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Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling
Open accessAbstract
Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2 promotes the migration of nascent cortical neurons by inducing the expression of the atypical Rho GTPase Rnd2. Here, we show that another proneural factor, Ascl1, promotes neuronal migration in the cortex through direct regulation of a second Rnd family member, Rnd3. Both Rnd2 and Rnd3 promote neuronal migration by inhibiting RhoA signaling, but they control distinct steps of the migratory process, multipolar to bipolar transition in the intermediate zone and locomotion in the cortical plate, respectively. Interestingly, these divergent functions directly result from the distinct subcellular distributions of the two Rnd proteins. Because Rnd proteins also regulate progenitor divisions and neurite outgrowth, we propose that proneural factors, through spatiotemporal regulation of Rnd proteins, integrate the process of neuronal migration with other events in the neurogenic program.
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Cites
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246 · cited 2×
“…by preventing their premature differentiation through transcriptional repression of several regulators of the neuronal cytoskeleton, including microtubule-associated protein 2 (MAP2), growth-associated protein 43 (GAP43), and p-21-activated serine/threonine kinase 3 (PAK3) (Cobos et al., 2007).”
Neurons in motion: same principles for different shapes?
Marín, O., Valdeolmillos, M., & Moya, F. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.001 · Cited by 71
Cited by
Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.081 · Cited by 503
bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells
Imayoshi, I., & Kageyama, R. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.018 · Cited by 278
Klaus, J., Kanton, S., Kyrousi, C., Ayo-Martin, A. C., Di Giaimo, R., Riesenberg, S., O’Neill, A. C., Camp, J. G., Tocco, C., Santel, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0371-0 · Cited by 169
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani, H., Martin, E., Hassani, H., Clavairoly, A., Maire, C. L., Viadieu, A., Kerninon, C., Delmasure, A., Frah, M., Weber, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-13.2013 · Cited by 158
Self-citationCdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
Tang, J., Ip, J. P. K., Ye, T., Ng, Y.-P., Yung, W.-H., Wu, Z., Fang, W., Fu, A. K. Y., & Ip, N. Y. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5449-13.2014 · Cited by 68
Metadata
- Authors
- Pacary, E., Heng, J., Azzarelli, R., Riou, P., Castro, D., Lebel-Potter, M., Parras, C., Bell, D. M., Ridley, A. J., Parsons, M., & Guillemot, F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 69
- Issue
- 6
- Pages
- 1069-1084
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2111444437
- Cited by
- 216
- References
- 2
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pacary, E., Heng, J., Azzarelli, R., Riou, P., Castro, D., Lebel-Potter, M., Parras, C., Bell, D. M., Ridley, A. J., Parsons, M., & Guillemot, F. (2011). Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling. Neuron. https://doi.org/10.1016/j.neuron.2011.02.018
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