Promiscuous interactions between AMPA-Rs and MAGUKs.
Open accessAbstract
What controls the number of AMPA receptors at excitatory synapses? MAGUKs are known to play a critical role in this process, but which ones are involved and when has been contentious. In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons.
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PSD-95 is a key determinant of synaptic levels of AMPARs.
“Accordingly, PSD-95 is a key determinant of synaptic levels of AMPARs [21],[22].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [22]
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Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
Barros, C. S., Calabrese, B., Chamero, P., Roberts, A. J., Korzus, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S., & Müller, U. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900355106 · Cited by 197 · see citing works
A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis
Boersma, M. C. H., Dresselhaus, E. C., De Biase, L. M., Mihalas, A. B., Bergles, D. E., & Meffert, M. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2456-10.2011 · Cited by 168 · see citing works
Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD
Han, K., Kim, M.-H., Seeburg, D., Seo, J., Verpelli, C., Han, S., Chung, H. S., Ko, J., Lee, H. W., Kim, K., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000187 · Cited by 71 · see citing works
- Authors
- Fitzjohn, S. M., Doherty, A. J., & Collingridge, G. L.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Fitzjohn, Stephen M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 52
- Issue
- 2
- Pages
- 222-224
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1993410515
- Cited by
- 19
- References
- 0
- Citations by year
- 2026: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2481 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- AMPA receptors, PSD-95, PSD-93, synaptic targeting, excitatory synapses, hippocampal neurons, synaptic plasticity, postsynaptic scaffolds
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Hippocampus, Humans, Membrane Proteins, Synaptic Transmission, Neuropeptides, Synapses, Down-Regulation, Receptors, AMPA, Protein Transport, Intracellular Signaling Peptides and Proteins, Guanylate Kinases
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