RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

Deng, Lunbin, Kaeser, Pascal S., Xu, Wei, Südhof, Thomas C.·2011·Neuron

Cited by (288)

Items 201–288 of 288

  1. Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors
    José Javier Ferrero, Magdalena Torres, José Sánchez‐Prieto · 2011 · Neuroscience Letters
  2. Exogenous nanomolar zinc ion (Zn2+) as a negative modulator of neuromuscular transmission via presynaptic mechanism in mouse diaphragm
    Arthur N. Khaziev, Andrei N. Tsentsevitsky, Nikita S. Fedorov, Eva A. Kuznetsova, Artem I. Malomouzh, Elena O. Petukhova, Vadim V. Salnikov, Irina V. Kovyazina, Alexey M. Petrov · 2025 · BioMetals
  3. Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy
    Mehri Moradi, Julia Weingart, Chunchu Deng, Mahoor Nasouti, Michael Briese, Sibylle Jablonka, Markus Sauer, Michael Sendtner · 2025 · Nature Communications
  4. Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release
    Hong Zhang, Mengshi Lei, Yu Zhang, Hao Li, Zhen He, Sheng Xie, Le Zhu, Shen Wang, Jianfeng Liu, Yan Li et al. · 2024 · Science Advances
  5. Differential Requirement for Protein Synthesis in Presynaptic Unmuting and Muting in Hippocampal Glutamate Terminals
    Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, Krista L. Moulder, Steven J. Mennerick · 2012 · PLoS ONE
  6. Nanocolumns at the heart of the synapse
    Stephan J. Sigrist, Astrid G. Petzoldt · 2016 · Nature
  7. Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging
    Achmed Mrestani, Sven Dannhäuser, Martin Pauli, Philip Kollmannsberger, Martha Hübsch, Lydia Morris, Tobias Langenhan, Manfred Heckmann, Mila Marie Paul · 2023 · Life Science Alliance
  8. RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans
    Wan-Juan FENG, Tao Liang, JunWei Yu, Wei Zhou, Yongdeng Zhang, Zheng‐Xing Wu, Tao Xu · 2012 · Science China Life Sciences
  9. C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release
    Mia Krout, Kelly Hyunju Oh, Ame Xiong, Elisa B. Frankel, Peri T. Kurshan, Hongkyun Kim, Janet E. Richmond · 2023 · Proceedings of the National Academy of Sciences
  10. Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice
    Yuting Yuan, Yang Li, Fuqiang Yang, Yisheng Jiang, Yuanyuan Ding, Ying Xiao, Xili Zhu, Xingmei Shu, Xiahe Huang, Yingchun Wang et al. · 2025 · Molecular Psychiatry
  11. Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry
    Yizhi Li, Elinor H. Case, Christopher Blanchard, Anna Monteleone, Meera Gandhi, Anousha Jaie, Yomna Badawi, Stephen D. Meriney · 2025 · The Journal of Physiology
  12. Milligram Quantities of Homogeneous Recombinant Full-Length Mouse Munc18c from Escherichia coli Cultures
    Asma Rehman, Russell J. Jarrott, Andrew E. Whitten, Gordon J. King, Shuhong Hu, Michelle P. Christie, Brett M. Collins, Jennifer L. Martin · 2013 · PLoS ONE
  13. Probing the Diacylglycerol Binding Site of Presynaptic Munc13-1
    Youngki You, Sachin S. Katti, Binhan Yu, Tatyana I. Igumenova, Joydip Das · 2021 · Biochemistry
  14. Molecular definition of distinct active zone protein machineries for Ca 2+ channel clustering and synaptic vesicle priming
    Javier Emperador-Melero, Jonathan W. Andersen, Sarah R. Metzbower, Aaron D. Levy, Poorna A. Dharmasri, Giovanni de Nola, Thomas A. Blanpied, Pascal S. Kaeser · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones
    Joydip Das, Youngki You, Kavya Mathukumalli, Jihyae Ann, Jeewoo Lee, Víctor E. Márquez · 2023 · Biochemistry
  16. RIM and MUNC13 membrane–binding domains are essential for neuropeptide secretion
