Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice
Hayashi, Mansuo L, Choi, Se-Young, Rao, B.S.Shankaranarayana, Jung, Hae-Yoon, Lee, Hey-Kyoung, Zhang, Dawei, Chattarji, Sumantra, Kirkwood, Alfredo +1 more·2004·Neuron
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- p21-Activated kinase 5: A pleiotropic kinaseYiyang Wen, Xiaoxia Wang, Dong‐Sheng Pei, Junnian Zheng · 2013 · Bioorganic & Medicinal Chemistry Letters
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- Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorderClaudia Fuchs, Livia Cosentino, Chiara Urbinati, Maria Cristina Talamo, Giorgio Medici, Maria Cristina Quattrini, Nicola Mottolese, Donatella Pietraforte, Andrea Fuso, Elisabetta Ciani et al. · 2022 · CNS Neuroscience & Therapeutics
- Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in miceXinran Ji, Wei Zhang, Lihai Zhang, Licheng Zhang, Yiling Zhang, Peifu Tang · 2014 · Brain Research
- BDNF local translation in viable synaptosomes: Implication in spine maturationKusumika Gharami, Sumantra Das · 2014 · Neurochemistry International
- Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic FunctionAngèle Parent, Gopal Thinakaran · 2010 · International Journal of Alzheimer s Disease
- PAK1 regulates inhibitory synaptic function via a novel mechanism mediated by endocannabinoidsShuting Xia, Zikai Zhou, Zhengping Jia · 2016 · Small GTPases
- The molecular and cellular basis of memory engrams: Mechanisms of synaptic and systems consolidationJanina Kupke, Ana M.M. Oliveira · 2025 · Neurobiology of Learning and Memory
- Steady‐state increase of cAMP‐response element binding protein, Rac, and PAK signaling in presenilin‐deficient neuronsNatalie Y. Barnes, Jun Shi, Hiroshi Yajima, Gopal Thinakaran, Angèle Parent · 2007 · Journal of Neurochemistry
- Cytoskeletal changes in diseases of the nervous systemAlexandra K. Suchowerska, Thomas Fath · 2014 · Frontiers in Biology
- Development of transcripts regulating dendritic spines in layer 3 pyramidal cells of the monkey prefrontal cortex: Implications for the pathogenesis of schizophreniaSamuel J. Dienel, H. Holly Bazmi, David A. Lewis · 2017 · Neurobiology of Disease
- Benzothiazole amphiphiles promote RasGRF1‐associated dendritic spine formation in human stem cell‐derived neuronsJessica L. Cifelli, Kyle R. Berg, Jerry Yang · 2020 · FEBS Open Bio
- ErratumDae-Weon Lee, Young-Ho Koh, Jong Bok Seo, Barry Ganetzky · 2009 · Molecules and Cells
- Neurodevelopmental disorders: 2022 updateMiguel Sabariego-Navarro, Álvaro Fernández‐Blanco, Cèsar Sierra, Mara Dierssen · 2022 · Free Neuropathology
- Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid HormoneYiqiao Wang, André Fisahn, Indranil Sinha, Dinh Phong Nguyen, Ulrich Sterzenbach, François Lallemend, Saïda Hadjab · 2016 · Scientific Reports
- Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition MemorySusan Zhou, Zhengping Jia · 2021 · Cells
- Bright light exposure advances consolidation of motor skill accuracy in humansTakuya Yoshiike, Motoyasu Honma, Hiroki Ikeda, Kenichi Kuriyama · 2019 · Neurobiology of Learning and Memory
- Grading Gradients: Evaluating Evidence for Time-dependent Memory Reorganization in Experimental AnimalsKatherine G. Akers, Paul W. Frankland · 2009 · Journal of Experimental Neuroscience
- The cleavage of host cell proteins by HIV-1 protease.Václav Snåšel, I. (Iva) Pichová · 1996 · PubMed
- Signaling Through Actin to Regulate Spine Formation and FunctionHirokazu Okada, Scott H. Soderling · 2014 · The Open Neuroscience Journal
- Involvement of Cdk5 in Synaptic Plasticity, and Learning and MemoryFlorian Plattner, Karl-Peter Giese, Marco Angelo · 2008 · Springer eBooks
- Neural Interfacing: Forging the Human-Machine ConnectionSusanne D. Coates · 2008 · Synthesis lectures on biomedical engineering
- Counteracting Molecular Pathways Regulating the Reduction of Fear: Implications for the Treatment of Anxiety DiseasesAndré Fischer, Li‐Huei Tsai · 2009 · Humana Press eBooks
- Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)Suneet Mehrotra, Marsha L. Pierce, Shashank Manohar Dravid, Thomas F. Murray · 2022 · Marine Drugs
- Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathwayJiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soo Hyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi et al. · 2022 · Molecular Psychiatry
