Neuropeptide Transmission in Brain Circuits
Open accessAbstract
Neuropeptides are found in many mammalian CNS neurons where they play key roles in modulating neuronal activity. In contrast to amino acid transmitter release at the synapse, neuropeptide release is not restricted to the synaptic specialization, and after release, a neuropeptide may diffuse some distance to exert its action through a G protein-coupled receptor. Some neuropeptides such as hypocretin/orexin are synthesized only in single regions of the brain, and the neurons releasing these peptides probably have similar functional roles. Other peptides such as neuropeptide Y (NPY) are synthesized throughout the brain, and neurons that synthesize the peptide in one region have no anatomical or functional connection with NPY neurons in other brain regions. Here, I review converging data revealing a complex interaction between slow-acting neuromodulator peptides and fast-acting amino acid transmitters in the control of energy homeostasis, drug addiction, mood and motivation, sleep-wake states, and neuroendocrine regulation.
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Neuropeptides are major agents for intercellular communications in the brain.
“Neuropeptides are also major agents for intercellular communications in the brain58,59.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [59]
Absent comprehensive expression data combining whole-genome depth with single-cell resolution, it has been difficult to generate specific and testable hypotheses regarding cortical neuropeptide function and to design robust experiments to test those hypotheses.
“Absent such data, it has been difficult to generate specific and testable hypotheses regarding cortical neuropeptide function and to design robust experiments to test those hypotheses (Tremblay et al., 2016; van den Pol, 2012).”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as van den Pol, 2012
There has been a critical lack of comprehensive expression data combining whole-genome depth with single-cell resolution.
“There has been a critical lack, however, of comprehensive expression data combining whole-genome depth with single-cell resolution.”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as van den Pol, 2012
Magnocellular and parvocellular OT neuronal subtypes can be differentiated by a number of characteristic features.
“magnocellular and parvocellular OT neuronal subtypes can be differentiated by a number of characteristic features (van den Pol, 2012)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as van den Pol, 2012
Only magnocellular OT neurons send axonal projections outside the blood-brain barrier to the posterior pituitary.
“only magnocellular OT neurons send axonal projections outside of the blood-brain barrier (BBB) to the posterior pituitary (van den Pol, 2012)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as van den Pol, 2012
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References 220 · Cited by 810
- Authors
- van den Pol, A. N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 98-115
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3918222
- OpenAlex
- W1995087873
- Cited by
- 810
- References
- 220
- Citations by year
- 2026: 62 · 2025: 74 · 2024: 83 · 2023: 75 · 2022: 68 · 2021: 85 · 2020: 64 · 2019: 57 · 2018: 68 · 2017: 47 · 2016: 39 · 2015: 32 · 2014: 26 · 2013: 26 · 2012: 3
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK084052, R01DK084052)
- National Institute of Neurological Disorders and Stroke (R01NS048476, NS079274, R01NS041454, NS48476, R01NS079274)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuropeptides, neuropeptide release, G protein-coupled receptors, hypocretin/orexin, neuropeptide Y, neuromodulation, amino acid neurotransmitters, energy homeostasis, drug addiction, sleep-wake states, neuroendocrine regulation, brain circuits
- MeSH terms
- Animals, Central Nervous System, Humans, Neurons, Neuropeptides
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