The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Open accessAbstract
Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc). We find that cocaine regulates myocyte enhancer factor 2 (MEF2) transcription factors to control these two processes in vivo. Cocaine suppresses striatal MEF2 activity in part through a mechanism involving cAMP, the regulator of calmodulin signaling (RCS), and calcineurin. We show that reducing MEF2 activity in the NAc in vivo is required for the cocaine-induced increases in dendritic spine density. Surprisingly, we find that increasing MEF2 activity in the NAc, which blocks the cocaine-induced increase in dendritic spine density, enhances sensitized behavioral responses to cocaine. Together, our findings implicate MEF2 as a key regulator of structural synapse plasticity and sensitized responses to cocaine and suggest that reducing MEF2 activity (and increasing spine density) in NAc may be a compensatory mechanism to limit long-lasting maladaptive behavioral responses to cocaine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The transcription factor MEF2 controls a program of gene expression that has a role in developmental synapse elimination26,29,65,66.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Self-citationJentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,130
The addicted human brain: insights from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18533 · Cited by 916
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767
Self-citationRobinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726
MEF2: a calcium-dependent regulator of cell division, differentiation and death
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02031-x · Cited by 701
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641
Self-citationHistone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599
Self-citationActivity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573
Self-citation
Cited by
Sorted by citations
Items 201–281 of 281
Datson, N. A., Speksnijder, N., de Jong, I. E. M., Steenbergen, P. J., Christensen, K. V., Potempa, K., Pedersen, J. T., Egebjerg, J., Kallunki, P., Nielsen, E. B., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2313-5 · Cited by 8
Schmitt, R. E., Shell, B. C., Lee, K. M., Shelton, K. L., Mathies, L. D., Edwards, A. C., & Grotewiel, M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14138 · Cited by 8
Brain's defence against cocaine
Chandler, L. J., & Kalivas, P. W. (2008) · Nature · doi:10.1038/455743a · Cited by 8
Bonilla-Quintana, M., & Rangamani, P. (2022) · Physical Biology · doi:10.1088/1478-3975/ac6cbe · Cited by 7
Signaling Pathways Involved in Cognitive Enhancement
Nelson, T. J., Sun, M., & Alkon, D. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417042-1.00002-4 · Cited by 7
Neural Morphology and Addiction
McGuier, N. S., Uys, J. D. K., & Mulholland, P. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00009-9 · Cited by 7
Liu, M., Tan, X., Liu, E., Hang, Z., Song, R., Mu, S., Han, W., Yue, Q., & Sun, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137305 · Cited by 6
Seo, M. H., & Yeo, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179375 · Cited by 7
West, A. E. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.016 · Cited by 7
Subsets of spiny striosomal striatal neurons revealed in the Gad1-GFP BAC transgenic mouse
Carlson, V. C. C., Mathur, B. N., Davis, M. I., & Lovinger, D. M. (2011) · Basal Ganglia · doi:10.1016/j.baga.2011.11.002 · Cited by 7
Self-citationFrom songbird to humans: The multifaceted roles of FOXP2 in speech and motor learning
Valle-Bautista, R., Olivera-Acevedo, M., Horta-Brussolo, V. R., Díaz, N. F., Ávila‐González, D., & Molina‐Hernández, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105936 · Cited by 6
Wood, D. J., Tsvetkov, E., Comte‐Walters, S., Welsh, C. L., Bloyd, M., Wood, T. G., Akiki, R. M., Anderson, E. M., Penrod, R. D., Madan, L. K., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.01.027 · Cited by 6
Self-citationCai, W. T., Yoon, H. S., Lee, S., & Kim, J. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104487 · Cited by 6
Serafini, R. A., Farzinpour, Z., Patel, V., Kelley, A. M., Estill, M. S., Pryce, K. D., Sakloth, F., Teague, C. D., Torres‐Berrío, A., Nestler, E. J., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003316 · Cited by 5
Self-citationWani, S. N., Grewal, A. K., Khan, H., & Singh, T. G. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06684-9 · Cited by 6
Putman, J. N., Watson, S. D., Zhang, Z., Khandelwal, N., Kulkarni, A., Gibson, J. R., & Huber, K. M. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0098-24.2024 · Cited by 7
Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
Turm, H., Mukherjee, D., Haritan, D., Tahor, M., & Citri, A. (2014) · Journal of Visualized Experiments · doi:10.3791/51642 · Cited by 4
Neely, M. D., Robert, E. M., Baucum, A. J., Colbran, R. J., Muly, E. C., & Deutch, A. Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.067 · Cited by 5