    Murphy, Fiona H., Abramian, Adlin, Klaassen, Remco V., Koopmans, Frank, Persoon, Claudia M., Smit, August B., Toonen, Ruud F., Verhage, Matthijs · 2025 · Journal of Cell Biology
  17. Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
    Reza Asadollahi, Aisha Ahmad, Paranchai Boonsawat, Jasmine Shahanoor Hinzen, Mareike Lohse, Boris Bouazza‐Arostegui, Siqi Sun, Tillmann Utesch, Jonas D. Sommer, Dragana Ilic et al. · 2025 · Nature Genetics
  18. Distinctive characteristics of dopamine neuron release mechanisms: Insights into Parkinson’s Disease
    Emanuele Di Martino, Sarinah Maduro, Antonio Luchicchi, Micha M.M. Wilhelmus, Nicola Salvatore Orefice · 2026 · Biomedicine & Pharmacotherapy
  19. Presynaptic Cytomatrix Proteins
    Yishi Jin, Rong Grace Zhai · 2023 · Advances in neurobiology
  20. Adaptive and non‐adaptive changes in activity‐deprived presynaptic terminals
    Süzel Horellou, Olivier Pascual, Antoine Triller, Serge Marty · 2013 · European Journal of Neuroscience
  21. Functional Roles of UNC-13/Munc13 and UNC-18/Munc18 in Neurotransmission
    Frédéric A. Meunier, Zhitao Hu · 2023 · Advances in neurobiology
  22. Der molekulare Mechanismus der Neurotransmitterfreisetzung und Nervenzell-Synapsen (Nobel-Aufsatz)†
    T. Südhof · 2014 · Angewandte Chemie
  23. Investigation of Vesicle Pool Dynamics at Activity Modulated Inner Hair Cell Ribbon Synapses
    Rituparna Chakrabarti · 2018
  24. Molecular and Morphological Correlates of Synaptic Vesicle Priming
    Cordelia Imig · 2014
  25. Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13
    Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Xiao-Chun Yu, Jing Tang, Huisheng Liu, Xiaofei Yang, Cong Ma et al. · 2025 · eLife
  26. The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
    Charlotte M. Fischer, Zenon Toprakcioglu, Ella de Csilléry, Gabriele S. Kaminski Schierle, Tuomas P. J. Knowles · 2025 · ACS Nano
  27. Recent Structural Insights into the Molecular Architecture of Synapses
    Axel T. Brünger, Richard G. Held, Yousuf A. Khan, Jeremy Leitz, Jiahao Liang, Chuchu Wang, K. Ian White · 2026 · Advances in neurobiology
  28. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis
    Kexu Zhao, Li Zhang, Mengshi Lei, Ziqi Jin, Ting Du, Hong Zhang, Yin Sheng, Zhitao Hu, Shen Wang, Cong Ma · 2025 · Proceedings of the National Academy of Sciences
  29. La machinerie moléculaire de sécrétion des neurotransmetteurs
    T. Südhof · 2015 · Biologie Aujourd hui
  30. Studying synaptic efficiency by post-hoc immunolabelling
    Jorge Ramírez‐Franco, Beatris Alonso, David Bartolomé‐Martín, José Sánchez‐Prieto, Magdalena Torres · 2013 · BMC Neuroscience
  31. Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases
    Sumiko Mochida · 2014 · Springer eBooks
  32. Reciprocal Regulation of Neuronal Calcium Channels by Synaptic Proteins
    Norbert Weiss, Gerald Werner Zamponi · 2013 · Springer eBooks
  33. Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves
    Judyta Karolina Juranek, Konark Mukherjee, Reinhard Jahn, Jiayi Li · 2021 · Biochemical and Biophysical Research Communications
  34. A Single Vesicle Assay to Study the Electrochemical Gradient Regulation in Glutamatergic and GABAergic Synaptic Vesicles
    Zohreh Farsi · 2016
  35. Characterization of the Functional Domains of a Novel Vertebrate-Specific Presynaptic Protein-Mover
    Asha Kiran Akula · 2016
  36. Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates
    Hong Zhang, Yu Zhang, Zhifei Zhao, Zelin Cao, Kexu Zhao, Mengshi Lei, Shen Wang, Cong Ma · 2026 · Proceedings of the National Academy of Sciences
