Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration

Yazawa, Ikuru, Giasson, Benoit I., Sasaki, Ryogen, Zhang, Bin, Joyce, Sonali, Uryu, Kunihiro, Trojanowski, John Q., Lee, Virginia M.-Y.·2005·Neuron

Cited by (301)

Items 201–300 of 301

  1. Update of atypical parkinsonian disorders
    Irene Litvan · 2007 · Current Opinion in Neurology
  2. Alpha-synuclein transgenic mice: Relevance to multiple system atrophy
    Gwenaëlle Fillon, Philipp J. Kahle · 2005 · Movement Disorders
  3. Selective Nuclear Shrinkage of Oligodendrocytes Lacking Glial Cytoplasmic Inclusions in Multiple System Atrophy: A 3-Dimensional Volumetric Study
    Naoto Uyama, Toshiki Uchihara, Yoko Mochizuki, Ayako Nakamura, Ryōsuke Takahashi, Toshio Mizutani · 2009 · Journal of Neuropathology & Experimental Neurology
  4. Translational therapies for multiple system atrophy: Bottlenecks and future directions
    Stefanova, Nadia · 2018 · Autonomic Neuroscience
  5. cVEMP correlated with imbalance in a mouse model of vestibular disorder
    Reina Oshino, Nobutaka Ohgami, Tingchao He, Kyoko Ohgami, Xiang Li, Masashi Kato · 2019 · Environmental Health and Preventive Medicine
  6. Viral alpha-synuclein knockdown prevents spreading synucleinopathy
    Sindhu A. Menon, Rikke Hahn Kofoed, Fadl Nabbouh, Kristiana Xhima, Yasmeen Al-Fahoum, Tammy Langman, Howard T.J. Mount, Lamya S. Shihabuddin, S. Pablo Sardi, Paul E. Fraser et al. · 2021 · Brain Communications
  7. The ‘α-synucleinopathy syndicate’: multiple system atrophy and Parkinson’s disease
    Jeswinder Sian‐Hülsmann, Peter Franz Riederer · 2023 · Journal of Neural Transmission
  8. Nerve-Glial antigen 2: unmasking the enigmatic cellular identity in the central nervous system
    Marta Bottero, Giada Pessina, Caterina Bason, Tiziana Vigo, Antonio Uccelli, Giovanni Battista Ferrara · 2024 · Frontiers in Immunology
  9. Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes
    Ye-Seul Yoon, Woo Jung Ahn, Diadem Ricarte, Darlene Mae Ortiz, Chan Young Shin, Seung‐Jae Lee, He-Jin Lee · 2020 · Biomolecules & Therapeutics
  10. Potential neuron‐autonomous Purkinje cell degeneration by 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments
    Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min‐Young Song, Da Kyeong Park, Yuna Oh, Ju-Yeon Jo, Yoon Kyung Shin, Sung Joong Lee et al. · 2020 · The FASEB Journal
  11. Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy
    Christine Lund Kragh, Amanda M. Gysbers, Edward M. Rockenstein, Karen Murphy, Glenda Margaret Halliday, Eliezer Masliah, Poul Henning Jensen · 2013 · Neurobiology of Disease
  12. In vivo models of multiple system atrophy
    Pierre‐Olivier Fernagut, Imad Ghorayeb, Elsa Diguet, François Tison · 2005 · Movement Disorders
  13. α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis
    Zhengxin Ying, Fankai Lin, Weihong Gu, Yang Su, Abida Arshad, Hong Qing, Yulin Deng · 2011 · Journal of Neural Transmission
  14. Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise
    Reina Oshino, Nobutaka Ohgami, Tingchao He, Xiang Li, Masashi Kato, Masayoshi Kobayashi, Yishuo Gu, Kanako Komuro, Charalampos E. Angelidis, Masashi Kato · 2019 · Archives of Toxicology
  15. A Mouse Model of Multiple System Atrophy: Bench to Bedside
    Nadia Stefanova · 2022 · Neurotherapeutics
  16. Toward disease modification in multiple system atrophy: Pitfalls, bottlenecks, and possible remedies
    Florian Krismer, Klaus Seppi, Nadia Stefanova, Gregor Karl Wenning · 2016 · Movement Disorders
  17. Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ 42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice
    Shuo Xiao, Linlin Song, Jiangtao Li, He Wang, Na Yu, Ziqi Wang, Ying Zhang, Jinsheng He, Tao Hung · 2019 · Journal of Alzheimer s Disease
