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Cited by 171Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNerve injury and regeneration

Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis

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Jakawich, Sonya K., Nasser, Hassan B., Strong, Michael J., McCartney, Amber J., Perez, Amanda S., Rakesh, Neal, Carruthers, Cynthia J.L., Sutton, Michael A.·2010·Neuron
DOI 10.1016/j.neuron.2010.11.034PMC PMC3046391
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Abstract

Homeostatic synaptic plasticity is important for maintaining stability of neuronal function, but heterogeneous expression mechanisms suggest that distinct facets of neuronal activity may shape the manner in which compensatory synaptic changes are implemented. Here, we demonstrate that local presynaptic activity gates a retrograde form of homeostatic plasticity induced by blockade of AMPA receptors (AMPARs) in cultured hippocampal neurons. We show that AMPAR blockade produces rapid (<3 hr) protein synthesis-dependent increases in both presynaptic and postsynaptic function and that the induction of presynaptic, but not postsynaptic, changes requires coincident local activity in presynaptic terminals. This "state-dependent" modulation of presynaptic function requires postsynaptic release of brain-derived neurotrophic factor (BDNF) as a retrograde messenger, which is locally synthesized in dendrites in response to AMPAR blockade. Taken together, our results reveal a local crosstalk between active presynaptic terminals and postsynaptic signaling that dictates the manner by which homeostatic plasticity is implemented at synapses.

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  • Postsynaptic BDNF release has been implicated in the rapid local regulation of Pr.

    “Interestingly, postsynaptic BDNF release has recently been implicated in the rapid local regulation of P r (Jakawich et al. 2010), and BDNF is clearly important for the development and regulation of inhibitory synaptic transmission (Huang et al. 1999).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Jakawich et al. 2010

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References 48 · Cited by 171

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Authors
Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A.
Affiliations
University of Michigan (US)
Corresponding author
Sutton, Michael A.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2010-12
Volume
68
Issue
6
Pages
1143-1158
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2010.11.034
PMC
PMC3046391
OpenAlex
W2074581529
Cited by
171
References
48
Citations by year
2026: 2 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 25 · 2012: 20
FWCI
7.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH085798)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
homeostatic plasticity, presynaptic terminals, retrograde signaling, AMPA receptor blockade, hippocampal neurons, presynaptic function
MeSH terms
Animals, Animals, Newborn, Cells, Cultured, Dendrites, Hippocampus, Homeostasis, Ion Channel Gating, Presynaptic Terminals, Receptors, AMPA, Brain-Derived Neurotrophic Factor, Rats

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