  37. Approche génétique des mécanismes d’exocytose pendant le développement des circuits neuronaux
    Patrícia Gaspar, Xavier Nicol, Nicolas Narboux‐Nême, Alexandra Rebsam · 2015 · Biologie Aujourd hui
  38. 线虫中RAB-27 与其效应物RBF-1 调控致密核心囊泡的栓系和锚定过程
    滔 梁, 俊伟 于, 婉娟 冯, 永登 章, 涛 徐, 政星 吴, 围 周 · 2012 · Scientia Sinica Vitae
  39. Network of Protein-Protein Interactions at the Presynaptic Active Zone
    Toshihisa Ohtsuka · 2014 · Springer eBooks
  40. Investigation Of The Molecular Mechanisms Of Synaptic Tagging And Capture
    Jung Whan Park · 2014 · Scholarly Commons (University of Pennsylvania)
  41. Electrophysiological Analysis of the Synaptic Vesicle Priming Process
    Dennis Nestvogel · 2017
  42. Molecular profiling of presynaptic docking sites
    Anne Janina Boyken · 2011
  43. The Cell at Molecular Resolution
    Rubén Fernández‐Busnadiego, Vladan Lučić · 2012 · Elsevier eBooks
  44. Molecular mechanisms of biphasic insulin secretion
    Nikhil R. Gandasi · 2015 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  45. Molecular mechanisms of short-term plasticity as a basis of frequency coding: The role of proteolytic systems
    Irina V. Kudryashova · 2014 · Neurochemical Journal
  46. Spotlight on the active zone
    Nava Segev, Simon T. Alford · 2011 · Cellular Logistics
  47. Structural and functional maturation of presynaptic nerve endings under the control of transsynaptic signalling
    Nina Wittenmayer, T. Dresbach · 2012 · e-Neuroforum
  48. Genetic dissections of active zone proteins
    Karen Suk Yin Liu · 2012 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  49. Architecture of the photoreceptor ribbon synapse: L-type voltage-gated calcium channel mobility and the role of cholesterol in neurotransmission
    Aaron J. Mercer · 2011 · DigitalCommons@UNMC
  50. Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
    Kwun Nok Mimi Man · 2015
  51. CAUSES AND CONSEQUENCES OF REDUCED EXPRESSION OF SNAP-25 IN NEURONAL NETWORKS
    S. De Astis · 2012 · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)
  52. Exploring Synaptic Vesicle Exocytosis
    Pablo Ariel · 2025 · Digital Commons - RU (Rockefeller University)
  53. UNC-10 Regulates The Docking Step of DCV Exocytosis in C. elegans*
    Wan-Juan FENG, Wei Zhou, Yongdeng Zhang, Zheng‐Xing Wu, Tao Xu · 2012 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
  54. Biochemical characterization of presynaptic membrane protein complexes
    Momchil Ninov · 2017
  55. In Vivo Recordings at the Caenorhabditis elegans Neuromuscular Junction
    Shangbang Gao, Zhitao Hu · 2017 · Neuromethods
  56. Molecular physiology of signal transmission along the auditory pathway
    Tanvi Butola · 2017
  57. Charakterisierung des Targetingverhaltens präsynaptischer Proteine
    Donatus Riemann · 2018
  58. Study of a kinesin adaptor in axonal transport and synapse formation
    Tahere Kalantary Dehaghi · 2019
  59. Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion
    Victor A. Cazares, Edward L. Stuenkel · 2020 · Masterclass in neuroendocrinology
  60. Control of neurotransmitter release and presynaptic plasticity by re-orientation of membrane-bound Munc13-1
    Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Reconstructing essential active zone functions within a synapse
    Chao Tan, Shan Shan H. Wang, Giovanni de Nola, Pascal S. Kaeser · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Faculty Opinions recommendation of Munc13 controls the location and efficiency of dense-core vesicle release in neurons.
