Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

Osterweil, Emily K., Chuang, Shih-Chieh, Chubykin, Alexander A., Sidorov, Michael, Bianchi, Riccardo, Wong, Robert K.S., Bear, Mark F.·2013·Neuron
DOI 10.1016/j.neuron.2012.01.034

Cited by (230)

Items 201–230 of 230

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  2. Lovastatin as fragile X therapy
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  3. What Mechanisms Induce Methylation of FMR1 Gene Full Mutation? A Still Unanswered Question
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  4. FMRP and the Pathophysiology of Fragile X Syndrome
    Stephanie A. Barnes, Sophie R. Thomson, Peter C. Kind, Emily K. Osterweil · 2016 · Elsevier eBooks
  5. Profilin isoforms in the hippocampus in health and disease
    Sabine Zessin · 2014 · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG))
  6. Identifying barriers to clinical trial participation with families affected by fragile X syndrome
    Sarah E. A. Eley · 2017 · Edinburgh Research Archive (University of Edinburgh)
  7. Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
    Vashi, Neeti · 2021 · TSpace (University of Toronto)
  8. Excess ribosomal protein production unbalances translation in Fragile X Syndrome
    Sang S. Seo, Susana R. Louros, Natasha J. Anstey, Miguel A. Gonzalez‐Lozano, Callista B. Harper, Nicholas Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Rate of protein synthesis is reduced in peripheral blood mononuclear cells (PBMCs) from Fragile X individuals
    Olivier Dionne, Audrey Lortie, Florence Gagnon, François Corbin · 2020 · Research Square
  10. FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1
    Suna Jung, Sneha Shah, Geongoo Han, Joel D. Richter · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus
    Stephanie A. Barnes, Aurore Thomazeau, Peter S.B. Finnie, Maxwell J. Heinrich, Arnold J. Heynen, Noboru H. Komiyama, Seth G. N. Grant, Frank S. Menniti, Emily K. Osterweil, Mark F. Bear · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Astrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndrome
    Lara Bergdolt, Alexandria Anding, Ola Alshaqi, Zahra Arbabi, Michael Douchey, Ember Eldridge, Katherine Hoffman, Ashley Reid, Kiran Sapkota, Ragunathan Padmashri et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome
    Timothy A. Fenton, Stela P. Petkova, Anna Adhikari, Jill L. Silverman · 2025 · Journal of Neurodevelopmental Disorders
  14. Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency
    Heng Li, Jennifer Ja-Yoon Choi, Eric Jinsheng Huang, Baoji Xu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Cell-intrinsic mechanisms underlying spontaneous activity in the mouse visual cortical slice: implications for fragile X pathophysiology
    Maxwell J. Heinrich, Mark F. Bear · 2025 · Journal of Neurophysiology
  16. Additional file 1 of Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment
    Kagistia Hana Utami, Nur Amirah Binte Mohammad Yusof, Jing Eugene Kwa, Peteri, Ulla-Kaisa, Maija L. Castrén, Pouladi, Mahmoud A. · 2020 · Figshare
  17. Additional file 6 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  18. Additional file 3 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  19. Additional file 2 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  20. Additional file 1 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  21. Additional file 5 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  22. Additional file 4 of Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
    Na, Han, Zheng, Yao-yao, Jia, Yaoning, Jingzhao Feng, Jizi Huang, Jihao Huang, Wang, Chang-Yun, Yao, Guangshan · 2024 · Figshare
  23. Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome
    Elisabetta Aloisi · 2015 · theses.fr (ABES)
  24. Développement cérébral postnatal, sommeil et activité épileptique : impact de l'invalidation de la sous-unité GluN2A des récepteurs NMDA impliquée dans le spectre des épilepsies-aphasies
    Manal Salmi · 2018 · theses.fr (ABES)
  25. Dissecting the role of calcium signaling in Fragile X syndrome
    Sara Castagnola · 2019 · theses.fr (ABES)
  26. Pathophysiological consequences of a Fragile X missense mutation
    Marta Prieto Garcia · 2020 · theses.fr (ABES)
  27. FYN, a Novel Target of Fragile X Mental Retardation Protein, Potentially Underlies ERK1/2 Hyperactivation in Fragile X Syndrome
    Wen Huang, Lin Jiang, Yanping Zhu, Ranhui Duan, Jin Xue, Qiuping Xia · 2026 · Molecular Neurobiology
  28. Effects of lovastatin on cortical excitability, E/I balance, and antioxidant markers in a case series of patients with drug-resistant epilepsy: a proof-of-concept study
    Sulaiman I. Abuhaiba, Isabel Catarina Duarte, Francisco Sales, Miguel S. Castelo-Branco · 2026 · Pharmacological Reports
  29. Blarcamesine improves EEG biomarkers of cortical dysfunction in a mouse model of fragile X syndrome
    Carrie R. Jonak, Samantha A. Assad, Devin K. Binder, James Tran, Christopher U. Missling, Walter E. Kaufmann · 2026 · Frontiers in Pharmacology
  30. Wiring the developing brain: The Rho GTPase signaling network in neurodevelopmental disorders
    Antonio Falace, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Morteza Doustmohammadi, Pasquale Striano, Federico Zara, Nanako Hamada, Koh‐ichi Nagata, Marcello Scala · 2026 · Neurobiology of Disease