Rizzardi, L. F., Hickey, P. F., DiBlasi, V. R., Tryggvadóttir, R., Callahan, C. M., Idrizi, A., Hansen, K. D., & Feinberg, A. P. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/120386 · Cited by 5
Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens
Mews, P., Mason, A. V., Kirchner, E. G., Estill, M. S., & Nestler, E. J. (2025) · Communications Biology · doi:10.1038/s42003-025-08327-x · Cited by 7
Self-citationCalcium Signaling to the Nucleus
Zent, K. H., & Dell’Acqua, M. L. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_2 · Cited by 4
Regulation of Striatal Signaling by Protein Phosphatases
Girault, J., Greengard, P., & Nairn, A. C. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00029-5 · Cited by 5
Self-citationZhou, W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.97 · Cited by 4
Cocaine and Transcription Factors
González-Núñez, V., & Rodrı́guez, R. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00012-9 · Cited by 3
Mews, P., Mason, A. V., Kirchner, E. G., Estill, M. S., & Nestler, E. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.19.599762 · Cited by 4
Self-citationHistone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking
Barry, S. M., Huebschman, J. L., DeVries, D. M., McCue, L. M., Tsvetkov, E., Akiki, R. M., Limbaker, C., Anderson, E. M., Wood, D. J., Siemsen, B. M., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.027 · Cited by 4
Self-citationCarbone, M. G., Maremmani, I., Rocca, F. D., Gastaldello, G., Mazzetto, L., Bellini, A., Rizzato, R., Miccichè, R., Tripodi, B., Tagliarini, C., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15062222 · Cited by 3
Myocyte Enhancer Factor-2 (MEF2) in Diseases of Central Nervous System: A Mini Review
(2016) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2015.00001 · Cited by 3
Mediators of Glucocorticoid-Regulated Adaptive Plasticity
McEwen, B. S., & Liston, C. M. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190635374.013.3 · Cited by 3
Cai, W. T., Kim, W. Y., Kwak, M. J., Rim, H., Lee, S. E., Riecken, L. B., Morrison, H., & Kim, J. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15582 · Cited by 4
Li, J., Wu, Y. H., Xue, T., He, J., Zhang, L., Liu, Y., Zhao, J., Chen, Z., Xie, M., Xiao, B., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166569 · Cited by 4
Chakravarty, S., & Kumar, A. (2012) · Current Psychopharmacologye · doi:10.2174/2211556011201040332 · Cited by 3
Self-citationTranscriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction
Eagle, A. L., Klump, B. M., & Robison, A. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00003-8 · Cited by 4
Li, Y., Xu, H., Chitaman, J. M., & Feng, J. (2022) · Genes · doi:10.3390/genes13020306 · Cited by 2
Mitra, A., Deats, S., Dickson, P. E., Zhu, J., Gardin, J., Nieman, B. J., Henkelman, R. M., Tsai, N., Chesler, E. J., Zhang, Z., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1389-23.2024 · Cited by 2
Vishnevsky, O. V., Владимирович, Г. К., Bocharnikov, A. V., & Berezikov, E. (2011) · Springer eBooks · doi:10.1007/978-3-642-20763-1_19 · Cited by 2
Candau, J. (2009) · Elsevier eBooks · doi:10.1016/b978-2-294-70854-1.50001-5 · Cited by 2
Epigenetics of Environmental Contaminants
Onishchenko, N. R., Karpova, N. N., & Ċastrén, E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2383-6_10 · Cited by 2
Jones-Tabah, J., Martin, R., Chen, J. J., Tanny, J. C., Clarke, P. B. S., & Hébert, T. E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.01.450754 · Cited by 2
Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine
Chen, Y., Zhang, Z., Li, X., Chen, W., Huang, S., Zhang, G., Yu, Z., Zhang, L., Meng, S., Liu, J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03301-9 · Cited by 1
Orr, E., Yi, J., & Baldridge, D. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150048 · Cited by 1
Molecular Mechanisms of Drug-Induced Plasticity
Oliver, R. J., & Perrone‐Bizzozero, N. I. (2017) · InTech eBooks · doi:10.5772/67289 · Cited by 1
Epigenetic Mechanisms of Drug Addiction
Maze, I. S., & Nestler, E. J. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3_12 · Cited by 1
Self-citationArjmand, S., Ilaghi, M., Shafie’ei, M., Gobira, P. H., Grassi‐Oliveira, R., & Wegener, G. (2024) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.38 · Cited by 1
Epigenetics and alcohol use disorders
Sagarkar, S., & Sakharkar, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00018-6 · Cited by 2
Freed, W. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-10477-0_18 · Cited by 1
Harrington, A. J., Bridges, C., Blankenship, K., Assali, A., Berto, S., Siemsen, B. M., Moore, H. W., Cho, J. Y., Tsvetkov, E., Thielking, A. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/824151 · Cited by 1
Self-citationStructural plasticity of the mesolimbic system associated with female sexual reward.
Michael, N. A. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Molecular mechanisms underlying sexual reward.