    Jens Rettig, David R. Stevens · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  63. Characterization of Synaptic Transmission Abnormalities in Neurological Disorders of the Presynaptic Terminal
    Ahmad, Aisha Munawar · 2022
  64. Global Analysis of Protein Phosphorylation Regulation upon Stimulation of Exocytosis in the Nerve Terminal
    Mahdokht Kohansal-Nodehi · 2017
  65. The activation of mGluR4 rescues parallel fiber LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
    Ricardo Martín, Alberto Samuel Suárez-Pinilla, Nuria García-Font, M. Luisa Laguna-Luque, Juan Carlos López, María Jesús Oset‐Gasque, Agnès Gruart, Jose Maria Delgado-Garcia, Magdalena Torres, José Sánchez‐Prieto · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Munc13 and Associated Molecules☆
    Robby M. Weimer, J. Richmond · 2015 · Elsevier eBooks
  67. In brief
    2011 · Nature reviews. Neuroscience
  68. Active Zone☆
    M.Y. Wong, Pascal S. Kaeser · 2014 · Elsevier eBooks
  69. Rab3 Interacting Molecules (RIMs)☆
    Arthur P.H. de Jong, Pascal S. Kaeser · 2015 · Elsevier eBooks
  70. Release site plasticity via Unc13A regulatory domains mediates synaptic short-term facilitation and homeostatic potentiation
    Meida Jusyte, Natalie Blaum, Mathias A. Böhme, Manon M. M. Berns, Alix E. Bonard, Janus RL Kobbersmed, Alexander M. Walter · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Revealing ultrastructural changes that determine the development of a CNS synapse
    Anika Hintze · 2023
  72. Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
    Theocharis Alvanos · 2023
  73. Impact+of+Sleep+Deprivation+on+Alcohol+Behaviors+in+Presynaptic+Neurons+of+Drosophila+melanogaster
    Alissa Kalyan · 2024
  74. Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
    Sofia Ainatzi · 2024
  75. Synaptic Function
    Dimitri Michael Kullmann, Kirill E. Volynski · 2025 · Oxford University Press eBooks
  76. Mechanism that regulates the mutual inhibition controls functional switch of UNC-13
    Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Cong Ma, Lijun Kang, Zhitao Hu · 2025 · eLife
  77. Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13
    Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Xiao-Chun Yu, Jing Tang, Huisheng Liu, Xiaofei Yang, Cong Ma et al. · 2025 · eLife
  78. Mechanisms that regulate the C1-C2B mutual inhibition control the functional switch of UNC-13
    Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Xiao-Chun Yu, Huisheng Liu, Xiaofei Yang, Cong Ma, Lijun Kang et al. · 2025 · eLife
  79. Overview: Spatial and Temporal Regulation of Ca2+ Channels
    Sumiko Mochida · 2013 · Springer eBooks
  80. Active Zone Assembly
    Thomas Dresbach · 2014 · Springer eBooks
  81. Optical Approaches to Dissect the Structure and Dynamics of the Synapse at Nanoscale Resolution
    Jongyun Myeong, Vitaly A. Klyachko · 2026 · Advances in neurobiology
  82. Role of the actomyosin cytoskeleton on the synaptic effects of the type-1 cannabinoid receptor (CB1R)
    Maureen H McFadden · 2018 · theses.fr (ABES)
  83. Computational approach to the study of neurotransmitter release
    Maria Reva · 2018
  84. Pathophysiological consequences of a Fragile X missense mutation
    Marta Prieto Garcia · 2020 · theses.fr (ABES)
  85. Membranes remodeling by proteins in intracellular trafficking : a bottom up approach of the roles of golgins for Golgi structuration and of SNAREs for synaptic fusion
    Delphine Mion · 2025
  86. Dissecting the propensity of RIM1 subdomains to form phase condensates
    Luis Kersten, Maksim Galkov, Paulina Nemcova, Aya Hanaey Dandrawy Mostafa, Anne Quatraccioni, Dirk Dietrich, Susanne Schoch · 2026 · Scientific Reports
  87. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release
    Joseph J. Lebowitz, Aditi Banerjee, Gillian E. Handy, John T. Williams, Pascal S. Kaeser · 2026 · Journal of Neuroscience
  88. Engineered proteins to restore and enhance neurotransmitter release
    Morven Chin, Ke Yang, Ricardo López C., Chao Tan, Pascal S. Kaeser · 2026 · bioRxiv (Cold Spring Harbor Laboratory)