A Role for Retinoic Acid in Homeostatic Plasticity
Open accessAbstract
Prolonged changes in neuronal activity trigger compensatory modifications in synaptic function to restore firing rates to normal levels. In this issue of Neuron, Aoto et al. demonstrate that synthesis of retinoic acid offsets chronic network inactivity by increasing synaptic strength through upregulation of GluR1 receptors.
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Extranuclear RARα acts as a sensor to the compensatory increased levels of RA generated upon neuronal activity for safeguarding information and homeostatic plasticity.
“Nevertheless, it highlights a novel pool of extranuclear RAR ␣ as a sensor to the compensatory increased levels of RA generated upon neuronal activity for safeguarding information and homeostatic plasticity ( 160, 161 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [161]
The Abstract reports dendritic RARα and proposes that it senses RA to increase synaptic strength, supporting the receptor’s role in homeostatic plasticity. But it explicitly calls the RA “inactivity-generated”: blocking neuronal activity increased RA synthesis. That contradicts the claim that increased RA is generated upon neuronal activity. (LLM, conf=0.86)
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Cites
Retinoid signalling in the development of the central nervous system
Maden, M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn963 · Cited by 428 · see citing works
Masiá, S., Alvarez, S., de Lera, A. R., & Barettino, D. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0062 · Cited by 184 · see citing works
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
Hou, Q., Zhang, D., Jarzylo, L., Huganir, R. L., & Man, H.-Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706447105 · Cited by 179 · see citing works
Chen, N., & Napoli, J. L. (2008) · The FASEB Journal · doi:10.1096/fj.07-8739com · Cited by 166 · see citing works
Kim, J., & Tsien, R. W. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.009 · Cited by 124 · cited 1× · see citing works
“For example, RA is a candidate retrograde messenger at hippocampal synapses where adaptation to inactivity involves clear presynaptic modifications, such as the mossy fiberCA3 synapse (Kim and Tsien, 2008).”
BackgroundSelf-citationChen, N., Onisko, B., & Napoli, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802314200 · Cited by 89 · see citing works
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Research works printed but not linked: 15
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- Burrone J O’Byrne M Murthy VN Nature 2002 420 414 418 12459783
- Chen N Napoli JL FASEB J 2008 22 236 245 17712061
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- Hou Q Zhang D Jarzylo L Huganir RL Man HY Proc. Natl. Acad. Sci. USA 2008 105 775 780 18174334 PMC2206612
- Kim J Tsien RW Neuron 2008 58 925 937 18579082 PMC2561251
- Maden M Nat. Rev. Neurosci 2002 3 843 853 12415292
- Masiá S Alvarez S de Lera AR Barettino D Mol. Endocrinol 2007 21 2391 2402 17595318
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- Shepherd JD Rumbaugh G Wu J Chowdhury S Plath N Kuhl D Huganir RL Worley PF Neuron 2006 52 475 484 17088213 PMC1764219
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Cited by
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Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408 · see citing works
- Authors
- Groth, R. D., & Tsien, R. W.
- Affiliations
- Stanford University (US)
- Corresponding author
- Groth, Rachel D.
- Tsien, Richard W.
- ORCID
- Tsien, Richard W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 60
- Issue
- 2
- Pages
- 192-194
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2712292
- OpenAlex
- W1972717738
- Cited by
- 11
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1750 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH071739)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- retinoic acid, homeostatic plasticity, GluR1, AMPA receptors, synaptic efficacy, neuronal activity, synaptic plasticity
- MeSH terms
- Action Potentials, Animals, Brain, Homeostasis, Humans, Nerve Net, Synaptic Transmission, Neuronal Plasticity, Neurons, Tretinoin, Receptors, AMPA
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