  18. Body-first Parkinson’s disease and variant Creutzfeldt–Jakob disease – similar or different?
    Amanda L. Woerman, Gültekin Tamgüney · 2022 · Neurobiology of Disease
  19. β-III Tubulin Fragments Inhibit α-Synuclein Accumulation in Models of Multiple System Atrophy
    Y. Suzuki, Cheng Hua Jin, Tamaki Iwase, Ikuru Yazawa · 2014 · Journal of Biological Chemistry
  20. Animal Models of Movement Disorders
    Susan Duty, Peter G. Jenner · 2017 · Springer eBooks
  21. Limitations and Applications of Rodent Models in Tauopathy and Synucleinopathy Research
    Emma Szegvari, Sara A. M. Holec, Amanda L. Woerman · 2025 · Journal of Neurochemistry
  22. A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu‐ichi Matsuzawa, Ryōsuke Takahashi, Hodaka Yamakado · 2024 · Molecular Brain
  23. Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes
    Jens Tank, Andrey C. da Costa Gonçalves, Ilona Kamer, Fatimunnisa Qadri, Kiren K. Ubhi, Edward M. Rockenstein, André Diedrich, Eliezer Masliah, Volkmar Groß, Jens Jordan · 2014 · Physiological Reports
  24. Regulation of the Mouse Na+-Dependent Glutamate/Aspartate Transporter GLAST: Putative Role of an AP-1 DNA Binding Site
    María-Guadalupe Ramírez-Sotelo, Esther López‐Bayghen, Luisa C. Hernández‐Kelly, José‐Antonio Arias‐Montaño, Alfonso Martín-Bernabé, Arturo Ortega · 2006 · Neurochemical Research
  25. Oligodendrocyte-Specific STAT5B Overexpression Ameliorates Myelin Impairment in Experimental Models of Parkinson’s Disease
    Yibo Li, Zhaowen Su, Jitong Zhai, Qing Liu, Hongfang Wang, Jiaxin Hao, Xiaofeng Tian, Jiamin Gao, Dandan Geng, Lei Wang · 2025 · Cells
  26. Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases
    Constanza J. Cortés, Albert R. La Spada · 2014 · Rare Diseases
  27. Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic
    Vivek P. Chavda, Chirag Amrutlal Patel, Dharti H. Modh, Yavuz Nuri Ertaş, Shreya S. Sonak, Nafesa K. Munshi, Krishnan Anand, Arun Soni, Sonal Vijay Pande · 2022 · Current Drug Metabolism
  28. Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects
    Qiuyi Lv, Yuxin Pan, Xing Chen, Jingpei Wei, Wei Wang, Hua Zhang, Jifeng Wan, Shiqiang Li, Yan Zhuang, Baolin Yang et al. · 2022 · Frontiers in Psychiatry
  29. Intercellular miscommunication in polyglutamine pathogenesis
    Christopher A. Ross, Don W. Cleveland · 2006 · Nature Neuroscience
  30. Motoneuron Disease: Basic Science
    Hristelina S. Ilieva, Nicholas John Maragakis · 2017 · Advances in neurobiology
  31. Quantitative Cellular Changes in the Thalamus of Patients with Multiple System Atrophy
    Tanya R. Vigen, Tomasz Brudek, Bente Pakkenberg, Mikkel Vestergaard Olesen · 2021 · Neuroscience
  32. Efficacy of Human Umbilical Cord Blood-Mononuclear Cell Transplantation for MSA Treatment and Its Effects on Changes in T-Cell Subsets in Peripheral Blood and Inflammatory Factors
    Haiyan Yu, Xiaoling Yuan, Min Zhao, Weifei Wang, Dianrong Gong · 2021 · Disease Markers
