New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain
Open accessAbstract
In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.
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Astro-TE clusters 5229 and 5230 and clusters in the Astro-OLF subclass match the path of the rostral migratory stream (RMS).
“Astro-TE clusters 5229 and 5230 and clusters in the Astro-OLF subclass match the path of the rostral migratory stream70–72 (RMS; see below).”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [71]
The Introduction (page unavailable) describes the RMS as the route from the subventricular zone to the olfactory bulb, and the Results describe astrocytes along that pathway. The paper does not identify Astro-TE clusters 5229 or 5230, Astro-OLF clusters, or show that those clusters match the RMS path. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAstro-TE clusters 5229 and 5230, located in the lateral ventricle bordering rostral dorsal STR, and clusters belonging to the Astro-OLF subclass (5231-5236) match the path of the RMS; the trajectory of these astrocyte clusters on the UMAP matches well with the corresponding spatial gradients.
“Astro-TE clusters 5229 and 5230, located in the lateral ventricle bordering rostral dorsal STR, and clusters belonging to the Astro-OLF subclass (5231–5236) match the path of the RMS70–72 (Extended Data Fig. 12h); the trajectory of these astrocyte clusters on the UMAP matches well with the corresponding spatial gradients”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [71]
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Experimental — accuracy not yet measuredThe migrating neurons in the RMS are separated from the parenchyma by astrocytes that form tunnels through which the cells migrate.
“The migrating neurons in the RMS are separated from the parenchyma by astrocytes that form tunnels through which the cells migrate71,86.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [71]
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References 47 · Cited by 212
- Authors
- Kaneko, N., Marín, O., Koike, M., Hirota, Y., Uchiyama, Y., Wu, J. Y., Lu, Q., Tessier-Lavigne, M., Alvarez-Buylla, A., Okano, H., Rubenstein, J. L. R., & Sawamoto, K.
- Affiliations
- Nagoya City University (JP)
- Juntendo University (JP)
- Northwestern University (US)
- Keio University (JP)
- University of California, San Francisco (US)
- Corresponding author
- Sawamoto, Kazunobu
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 2
- Pages
- 213-223
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4080818
- OpenAlex
- W2064759994
- Cited by
- 212
- References
- 47
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 21 · 2019: 8 · 2018: 13 · 2017: 20 · 2016: 19 · 2015: 15 · 2014: 10 · 2013: 17 · 2012: 21
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- James S. McDonnell Foundation
- Novartis Foundation
- Inoue Foundation for Science
- Kowa Company
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Kowa Life Science Foundation
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Toray Science Foundation
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Cancer Institute (CA107193, CA114197, R01CA107193, R01CA114197)
- National Institute of Neurological Disorders and Stroke (R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- adult neurogenesis, neuronal migration, astrocytes, Slit1, Robo receptors, subventricular zone, olfactory bulb, neuron-glia interactions, directional migration
- MeSH terms
- Doublecortin Domain Proteins, Roundabout Proteins, Amino Acids, Animals, Animals, Newborn, Astrocytes, Brain, Bromodeoxyuridine, Cell Count, Cell Movement, Cells, Cultured, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Luminescent Proteins, Mice, Transgenic, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Organ Culture Techniques, Organic Chemicals, Receptors, Immunologic, Transfection, Brain Tissue Transplantation, Statistics, Nonparametric, Coculture Techniques, Lateral Ventricles, Microscopy, Electron, Transmission, Green Fluorescent Proteins, Mice
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