Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

Sun, Binggui, Zhou, Yungui, Halabisky, Brian, Lo, Iris, Cho, Seo-Hyun, Mueller-Steiner, Sarah, Devidze, Nino, Wang, Xin, Grubb, Anders, Gan, Li·2008·Neuron
DOI 10.1016/j.neuron.2008.10.001

Cited by (231)

Items 201–231 of 231

  1. Post mortem proteolytic degradation of myosinheavy chain in skeletal muscle of Atlantic cod
    Pål Anders Wang · 2011
  2. Other Mechanisms of Neurodegeneration
    Marina Kleopatra Boziki, Vassilis Papaliagkas, Magda Tsolaki · 2011 · Wiley eBooks
  3. Identification of Novel Fluid Biomarkers for Alzheimer's Disease
    Rebecca Craig‐Schapiro · 2012 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  4. Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease
    Johan E. Sundelöf · 2010 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  5. Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
    Jacob M. Basak · 2014 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  6. Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
    Gustav Östner · 2013 · Lund University Publications (Lund University)
  7. Amyloid-/Fyn-InducedSynaptic,Network,andCognitive ImpairmentsDependonTauLevelsinMultipleMouse ModelsofAlzheimer'sDisease
    Erik D. Roberson, Jorge J. Palop · 2011
  8. Amyloid-IndependentMechanismsinAlzheimer'sDisease Pathogenesis
    RalphA . Nixon · 2010
  9. Cathepsin B: A controversial target for alzeihmer's disease
    Mohini Yadav, Ajit Avasthi · 2017 · International Journal of Pharma and Bio Sciences
  10. The Lysosome -A Central Hub for Cellular Function and Dysfunction
    Karin M. Öllinger, Hanna Appelqvist · 2017 · Journal of Cell Signaling
  11. Intracellular Trafficking and Regulation of Variant B Cystatin C in Retinal Pigment Epithelial Cells
    Riccio, A · 2017 · University of Liverpool
  12. Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
    Beate Maren Erika Koch · 2019 · eDiss (Georg-August-Universität Göttingen)
  13. Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice
    Denise Ming Tse Yu, Stephanie Dauth, Michael Bogdan Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix · 2022 · Applied Sciences
  14. Perspective Chapter: Exercise-Eating Pattern and Social Inclusion (EES) is an Effective Modulator of Pathophysiological Hallmarks of Alzheimer’s Disease
    Afroza Sultana, Md. Alauddin · 2022 · IntechOpen eBooks
  15. Identification of regulatory elements in primary sensory neurons involved in neuropathic pain
    Kimberly Stephens, Cedric D. Moore, David A. Vinson, Bryan E. White, Zachary T. Renfro, Weiqiang Zhou, Zhicheng Ji, Hongkai Ji, Heng Zhu, Yun Guan et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Calbindin-containing CA1 pyramidal cells support cognitive flexibility in spatial task in mice
    Anne Voigt, Verjinia D. Metodieva, Denis Alevi, John J. Tukker, Alexander Stumpf, Daniel Parthier, Dietmar Schmitz · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Anterior thalamic nucleus inputs to the retrosplenial cortex are unperturbed in the hAPP-J20 mouse model of Alzheimer’s disease
    Gabriella Margetts‐Smith, Lilya Andrianova, Alissa K Plant, Shivali Kohli, Cassandra Sampaio‐Baptista, Andrew D Randall, John P Aggleton, Jonathan Witton, Michael T. Craig · 2026 · Brain Communications
  18. Additional file 1 of Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
    Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Luo, Dinghao, van Dalen, Floris, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · Figshare
  19. Additional file 1 of Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer’s disease
    Li, Qiang, Li, Bing, Liu, Li, Wang, Kang-Ji, Liu, Ming-Yue, Deng, Yu, Li, Ze, Zhao, Wei-Dong, Wu, Li-Yong, Chen, Yu-Hua et al. · 2024 · Figshare
  20. Additional file 1 of Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
    Amber R. Syage, Collin Pachow, Murray, Kaitlin M., Caden M. Henningfield, Kellie Fernandez, Annie X. Du, Yuting Cheng, Gema M. Olivarria, Shimako Kawauchi, Grant R. MacGregor et al. · 2024 · Figshare
  21. Introduction of neurobiology and type 2 diabetes
    Shailendra Kumar Mishra, Kratika Tiwari, Yash Pal Singh, Hung‐Ming Chang, Jyoti John, Satyendra Chandra Tripathi, T.S. Gopenath, Brijesh Singh Chauhan, Manuela Leri, Vinod Kumar et al. · 2026 · Elsevier eBooks
  22. Mendelian Randomization Analysis of Different Cathepsin Isoforms Associated with Neurodegenerative Diseases
    Fei yang, XinYu Shi, YiNi Wang, YaPing Yin, HaoYu Wu, Kun Ma · 2026 · Current Neurovascular Research
  23. Altérations des synapses et des corps cellulaires neuronaux chez les souris APPxPS1-KI et dans la Maladie d'Alzheimer
    Alexandre Androuin · 2018 · theses.fr (ABES)
  24. Les APP-CTFs au cœur du processus pathologique de la maladie d’Alzheimer : contribution du système lysosomal-autophagique et de la sécrétion exosomale
    Anaïs Bécot · 2019 · theses.fr (ABES)
  25. Fibronectin type III domain-containing protein 5/irisin in extracellular vesicles is reduced in older individuals
    T. Hunter, Natalia M. Lyra e Silva, Guilherme B. de Freitas, Tayná Rody, Luis E Santos, Jieming Zhang, Alexis Bullock, Maria Carmela Tartaglia, Sheela A. Abraham, Chiara Nicolini et al. · 2026 · Brain Communications
  26. Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease
    Danheng Mo, Mingchun Li, Xihua Guo, Lu Zhou, Jianwen Yang, Tao Lei, Wenping Zou, Qiang Lei, Qing Wang, Chunguang Li et al. · 2026 · Frontiers in Neuroscience
  27. Small Molecules as Anti-Alzheimer’s Scaffolds
    Rudradeep Hazra, Souvik Roy, Sakuntala Gayen, Ankita Parui, Amima Arshad, Nipa Roy, Asmita Nag Sarkar · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks
  28. Mechanisms of autophagy–lysosome pathway impairment in Alzheimer's disease
    Kun Lü, Yirui Lu, Runyu Tang, Xiaofeng Dong, Pingping Zhuang, Yu Gao, Min Cheng, Yi Wang, Yubing Wang · 2026 · Journal of Alzheimer s Disease
  29. Compartment-specific inhibition of cytosolic Cathepsin B mitigates microglial senescence in the aging brain
    Simeng Zhang, Chen Zhang, Jian Mao, Junjun Ni · 2026 · Pharmacological Research
  30. Macrophage‐Derived, Rather Than Microglial, Cathepsin B Exacerbates Brain Injury After Ischemic Stroke
    Wei Kong, Hui Li, Zhou Wu, Yoshinori Hayashi, Hiroshi Nakanishi, Juan Zhao, Yutong Zhang, Hong Qing, Zhenzhen Quan, Junjun Ni · 2026 · Glia
  31. Cystatin C and its Role in the Neuro-Glial-Vascular Unit: Implications for Cerebrovascular Diseases and Neurodegeneration
    Mingchun Li, Zihao Wang, Zifeng Huang, Xihua Guo, Qing Wang, Xiaobo Wei · 2026 · Neuroscience Bulletin