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Cited by 205Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

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Miwa, Julie M., Freedman, Robert, Lester, Henry A.·2011·Neuron
DOI 10.1016/j.neuron.2011.03.014PMC PMC4418790
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Abstract

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate in diverse functions: reward, learning and memory, mood, sensory processing, pain, and neuroprotection. Nicotinic systems also have well-known roles in drug abuse. Here, we review recent insights into nicotinic function, linking exogenous and endogenous manipulations of nAChRs to alterations in synapses, circuits, and behavior. We also discuss how these contemporary advances can motivate attempts to exploit nicotinic systems therapeutically in Parkinson's disease, cognitive decline, epilepsy, and schizophrenia.

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Authors
Miwa, J. M., Freedman, R., & Lester, H. A.
Affiliations
  • California Institute of Technology (US)
  • University of Colorado Denver (US)
Corresponding author
Lester, Henry A.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2011-04
Volume
70
Issue
1
Pages
20-33
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2011.03.014
PMC
PMC4418790
OpenAlex
W2070740144
Cited by
205
References
158
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 12 · 2018: 5 · 2017: 12 · 2016: 17 · 2015: 22 · 2014: 28 · 2013: 30 · 2012: 30
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
  • National Institute on Aging (R01AG033954, AG-33954)
  • National Institute of Mental Health (MH-86386, R01MH086386)
  • National Institute on Drug Abuse (DA-11729)
  • National Institute of Neurological Disorders and Stroke (NS 11756, R01NS011756)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
nicotinic acetylcholine receptors, cholinergic neurons, neural circuits, drug abuse, reward, learning and memory, mood, pain, neuroprotection, Parkinson's disease, cognitive decline, epilepsy, schizophrenia, therapeutic targeting
MeSH terms
Animals, Cholinergic Fibers, Humans, Nervous System Diseases, Neural Pathways, Neurons, Receptors, Nicotinic

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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