Multisensory Integration of Natural Odors and Sounds in the Auditory Cortex
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Video abstract Motherhood is associated with different forms of physiological alterations including transient hormonal changes and brain plasticity. The underlying impact of these changes on the emergence of maternal behaviors and sensory processing within the mother's brain are largely unknown. By using in vivo cell-attached recordings in the primary auditory cortex of female mice, we discovered that exposure to pups' body odor reshapes neuronal responses to pure tones and natural auditory stimuli. This olfactory-auditory interaction appeared naturally in lactating mothers shortly after parturition and was long lasting. Naive virgins that had experience with the pups also showed an appearance of olfactory-auditory integration in A1, suggesting that multisensory integration may be experience dependent. Neurons from lactating mothers were more sensitive to sounds as compared to those from experienced mice, independent of the odor effects. These uni- and multisensory cortical changes may facilitate the detection and discrimination of pup distress calls and strengthen the bond between mothers and their neonates.
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Pup calls evoke more robust cortical responses in experienced maternal mice compared to inexperienced or naïve virgins.
“Pup calls evoke more robust cortical responses in experienced maternal mice compared to inexperienced or naïve virgins”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Cohen et al. 2011
Single-cell recordings in the primary auditory cortex of female mice revealed that exposure to a pup's body odour can reshape neuronal response to pure tones and natural auditory stimuli.
“single-cell recordings in the primary auditory cortex of female mice revealed that exposure to a pup's body odour can reshape neuronal response to pure tones and natural auditory stimuli [162].”
From The Role of Intrinsic and Extrinsic Sensory Factors in Sweetness Perception of Food and Beverages: A Review (2019) · cites this paper as [162]
Neural representations of pup vocalizations in the auditory cortex undergo experience-dependent plasticity with the transition to motherhood, thus enhancing auditory responses to pup calls.
“Neural representations of pup vocalizations in the auditory cortex also undergo experience-dependent plasticity with the transition to motherhood (Fig. 1B-D), thus enhancing auditory responses to pup calls”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Cohen et al., 2011
Pup distress calls are overrepresented in dams compared to virgins, leading to a stronger activation of the deep layers and increased noise correlation in layer II/III of auditory cortex in lactating females.
“Pup distress calls are overrepresented in dams compared to virgins, leading to a stronger activation of the deep layers and increased noise correlation in layer II/III of auditory cortex in lactating females”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Cohen et al., 2011
Long-lasting plasticity in somatosensory and auditory cortex contributes to increased responsiveness to infant cues.
“long-lasting plasticity in somatosensory (Rosselet et al., 2006; Xerri et al., 1994) and auditory (Cohen et al., 2011; Cohen and Mizrahi, 2015; Liu et al., 2006; Liu and Schreiner, 2007; Marlin et al., 2015; Shepard et al., 2016; Tasaka et al., 2018) cortex have recently been shown to contribute to increased responsiveness to infant cues”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Cohen et al., 2011
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References 70 · Cited by 192
- Authors
- Cohen, L., Rothschild, G., & Mizrahi, A.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Mizrahi, Adi
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 72
- Issue
- 2
- Pages
- 357-369
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2085900799
- Cited by
- 192
- References
- 70
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 9 · 2023: 17 · 2022: 15 · 2021: 8 · 2020: 19 · 2019: 17 · 2018: 15 · 2017: 10 · 2016: 8 · 2015: 13 · 2014: 10 · 2013: 21 · 2012: 6
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- multisensory integration, primary auditory cortex, maternal behavior, lactation, experience-dependent plasticity, auditory sensitivity, female mice
- MeSH terms
- Acoustic Stimulation, Animals, Animals, Newborn, Auditory Cortex, Auditory Perception, Female, Lactation, Maternal Behavior, Nerve Net, Neurons, Odorants, Sensation, Mice, Olfactory Perception
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