- Molecular mechanisms mediating engram ensemble retrievability state in miceSungmo Park, Joseph Jonathan Lee, Asim J. Rashid, Chen Yan, Valentina Mercaldo, Alexander D. Jacob, Jung Hoon Jung, Paul W. Frankland, Sheena A. Josselyn · 2025 · Neuron
- Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred lineIris W. Riemersma, Kevin G.O. Ike, Thomas Sollie, Elroy L. Meijer, Robbert Havekes, Martien J. Kas · 2024 · Cerebral Cortex
- X-Linked ASDs and ID Gene MutationsEdoardo Moretto, Maria Passafaro, Silvia Bassani · 2016 · Elsevier eBooks
- The Role of the Postsynaptic Density and the Spine Cytoskeleton in Synaptic PlasticityEdoardo M. Marcora, Holly J. Carlisle, Mary B. Kennedy · 2008 · Elsevier eBooks
- [Impairment of social interaction, coordination disorder, and hypersensitivity in Asperger's syndrome].Tomoko T. Asai, Toshiro Sugiyam · 2007 · PubMed
- Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1Aashish Shivkumar, Kyle R. Berg, Kevin Carlo Abril Sibucao, Geoffray Leriche, Lara E. Dozier, Carla A. Espinoza, Gentry N. Patrick, Zied Gaieb, Christian G. Seitz, Rommie E. Amaro et al. · 2025 · Journal of Biological Chemistry
- Role of Central Insulin-Like Growth Factor-1 Receptor Signalling in Ageing and Endocrine RegulationLorna Moll, Johanna Zemva, M Schubert · 2011 · InTech eBooks
- Defects in Rho GTPase Signaling to the Spine Actin Cytoskeleton in FMR1 Knockout MiceJulie C. Lauterborn, Christine M. Gall · 2017 · Elsevier eBooks
- A computational model of current control mechanism for long‐term potentiation (LTP) in human episodic memory based on gene–gene interactionSudhakar Tripathi, Ravi Bhushan Mishra, Anand Bihari, Sanjay Agrawal, Puneet Joshi · 2023 · European Journal of Neuroscience
- Molecular Mechanisms of Dendritic Spine Plasticity in Development and AgingMichael R. Kreutz, Imbritt König, Marina Mikhaylova, Christina Spilker, Werner Zuschratter · 2008 · Springer eBooks
- Learning-induced enduring changes in inhibitory synaptic transmission in lateral amygdala are mediated by p21-activated kinaseBlesson K. Paul, Iris Reuveni, Edi Barkai, Raphael Lamprecht · 2019 · Journal of Neurophysiology
- Amphetamine-induced dopaminergic toxicity:Jobes, Michelle L. · 2008 · Rutgers University Community Repository (Rutgers University)
- Expressionsanalyse des murinen alphaPix/Arhgef6-Proteins und funktionelle Charakterisierung der alphaPix/Arhgef6-Knockout-MausKerstin Kuchenbecker · 2006
- Spine Morphology and Plasticity in X-linked Mental RetardationsJyothi Arikkath · 2014 · The Open Neuroscience Journal
- The role of p21-activated kinase in maintaining the fear learning-induced modulation of excitation/inhibition ratio in lateral amygdalaBlesson K. Paul, Edi Barkai, Raphael Lamprecht · 2021 · Neurobiology of Learning and Memory
- Connecting the DotsAnna Dunaevsky · 2004 · Neuron
- Synaptic Abnormalities and NeuroplasticityRuoqi Gao, Theron A. Russell, Peter Penzes · 2015 · Handbook of behavioral neuroscience
- Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and NeurodegenerationAndré Fischer, Li‐Huei Tsai · 2008 · Springer eBooks
- PAK1 in Alzheimer’s and Huntington’s DiseasesQiu‐Lan Ma, Fusheng Yang, Sally Ann Frautschy, Greg M. Cole · 2013 · Elsevier eBooks
- Distinct Roles of the Rho-GTPase Associated Kinases PAK and ROCK in the Regulation of Dendritic Spines and Synaptic PlasticitySuhail Asrar, Zhengping Jia · 2014 · The Open Neuroscience Journal
- The role of bHLH transcription factor NEX in neuronal differentiation and experience-dependent plasticityMikhailova, Olga · 2008
- Inhibiting circRNA Cdr1as expression in the ILPFC of adult male C57BL/6J mice impairs fear extinction memoryEsmi Lau Zajaczkowski, Qiongyi Zhao, Wei‐Siang Liau, Hao Gong, Sachithrani U. Madugalle, Ambika Periyakaruppiah, Laura Jane Leighton, Mason R. B. Musgrove, Haobin Ren, Joshua Davies et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Cellular mechanisms of synaptic plasticity in hippocampal area CA1Eric S. Guire · 2006
- Insulin Receptor and the Pathophysiology of Alzheimer DiseaseJohanna Zemva, M Schubert · 2013 · Wiley eBooks
- Methods for treating neurological conditions (WO2011159945)Wassilios G. Meissner · 2012 · Expert Opinion on Therapeutic Patents