  33. Treatment of multiple system atrophy - the past, present and future.
    Haiyan Yu, Xiaoling Yuan, Lifeng Liu, Tian Wang, Dianrong Gong · 2018 · Europe PMC (PubMed Central)
  34. Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy
    Makoto Timon Tanaka, Yasuo Miki, Tomoya Kon, Fumiaki Mori, Koichi Wakabayashi · 2025 · Cells
  35. The Bac Transgenic Approach to Study Parkinson's Disease in Mice
    X. William Yang, Xiao‐Hong Lu · 2008 · Elsevier eBooks
  36. Fine epitope mapping of monoclonal antibodies specific to human α-synuclein
    Ju‐Youn Choi, Hyo‐Jin Park, Young-Mo Seong, Eui Yul Choi, Byung‐Re Min, Hyangshuk Rhim · 2005 · Neuroscience Letters
  37. Pathogenesis of multiple system atrophy
    Takafumi Hasegawa, Akio Kikuchi, Atsushi Takeda · 2013 · Neurology and Clinical Neuroscience
  38. Imaging in Neurology Research II: PET Imaging of CNS Disorders
    Gjermund Henriksen, Alexander E. Drzezga · 2010 · Springer eBooks
  39. Multiple System Atrophy
    Thomas Klockgether · 2009 · Springer eBooks
  40. Animal models of Parkinson’s disease and related disorders
    Giselle Maria Petzinger, Michael Walter Jakowec · 2013 · CRC Press eBooks
  41. L-dopa response pattern in a rat model of mild striatonigral degeneration
    Christine Kaindlstorfer, Nadia Stefanova, Joanna García, Florian Krismer, Máté Daniel Döbrössy, Georg Göbel, Kurt A. Jellinger, Roberta Granata, Gregor Karl Wenning · 2019 · PLoS ONE
  42. Chapter 8 α-Synuclein and Synucleinopathies
    Michael G. Schlossmacher · 2007 · Blue books of neurology
  43. Oligodendrocytes, the Forgotten Target of Gene Therapy
    Yasemin Ozgür-Gunes, Catherine Le Stunff, Pierre F Bougneres · 2024 · Cells
  44. Modeling synucleinopathies in rodents
    Anna Barber Janer, Eline Vonck, Veerle Baekelandt · 2021 · International review of movement disorders
  45. Modelling progressive autonomic failure in MSA: where are we now?
    Sylvia Stemberger, Gregor Karl Wenning · 2011 · Journal of Neural Transmission
  46. Parkinsonism-Plus Syndromes and Secondary Parkinsonian Disorders
    Stanley Fahn, Joseph J. Jankovic, Mark Hallett, Peter G. Jenner · 2007 · Elsevier eBooks
  47. Aetiopathogenesis
    K. A. Jellinger, Florian Krismer · 2013 · Springer eBooks
  48. Synaptic Density Reductions in MSA : A Potential Biomarker Identified Through [ 18F ] SynVesT ‐1 PET Imaging
    Jian Li, Daji Chen, Yongxiang Tang, Chen Zhao, Ming Sheng Zhou, Linlin Wan, Ling Xiao, You Fu, Zhiyou He, Zhichao Tang et al. · 2025 · Annals of Neurology
  49. Anti-TLR2 immunotherapy modulates neuron-to-oligodendrocyte propagation of α-synuclein in mouse and human models
    Eun-Jin Bae, Sangwoo Ham, Yeonwoo William Jeong, Woo Seung Yang, Jimin Shin, Won-Jae Lee, Woo Jung Ahn, Ye-Seul Yoon, He-Jin Lee, Sang Hwan Lee et al. · 2026 · Nature Communications
  50. Multiple system atrophy
    Roberta Granata, Gregor Karl Wenning · 2011 · Cambridge University Press eBooks
  51. Atypical parkinsonism, parkinsonism-plus syndromes and secondary parkinsonian disorders
    Joseph J. Jankovic, Mark Hallett, Michael S. Okun, Cynthia Comella, Stanley Fahn, Jennifer G. Goldman · 2021 · Elsevier eBooks
  52. Alpha-Synuclein and the Immune Response in Parkinson’s Disease
    Cintia Roodveldt, Adahir Labrador‐Garrido, Guillermo Izquierdo, David Pozo · 2011 · InTech eBooks
  53. Upregulation of α-synuclein expression in the rat cerebellum in experimental hepatic encephalopathy
    I. Suárez, Guillermo Bodega, Benjamı́n Fernández · 2010 · Neuropathology and Applied Neurobiology
  54. Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
    Stanley Fahn, Joseph J. Jankovic, Mark Hallett · 2011 · Elsevier eBooks
  55. Animal Models
    Nadia Stefanova · 2013 · Springer eBooks
  56. Neuropathology of Movement Disorders
    K. A. Jellinger · 2011 · Elsevier eBooks
  57. Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges
    Alain Ndayisaba, Marcos Herrera-Vaquero, Gregor Karl Wenning, Nadia Stefanova · 2019 · Clinical Autonomic Research
  58. Transgenic Animal Models of Proteinopathies
    Naruhiko Sahara, Heather L. Melrose, Simon D’Alton, Jada M. Lewis · 2011
  59. Etiology, Pathology, and Pathogenesis
