A neural switch for active and passive fear

Gozzi, Alessandro, Jain, Apar, Giovanelli, Aldo, Bertollini, Cristina, Crestan, Valerio, Schwarz, Adam J., Tsetsenis, Theodoros, Ragozzino, Davide +2 more·2010·Neuron
DOI 10.1016/j.neuron.2010.07.008

Cited by (208)

Items 101–200 of 208

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  3. Topographic representation of current and future threats in the mouse nociceptive amygdala
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  4. Prefrontal infralimbic cortex mediates competition between excitation and inhibition of body movements during pavlovian fear conditioning
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  7. Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala
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  11. Inactivation of neuronal function in the amygdaloid region reduces tail artery blood flow alerting responses in conscious rats.
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  12. The Relationship between Amygdala Activation and Passive Exposure Time to an Aversive Cue during a Continuous Performance Task
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  13. The Contribution of the Amygdala to Aversive and Appetitive Pavlovian Processes
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  14. Hyperbaric oxygen therapy restored traumatic stress-induced dysregulation of fear memory and related neurochemical abnormalities
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  15. Diverse Effects of Conditioned Threat Stimuli on Behavior
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  16. Early life adversity ablates sex differences in active versus passive threat responding in mice
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  18. Neuronal circuits of fear memory and fear extinction
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  19. Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala
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  28. The dynamic consequences of amygdala damage on threat processing in Urbach-Wiethe Disease. A commentary on Pishnamazi et al. (2016).
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  41. Behavior of Rats with High and Low Levels of Freezing in Defensive Situations and on Selection of Food Reinforcement
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  45. Oxytocin Attenuates Yohimbine-Induced Reinstatement of Alcohol-Seeking in Female Rats via the Central Amygdala
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  46. Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation
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  47. Fear Models in Animals and Humans
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  51. Consolidation of altered associability information by amygdala central nucleus
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  56. Nodal Structures in Anxiety-Like and Panic-Like Responses
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  57. Protect and harm: Effects of stress on the amygdala
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  59. δ and θ Modulation of Fast γ Activity in the Ventral Tegmental Area of the Midbrain in Rats During a Conditioned Avoidance Reflex
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  60. Cognitive Factors Affecting Freeze-like Behavior in Humans
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  64. Speed dependent descending control of innate freezing behavior in Drosophila melanogaster
    Ricardo Zacarias, Shigehiro Namiki, Gwyneth M Card, Maria Luísa Vasconcelos, Marta A. P. Moita · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  65. Covert muscle activity reveals dynamic freezing states and prepares the animal for action
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  66. Disruption of Long-Term Depression Potentiates Latent Inhibition: Key Role for Central Nucleus of the Amygdala
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  67. Epilepsy, compulsion and oxytocin: Insights from behavioral sequences, using neuroethology and complexity systems approaches.
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  70. General Conclusions
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  71. Cannabinoid Control of Fear Responses
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  72. Neuronal Correlates of Remote Fear Learning in Rats
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  73. Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders
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  76. Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors
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  80. Optogenetic Stimulation of Dopamine Afferents in Nucleus Accumbens and Central Amygdala Reveals Differential Roles in Food and Social Motivation
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  82. Role of D1 receptor antagonism in contextual fear learning and memory
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  91. Introduction
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  92. INHIBITION TRAINING AS ONE OF BASIC FACTORS OF THE COMING INTO BEING OF THE PERSON
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  93. References
    2015 · Elsevier eBooks
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    Tina M. Gruene · 2017
  95. Faculty Opinions recommendation of Dorsal tegmental dopamine neurons gate associative learning of fear.
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