Apoer2: a reelin receptor to remember
Open accessAbstract
The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic plasticity and to favor memory formation. This activity is carried out exquisitely by the Apoer2 receptor and critically requires the presence of an alternatively spliced exon. This exon encodes an intracellular domain that interacts with postsynaptic proteins and promotes binding and phosphorylation of NMDA receptors.
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ApoER2 is required for the maintenance of proper synaptic function in adulthood.
“ApoER2 is also required for the maintenance of proper synaptic function in adulthood (D'Arcangelo, 2005).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as D'Arcangelo, 2005
The Main Text (page not given) reports that the exon 19-containing form of ApoER2 is important for Reelin-dependent synaptic plasticity and learning in the adult brain. It does not establish that ApoER2 maintains proper synaptic function generally; the paper says whether Reelin regulates synapse stability remains to be studied. (LLM, conf=0.84)
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Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916 · see citing works
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works
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Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works
The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons
Niu, S., Yabut, O., & D'Arcangelo, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1917-08.2008 · Cited by 266 · see citing works
Self-citationDifferential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus
Qiu, S., Zhao, L. F., Korwek, K. M., & Weeber, E. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2561-06.2006 · Cited by 186 · see citing works
Gao, J., Marosi, M., Choi, J., Achiro, J. M., Kim, S., Li, S., Otis, K., Martin, K. C., Portera-Cailliau, C., & Tontonoz, P. (2017) · eLife · doi:10.7554/elife.29178 · Cited by 30 · see citing works
Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Larios, J. A., Jausoro, I., Benitez, M.-L., Bronfman, F. C., & Marzolo, M.-P. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-108 · Cited by 12 · see citing works
- Authors
- D’Arcangelo, G.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- D’Arcangelo, Gabriella
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 47
- Issue
- 4
- Pages
- 471-473
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2000544958
- Cited by
- 62
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 6
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- reelin, synaptic plasticity, memory formation, alternative splicing, NMDA receptor phosphorylation, postsynaptic proteins, neuronal positioning, brain development
- MeSH terms
- Reelin Protein, Animals, Brain, Humans, Nerve Tissue Proteins, Neuronal Plasticity, Phosphorylation, Protein Binding, Serine Endopeptidases, Synapses, Cell Adhesion Molecules, Neuronal, Receptors, N-Methyl-D-Aspartate, Extracellular Matrix Proteins, Alternative Splicing, Receptors, Lipoprotein, LDL-Receptor Related Proteins
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