    Felix Geser, K. A. Jellinger, Martin Köllensperger, Nadia Stefanova, Gregor Karl Wenning · 2009 · Blue books of neurology
  60. Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy
    Sam Chi-Hao Liu, Koping Chang, Meng‐Ling Chen, Ming‐Che Kuo, Teh-Cheng Wang, Ruey‐Meei Wu · 2025 · Acta Neuropathologica Communications
  61. Plasma Neurofilament Light Chain as a Biomarker for Motor Progression and Disease Milestones in Multiple System Atrophy: An Updated Prospective Cohort Study
    Jingxuan Huang, Lingyu Zhang, Qirui Jiang, Shichan Wang, Yi Xiao, Ning-Ning Che, Junyu Lin, Bi Zhao, Yangfan Cheng, Chunyu Li et al. · 2026 · Movement Disorders
  62. α-Synuclein overexpression increases the tropism of pre-formed fibrils and MSA-patient derived seeds towards oligodendroglia
    Anne-Line Strange Laursen, Frida Lind‐Holm Mogensen, Jonas Folke, Marie Frederikke Garnæs, Luisa Harriet Knecht, Tomasz Brudek, Mikkel Vestergaard Olesen, Marlene Bidstrup, Sanne Simone Kaalund, Susanne Holst-Williams et al. · 2026 · Acta Neuropathologica Communications
  63. Protein-First, but Not Protein-Only: Rethinking Neurodegenerative Diseases Through Transgenic Mouse Models
    Chih‐Wei Zeng · 2026 · Neurology International
  64. Modeling synucleinopathies in genetically modified animals: Successes and failures
    Natalia N. Ninkina, A. A. Ustyugov, Vladimir L. Buchman · 2008 · Molecular Biology
  65. Animal Models of Multiple-System Atrophy
    Florian Krismer, Daniela Kuzdas-Wood, Carlo Colosimo, Nadia Stefanova, Gregor Karl Wenning · 2014 · Elsevier eBooks
  66. Genetic Models of Familial Parkinson's Disease
    Mingyao Ying, Valina Lynn Dawson, Ted M. Dawson · 2008 · Elsevier eBooks
  67. Glial response to polyglutamine-mediated stress
    Parminder J. S. Vig, Qingmei Shao, Maripar E. Lopez · 2009 · Bioscience hypotheses
  68. Chapter 3 Multiple System Atrophy
    Felix Geser, Christoph Globas, Ludger J. Schöls, Gregor Karl Wenning · 2007 · Blue books of neurology
  69. The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
    Andreu Viader · 2011 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  70. Animal Models of Neurodegenerative Diseases
    Imad Ghorayeb, Guylène Page, Afsaneh Gaillard, Mohamed Jaber · 2010 · Advances in neurobiology
  71. Multiple system atrophy
    Sylvia Stemberger, Gregor Karl Wenning · 2011 · Cambridge University Press eBooks
  72. Disorders with Synuclein Pathology and P arkinsonism
    Laura Luisa Kilarski, Wei Jia Zhang, Huw R. Morris · 2018 · Encyclopedia of Life Sciences
  73. Preface – Special issue: Multiple system atrophy
    Carlo Colosimo, Sid Gilman, Niall Patrick Quinn, Gregor Karl Wenning · 2005 · Journal of Neural Transmission
  74. Promoting oligodendrocyte progenitor cell maturation and remyelination as a novel therapeutical approach for multiple system atrophy
    2015 · Therapeutic Targets for Neurological Diseases
  75. The role of alpha-synuclein phosphorylation in synucleinopathies
    Elisa Basso · 2014 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  76. A pathological investigation of the frontal lobe in post-stroke dementia and other ageing-related dementias
    Vincent Foster · 2015
  77. Combination Lesion Models of MSA
    Daniela Kuzdas-Wood, Gregor Karl Wenning · 2011 · Neuromethods
  78. Model Organisms and Neurogenetics
    David E. Krantz, George R. Jackson · 2007 · Medical psychiatry
  79. Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies
    Michel Goedert · 2017 · Neurodegeneration
  80. Sporadic Degenerative Ataxias and the Dominantly Inherited Spinocerebellar Ataxias
    Thomas Klockgether · 2009 · Elsevier eBooks
  81. Papers of Note
    2005 · Science of Aging Knowledge Environment
  82. Disorders with Synuclein Pathology and Parkinsonism
    Laura Luisa Kilarski, Vladimir L. Buchman, Huw R. Morris · 2009 · Encyclopedia of Life Sciences
  83. Animal models of Parkinson’s disease and related disorders
    Giselle Maria Petzinger, Michael Walter Jakowec · 2013 · Informa Healthcare eBooks
  84. Disorders with Synuclein Pathology and P arkinsonism
    Laura Luisa Kilarski, Wei Jia Zhang, Huw R. Morris · 2019 · Encyclopedia of Life Sciences
