Serotonin in the Modulation of Neural Plasticity and Networks: Implications for Neurodevelopmental Disorders
Open accessAbstract
Serotonin (5-HT) shapes brain networks during development and modulates a wide spectrum of essential neuronal functions ranging from perception and cognitive appraisal to emotional responses in the mature brain. Deficits in 5-HT-moderated synaptic signaling fundamentally impact the pathophysiology and long-term outcome of neurodevelopmental disorders. Our understanding of how 5-HT-dependent modulation of circuit configuration influences social cognition and emotional learning has been enhanced by recent insight into the molecular and cellular mechanisms of synapse formation and plasticity. In this review, we discuss emerging concepts as to how defects in synaptic plasticity impact our biosocial brain and how recent findings regarding 5-HT's role in brain development and function provide insight into the cellular and physiological basis of neurodevelopmental disorders.
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5-HT shapes neuronal networks during development.
“Clear-cut data demonstrate that 5-HT shapes neuronal networks during development and deficiencies thereby fundamentally impact the pathophysiology and long-term outcome of brain disorders (Lesch and Waider, 2012).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Lesch and Waider, 2012
Deficiencies in 5-HT fundamentally impact the pathophysiology and long-term outcome of brain disorders.
“Clear-cut data demonstrate that 5-HT shapes neuronal networks during development and deficiencies thereby fundamentally impact the pathophysiology and long-term outcome of brain disorders (Lesch and Waider, 2012).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Lesch and Waider, 2012
Malfunction of developmental plasticity may lead to cortical malfunctions and dystrophic serotonergic neurons as observed in neurodevelopmental disorders.
“Malfunction of developmental plasticity may lead to cortical malfunctions and dystrophic serotonergic neurons as observed in neurodevelopmental disorders (Gaspar et al., 2003;Lesch and Waider, 2012;Whitaker-Azmitia, 2001).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Lesch and Waider, 2012
5-HT is linked to cell adhesion molecules that are part of the extracellular matrix and crucial for developmental plasticity.
“Moreover, 5-HT is linked to cell adhesion molecules (Lesch and Waider, 2012), which are part of the extracellular matrix and crucial for developmental plasticity (Varea et al., 2007).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Lesch and Waider, 2012
5-HT interacts with synaptic adhesion molecules.
“Another line of evidence suggests that 5-HT interacts with synaptic adhesion molecules (Lesch and Waider, 2012).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Lesch and Waider, 2012
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References 174 · Cited by 435
- Authors
- Lesch, K.-P., & Waider, J.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Lesch, Klaus-Peter
- ORCID
- Lesch, Klaus-Peter
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 175-191
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2070615835
- Cited by
- 435
- References
- 174
- Citations by year
- 2026: 29 · 2025: 39 · 2024: 38 · 2023: 35 · 2022: 26 · 2021: 39 · 2020: 31 · 2019: 32 · 2018: 25 · 2017: 32 · 2016: 29 · 2015: 29 · 2014: 30 · 2013: 19 · 2012: 1
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonin, neuroplasticity, synaptic plasticity, neurodevelopmental disorders, brain development, social cognition, emotional learning, synaptogenesis, synaptic signaling, emotional responses
- MeSH terms
- Animals, Developmental Disabilities, Humans, Nerve Net, Neuronal Plasticity, Serotonin
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