Dopaminergic modulation of synaptic transmission in cortex and striatum
Open accessAbstract
Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. Perturbations of DA signaling are implicated in the pathogenesis or exploited in the treatment of many neuropsychiatric diseases, including Parkinson's disease (PD), addiction, schizophrenia, obsessive compulsive disorder, and Tourette's syndrome. Although the precise mechanisms employed by DA to exert its control over behavior are not fully understood, DA is known to regulate many electrical and biochemical aspects of neuronal function including excitability, synaptic transmission, integration and plasticity, protein trafficking, and gene transcription. In this Review, we discuss the actions of DA on ionic and synaptic signaling in neurons of the prefrontal cortex and striatum, brain areas in which dopaminergic dysfunction is thought to be central to disease.
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The motor symptoms of Parkinson's disease may result from decreased dopamine and serotonin levels.
“The motor symptoms of PD may result from decreased dopamine and serotonin levels [41,42].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [41]
These neuromodulators regulate social behavior through alterations in neuronal activity at key nodes of the mesolimbic reward system.
“Together, a body of work supported the idea that these neuromodulators regulate social behavior through alterations in neuronal activity at key nodes of the mesolimbic reward system [19,20].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [19]
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References 211 · Cited by 756
Research works printed but not linked: 3
- Fisone G 2010 Intracellular dopamine signaling Dopamine Handbook New York Oxford University Press 100 117
- Rankin ML Hazelwood LA Free RB Namkung Y Rex EB Roof RA Sibley DR Iversen LL Dunnett SB Iversen SD Bjorklund A Dopamine Handbook 2010 Molecular pharmacology of the dopamine receptors New York Oxford University Press 63 87
- Wickens J Arbuthnott G Dunnett SB Bentivoglio M Bjorklund A Hokfelt T 2005 Structural and functional interactions in the striatum at the receptor level Dopamine San Diego Elsevier 199 236
- Authors
- Tritsch, N. X., & Sabatini, B. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sabatini, Bernardo L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 33-50
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4386589
- OpenAlex
- W2043292527
- Cited by
- 756
- References
- 211
- Citations by year
- 2026: 37 · 2025: 57 · 2024: 79 · 2023: 60 · 2022: 43 · 2021: 72 · 2020: 53 · 2019: 46 · 2018: 68 · 2017: 53 · 2016: 60 · 2015: 47 · 2014: 51 · 2013: 27 · 2012: 2
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R01NS046579, R37NS046579, NS046579)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine, dopaminergic modulation, synaptic transmission, prefrontal cortex, striatum, neuromodulation, Parkinson's disease, addiction, schizophrenia, neuropsychiatric disorders, neuronal excitability, synaptic plasticity
- MeSH terms
- Animals, Brain, Dopamine, Humans, Synaptic Transmission, Neurons
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