques and ApplicationsMemory and Neural Mechanisms

Medial temporal lobe viscoelasticity and relational memory performance

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Schwarb, Hillary, Johnson, Curtis L., McGarry, Matthew D.J., Cohen, Neal J.·2016·NeuroImage
DOI 10.1016/j.neuroimage.2016.02.059PMC PMC4970644
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Abstract

Structural and functional imaging studies have been among converging lines of evidence demonstrating the importance of the hippocampus in successful memory performance. The advent of a novel neuroimaging technique - magnetic resonance elastography (MRE) - now makes it possible for us to investigate the relationship between the microstructural integrity of hippocampal tissue and successful memory processing. Mechanical properties of brain tissue estimated with MRE provide a measure of the integrity of the underlying tissue microstructure and have proven to be sensitive measures of tissue health in neurodegeneration. However, until recently, MRE methods lacked sufficient resolution necessary to accurately examine specific neuroanatomical structures in the brain, and thus could not contribute to examination of specific structure-function relationships. In this study, we took advantage of recent developments in MRE spatial resolution and mechanical inversion techniques to measure the viscoelastic properties of the human hippocampus in vivo, and investigated how these properties reflect hippocampal function. Our data reveal a strong relationship between relative elastic/viscous behavior of the hippocampus and relational memory performance (N=20). This is the first report linking the mechanical properties of brain tissue with functional performance.

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  • Altered mechanical properties have been associated with cognitive decline and occurrence of neurodegenerative diseases.

    “Altered mechanical properties have also been associated with cognitive decline and occurrence of neurodegenerative diseases (Pavuluri et al., 2025; Schwarb et al., 2016).”

    From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Schwarb et al., 2016

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Authors
Schwarb, H., Johnson, C. L., McGarry, M. D. J., & Cohen, N. J.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • Dartmouth College (US)
Corresponding author
  • Schwarb, Hillary
  • Johnson, Curtis L.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2016-05
Volume
132
Pages
534-541
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2016.02.059
PMC
PMC4970644
OpenAlex
W2279690205
Cited by
100
References
3
Citations by year
2026: 7 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 6 · 2014: 1
FWCI
9.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH/NIMH (R01-MH062500)
  • NIH/NIBIB (R01-EB018230, R01-EB001981)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampus, viscoelasticity, magnetic resonance elastography, relational memory, brain tissue mechanical properties, tissue microstructure, structure-function relationship, medial temporal lobe
MeSH terms
Adolescent, Adult, Brain Mapping, Elasticity, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Temporal Lobe, Diffusion Magnetic Resonance Imaging, Young Adult, Diffusion Tensor Imaging, Executive Function

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