Role of Astrocytes in Neurovascular Coupling
Open accessAbstract
Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in space and time that modern imaging methods use local hemodynamics as a measure of brain activity. In this review, we discuss recent evidence indicating that neuronal activity is coupled to local blood flow changes through an intermediary, the astrocyte. We highlight unresolved issues regarding the role of astrocytes and propose ways to address them using novel techniques. Our focus is on cellular level analysis in vivo, but we also relate mechanistic insights gained from ex vivo experiments to native tissue. We also review some strategies to harness advances in optical and genetic methods to study neurovascular coupling in the intact brain.
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Aging impairs cerebromicrovascular endothelial vasodilation and endothelium-mediated neurovascular coupling responses.
“and impairs cerebromicrovascular endothelial vasodilation and endothelium-mediated neurovascular coupling responses (Petzold and Murthy 2011; Stobart et al. 2013; Wells et al. 2015; Chen et al. 2014)”
From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Petzold and Murthy 2011
The cascade of metabolic and vascular events known as neurovascular coupling involves complex signaling among neurons, astrocytes, and the local vasculature and remains a topic of active research.
“Such a cascade of metabolic and vascular events, known as the neurovascular coupling, involves complex signaling among neurons, astrocytes, and the local vasculature (124, 126, 127), and remains a topic of active research enabled by emerging tools (128).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [126]
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References 196 · Cited by 409
- Authors
- Petzold, G. C., & Murthy, V. N.
- Affiliations
- University Hospital Bonn (DE)
- Harvard University (US)
- Corresponding author
- Petzold, Gabor C.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 71
- Issue
- 5
- Pages
- 782-797
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1980610697
- Cited by
- 409
- References
- 196
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 9 · 2023: 22 · 2022: 29 · 2021: 27 · 2020: 39 · 2019: 19 · 2018: 37 · 2017: 29 · 2016: 34 · 2015: 37 · 2014: 38 · 2013: 32 · 2012: 24
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- astrocytes, neurovascular coupling, cerebral blood flow, neuronal activity, hemodynamics, astrocyte-neuron interaction, in vivo imaging
- MeSH terms
- Animals, Astrocytes, Blood Vessels, Brain, Cerebrovascular Circulation, Humans, Models, Biological, Neurons, Synapses
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