  85. Faculty Opinions recommendation of Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.
    Alfonso A. Fasano, David Breen · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  86. Animal Models and the Pathogenesis of Parkinson's Disease
    José G. Castaño, Teresa Iglesias, Justo Garcı́a de Yébenes · 2011 · Royal Society of Chemistry eBooks
  87. Fokus atypische Parkinsonsyndrome: Teil 1 – Multisystematrophie
    Clemens Jacksch, Steffen Paschen, Daniela Berg · 2023 · DGNeurologie
  88. Preclinical Validation of FTY720 and FTY720-Mitoxy in Mouse Models of Parkinsons Disease and Multiple System Atrophy (MSA): Evidence for Treating Lewy Body Disease Synucleinopathies Including MSA
    Guadalupe Vidal-Martínez, Haiyan Lou, Ruth G. Perez · 2024 · IntechOpen eBooks
  89. Additional file 4 of A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Maki, Takakuni, Matsuzawa, Shu-ichi, Takahashi, Ryosuke, Hodaka Yamakado · 2024 · Figshare
  90. Additional file 3 of A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Maki, Takakuni, Matsuzawa, Shu-ichi, Ryōsuke Takahashi, Hodaka Yamakado · 2024 · Figshare
  91. Additional file 1 of A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Maki, Takakuni, Matsuzawa, Shu-ichi, Takahashi, Ryosuke, Hodaka Yamakado · 2024 · Figshare
  92. Additional file 5 of A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Maki, Takakuni, Matsuzawa, Shu-ichi, Takahashi, Ryosuke, Hodaka Yamakado · 2024 · Figshare
  93. Additional file 2 of A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
    Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Maki, Takakuni, Matsuzawa, Shu-ichi, Takahashi, Ryosuke, Hodaka Yamakado · 2024 · Figshare
  94. Extracellular vesicle α-synuclein seeds drive divergent phenoconversion from iRBD to Parkinsonism
    Jun Liu, Fengqian Chen, Yan Shen, Hui Dong, Shenqing Zhang, Haonan Xiao, Ziyuan Liu, 王春毅, Mingyang Wei, Shengyuan Zhou et al. · 2026 · Research Square
  95. Étude moléculaire de la propagation de l’agrégation de l’alpha-synucléine dans un modèle transgénique de la maladie de Parkinson : impact de la surexpression de la beta-synucléine à l’aide de vecteurs viraux adéno-associés (AAV)
    Dorian Sargent · 2018 · theses.fr (ABES)
  96. Modélisation et recherche de stratégies expérimentales dans l’atrophie multisystématisée
    Paul A. Guerin · 2018
  97. Etude du rôle des altérations des cycles éveil/sommeil dans la progression de la maladie de Parkinson et de l'atrophie multisystématisée
    Marine Persillet · 2021
  98. Systemic delivery of anti-sense oligonucleotide targeting α-synuclein for treatment in a mouse model of multiple system atrophy
    Brian J. Spencer, Bao Quach, Sahar N Salehi, Robert A. Rissman · 2026 · Frontiers in Aging Neuroscience
  99. Propagation of α-synuclein pathology: models, mechanisms and future goals
    Aryeh Zolin, Sarah A. Weber, Yan Xin Xie, Jacqueline Burré · 2026 · Molecular Neurodegeneration Advances
  100. Multiple System Atrophy: Animal Models
    Nadia Stefanova · 2010 · Elsevier eBooks