Hedges, V. L. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
Hutchinson, A. N. (2011)
Kiraly, D. D., Nemirovsky, N. E., LaRese, T. P., Tomek, S. E., Olive, M. F., Eipper, B. A., & Mains, R. E. (2013)
Cocaine and Posttranslational Modifications of Neuronal Proteins
Girault, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00013-0
Macroautophagy Modulates Synaptic Function in the Striatum
Torres, C. A. (2014) · doi:10.7916/d85t3hjc
Oliver, & Robert, J. (2017) · UNM’s Digital Repository (University of New Mexico)
Abizaid, A. B., & Amir, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-27772-6_149-2
Long Noncoding RNAs in Substance Use Disorders
Tian, C., & Hu, G. (2020) · RNA technologies · doi:10.1007/978-3-030-44743-4_18
Wilkinson, L. S., & Isles, A. R. (2010) · Springer eBooks · doi:10.1007/978-3-540-68706-1_392
(2008) · Nature · doi:10.1038/455005b
Trivedi, M. S. (2013) · Digital Repository Service (Northeastern University) · doi:10.17760/d20198517
Isles, A. R., & Wilkinson, L. S. (2014) · Springer eBooks · doi:10.1007/978-3-642-27772-6_392-2
(2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2509
Isles, A. R., & Wilkinson, L. S. (2015) · Springer eBooks · doi:10.1007/978-3-642-36172-2_392
Dorit Ron, A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731384905.793538334
Methamphetamine induced regional-specific transcriptomic and epigenetic changes in the rat brainPreprint
Miao, B., Xing, X., Bazylianska, V., Madden, P. A. F., Moszczyńska, A., & Zhang, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.13.496004
Bagley, J. R., Tan, Y., Zhu, W., Cheng, Z., Takeda, S., Fang, Z., Arslan, A., Wang, M., Guan, Y., Jiang, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.21.517383
Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice
Bagley, J. R., Tan, Y., Zhu, W., Cheng, Z., Takeda, S., Fang, Z., Arslan, A., Wang, M., Guan, Y., Jiang, L., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05430-9
Roles for the MEF2 Transcription Factors in Synapse and Circuit Development and Plasticity
Zhang, Z., & Huber, K. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_11
Mukherjee, U., & Abel, T. G. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_14
Post-Translational modifications and proteomic mechanisms underlying substance use disorder.
Chakraborty, S., Dodge, A., Hochstetler, M., Jeffers, A., Jarome, T., & Mitra, S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.10.040
Kunzelman, G. W., Batistuzzo, A., & London, S. E. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23017 · Cited by 1
Liu, J., Feng, Y., Ye, Y., Ma, H., Shao, X., Yan, X., Wei, S., Yan, P., & Lai, J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110774
Elucidating the Neural Threads: Role of CREB Modulation in Nicotine Addiction Mechanisms
Chhabra, L., Khan, H., Grewal, A. K., Dua, K., Gupta, G., Singh, S. K., & Singh, T. G. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-025-00313-1
Pitchers, K. K. (2012) · Scholarship@Western (Western University)
Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice
de Oliveira, G. L., da Silva, M. C. M., Gomes, G. F., Ribeiro, R. D. S., Cussat, G. R., Fernandes, R. A., Souza, J. L. N., Fernandes, H. D. B., de Miranda, A. S., Santos, V., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1757023
Castro, F. G. (2017) · theses.fr (ABES) · doi:10.70675/b2431e98z12ecz49baz8692z44cb7b3fb5ed
Long, J.-D., Yao, S.-Y., Wu, W., Zan, G., Wang, Z.-W., Wei, X., Shu, X., Chen, Y., Ju, Y., Chen, J., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.06.001
Mesolimbic and mesocortical pathways differentially support fentanyl-context associations
Montemarano, A., Sohail, H., Murdaugh, L. B., Derr, K., Alkhaleel, F. A., Fox, L. D., Pandey, S., & Fox, M. E. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07151-3 · Cited by 1
Metadata
- Authors
- Pulipparacharuvil, S., Renthal, W., Hale, C. F., Taniguchi, M., Xiao, G., Kumar, A., Russo, S. J., Sikder, D., Dewey, C. M., Davis, M. M., Greengard, P., Nairn, A. C., Nestler, E. J., & Cowan, C. W.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Yale University (US)
- Rockefeller University (US)
- Corresponding author
- Cowan, Christopher W.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 59
- Issue
- 4
- Pages
- 621-633
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2626175
- OpenAlex
- W2047660382
- Cited by
- 281
- References
- 42
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 14 · 2023: 4 · 2022: 16 · 2021: 11 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 16 · 2016: 11 · 2015: 19 · 2014: 14 · 2013: 25 · 2012: 38
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Whitehall Foundation
- National Institute of Mental Health (P50MH074866)
- National Institute on Drug Abuse (P01DA010044, P01DA008227, R01DA007359)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- cocaine, MEF2 transcription factors, nucleus accumbens, dendritic spines, synaptic plasticity, behavioral sensitization, cAMP signaling, calmodulin signaling, calcineurin, striatum
- MeSH terms
- Adaptation, Physiological, Cyclic AMP, Animals, Behavior, Animal, Cells, Cultured, Cocaine, Drug Administration Schedule, Male, Mice, Inbred C57BL, Neuronal Plasticity, Neurons, Nucleus Accumbens, Synapses, Down-Regulation, Neostriatum, Rats, Sprague-Dawley, Myogenic Regulatory Factors, Dopamine Uptake Inhibitors, Cyclin-Dependent Kinases, Rats, Long-Evans, Gene Expression Profiling, Dendritic Spines, Mice, Rats, MEF2 Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