- THE NITRIC OXIDE SYNTHASE ADAPTOR PROTEIN (NOS1AP) ASSOCIATES WITH SCRIBBLE AND REGULATES DENDRITIC SPINE DEVELOPMENTL. Richier · 2010 · Library and Archives Canada (Government of Canada)
- The neural cell adhesion molecule associates with and signals through p21-activated kinase 1 to regulate neuronal growth cone morphology in mice (Mus musculus Linnaeus, 1758)Shen Li · 2009
- RegulationofSynapticRac1Activity,Long-Term PotentiationMaintenance,andLearningandMemoryby BCRandABRRacGTPase-ActivatingProteinsOwen N. Witte, Louis Lim, Eunjoon Kim · 2010
- Synapse- and cell-specific plasticity in the mature hippocampusBridget N. Queenan · 2014 · DigitalGeorgetown (Georgetown University Library)
- Small GTP-binding Proteins: A Future for the Treatment of Cognitive Disorders?Maria Victoria Tejada-Simon · 2014 · Brain Disorders & Therapy
- Functions of Drosophila Pak (p21-activated kinase) in Morphogenesis: A Mechanistic Model based on Cellular, Molecular, and Genetic StudiesSara A. Lewis · 2015 · UA Campus Repository (The University of Arizona)
- Introduction: Pushing the Boundary Toward Clinical Application: After 35 Years, PAK Research Comes of AgeHiroshi Maruta · 2013 · Elsevier eBooks
- METAPLASTICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE AND POSSIBLE THERAPEUTIC INTERVENTIONSAndrea Megill · 2014
- The Role of PAK Signaling in Synaptic Transmission and Plasticity and Social Memory in MiceCeleste Leung · 2019 · TSpace (University of Toronto)
- Towards a Molecular and Cellular Understanding of Remote MemoryBrian Joseph Wiltgen, Robert A. M. Brown, Lynn E. Talton, Alcino J. Silva · 2007 · Research and perspectives in neurosciences
- Faculty Opinions recommendation of Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.Jamel Chelly · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Silent memory engrams as the basis for retrograde amnesia.Sheena A. Josselyn · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.Karl-Peter Giese · 2008 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndromeAmin Md Shakhawat, Jacqueline G Foltz, Adam B. Nance, Jaydev Bhateja, Jennifer L Raymond · 2023 · eLife
- Translational Pain Research: Dendritic Spines as Therapeutic TargetsCurtis A. Benson, Stephen G. Waxman, Andrew M. Tan · 2025 · Springer eBooks
- Second occurrence of the PAK3-R67C variation and multiscale analysis of the corresponding knock-in mice reveal novel phenotypic features and functional synaptic defectsManon Dobrigna, Sandrine Poëa‐Guyon, Mathieu Legras, Delphine Le Verger, Kévin Duarte, Catherine Sebrié, Roseline Poirier, Sylvie Granon, Serge Marty, Annick Toutain et al. · 2025 · Neurobiology of Disease
- Rôle de Scribble1 dans la formation des synapses glutamatergiques et le trafic des récepteurs NMDANicolas H. Piguel · 2010 · theses.fr (ABES)
- The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disordersVera Lúcia Margarido Pinheiro · 2014 · theses.fr (ABES)
- Etude de la neurogenèse hippocampique adulte et des fonctions cognitives chez trois souris modèles de déficience intellectuelleCharlotte Castillon · 2018 · theses.fr (ABES)
- Du génotype au phénotype : Analyse comparée de mutations du gène de déficience intellectuelle PAK3Kévin Duarte · 2019 · theses.fr (ABES)
- Etude moléculaire et fonctionnelle du gène PTCHD1 impliqué dans les troubles neurodéveloppementauxJudith Halewa · 2021 · theses.fr (ABES)
- Étude de la dysfonction du RhoGEF TRIO et son implication dans les troubles du neurodéveloppementMaxime Bonnet · 2022 · theses.fr (ABES)
- Étude multi-échelle de modèles murins de déficience intellectuelle associée à PAK3Manon Dobrigna · 2024
- Myosin IIB Maintains Long‐Term MemoryMateus Oliveira Silva, Lucas Marcondes Leite, Paula Santana Lunardi, Bruno Popik, Rossana Rosa Porto, Marina da Silva Medeiros, Lucas de Oliveira Alvares · 2026 · Hippocampus
- BindingDB Entry 50022520: Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.BindingDB · 2025 · UC San Diego
- Scalable Event-Driven Modelling Architectures for Neuromimetic HardwareAlexander D. Rast · 2011 · OpenGrey (Institut de l'Information Scientifique et Technique)
- Genetic Manipulation of Learning and MemoryJane Dunning · 2006 · Elsevier eBooks
- Rho-Linked Mental Retardation GenesNael Nadif Kasri, Linda Van Aelst · 2010 · Advances in neurobiology