Brain connectivity in normally developing children and adolescents
Abstract
The developing human brain undergoes an astonishing sequence of events that continuously shape the structural and functional brain connectivity. Distinct regional variations in the timelines of maturational events (synaptogenesis and synaptic pruning) occurring at the synaptic level are reflected in brain measures at macroscopic resolution (cortical thickness and gray matter density). Interestingly, the observed brain changes coincide with cognitive milestones suggesting that the changing scaffold of brain circuits may subserve cognitive development. Recent advances in connectivity analysis propelled by graph theory have allowed, on one hand, the investigation of maturational changes in global organization of structural and functional brain networks; and on the other hand, the exploration of specific networks within the context of global brain networks. An emerging picture from several connectivity studies is a system-level rewiring that constantly refines the connectivity of the developing brain.
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The period of synapse elimination and stabilization after birth in humans corresponds to late childhood.
“This corresponds to the period of synapse elimination and stabilization after birth in humans28,29, which may have significant implications for intervention.”
From Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism (2016) · cites this paper as [29]
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References 208 · Cited by 91
- Authors
- Khundrakpam, B. S., Lewis, J. D., Zhao, L., Chouinard-Decorte, F., & Evans, A. C.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Khundrakpam, Budhachandra S.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 134
- Pages
- 192-203
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2318288701
- Cited by
- 91
- References
- 208
- Citations by year
- 2025: 13 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 3
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Keywords
- brain connectivity, brain development, children, adolescents, structural connectivity, functional connectivity, graph theory, synaptogenesis, synaptic pruning, cortical thickness, gray matter density, cognitive development
- MeSH terms
- Adolescent, Aging, Brain, Child, Child, Preschool, Cognition, Computer Simulation, Female, Humans, Male, Models, Neurological, Nerve Net, Neural Pathways, Connectome
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