ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

Suh, Jaehong, Choi, Se Hoon, Romano, Donna M., Gannon, Moira A., Lesinski, Andrea N., Kim, Doo Yeon, Tanzi, Rudolph E.·2013·Neuron

DOI 10.1016/j.neuron.2013.08.035

Cited by (220)

Items 101–200 of 220

Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats
Juan Huang, Nanqu Huang, Minghui Zhang, Jing Nie, Yun‐Yan Xu, Qin Wu, Jingshan Shi · 2019 · PeerJ
Upregulation of Alzheimer’s Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo
Yingxia Liang, Frank Raven, Joseph F. Ward, Sherri Y. Zhen, Siyi Zhang, Haoqi Sun, Sean Miller, Se Hoon Choi, Rudolph E. Tanzi, Can Martin Zhang · 2020 · Journal of Alzheimer s Disease
Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report
Serge G. Gauthier, Paul S. S. Aisen, Jeffrey L. Cummings, Michael J. Detke, Frank M. Longo, Rema Raman, Marwan Noel Sabbagh, Lon S. Schneider, Rudolph E. Tanzi, Pierre N. Tariot et al. · 2020 · The Journal of Prevention of Alzheimer s Disease
Methyl-CpG Binding Protein 2 in Alzheimer Dementia
Baeksun Kim, Yunjung Choi, Hye-Sun Kim, Heh‐In Im · 2019 · International Neurourology Journal
α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease
Pablo Agüero, María José Sainz, María‐Salud García‐Ayllón, Javier Sáez‐Valero, Raquel Téllez, Rosa Guerrero, Julián Pérez‐Pérez, Adriano Jiménez‐Escrig, Estrella Gómez‐Tortosa · 2020 · Alzheimer s Research & Therapy
Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APPswe/PS1ΔE9 mice
Sandrine Joly, Simon Lamoureux, Vincent Pernet · 2017 · Neurobiology of Aging
The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases
Fengjuan Jiao, Bojie Zhou, Lingyan Meng · 2022 · CNS Neuroscience & Therapeutics
Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment
Yiping Yang, Jie Zhang, Xiaobo Yang, Zhiying Li, Jian Wang, Cailing Lu, Aruo Nan, Yunfeng Zou · 2021 · Ecotoxicology and Environmental Safety
Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage
Wen Yao, Marc D. Tambini, Xinran Liu, Luciano D'adamio · 2019 · Journal of Neuroscience
Low‐variance RNAs identify Parkinson's disease molecular signature in blood
Maria D. Chikina, Christophe Gerald, Xianting Li, Yongchao Ge, Hanna Pinças, Venugopalan D. Nair, Aaron K. Wong, Arjun Krishnan, Olga G. Troyanskaya, Deborah Raymond et al. · 2015 · Movement Disorders
Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Chao Song, Shufang Li, Yingren Mai, Linpeng Li, Guoku Dai, Yuan Zhou, Xiaosheng Liang, Olivia Meilan Zou, Ya Wang, Libing Zhou et al. · 2024 · Journal of Neuroinflammation
Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis
Antonella De Lillo, Gita A. Pathak, Flavio De Angelis, Marco Di Girolamo, Marco Luigetti, Mario Sabatelli, Federico Perfetto, Sabrina Frusconi, Dario Manfellotto, Maria Fuciarelli et al. · 2020 · Clinical Epigenetics
Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner
Xiangshu Cheng, Fang-Xiao Shi, Kun-Peng Zhao, Wang Lin, Xiao-Ying Li, Jun Zhang, Yao-Yao Bu, Rui Zhu, Xiao-Hong Li, Dong-Xiao Duan et al. · 2021 · Aging
The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease
Richard J. Elsworthy, Eric James Hill, Connor Dunleavy, Sarah Aldred · 2022 · Frontiers in Aging Neuroscience
Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease.
Jun Chang, Zi-Hang Feng, Yu-Jiao Li, Honglin Lv, Shu-Zhen Liu, Yong-Yin Luo, Nan Hao, Lan Zhao, Jian-Wei Liu · 2024 · Biochemical Pharmacology
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein
Jian Chen, Biao Luo, Bi‐Rou Zhong, Kunyi Li, Qi‐Xin Wen, Song Li, Xiaojiao Xiang, Gui‐Feng Zhou, Li‐Tian Hu, Xiaojuan Deng et al. · 2020 · Genes & Diseases
APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice
Danny Baltissen, Charlotte S. Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J. Buchholz, Martin Körte, Ulrike Müller · 2023 · Frontiers in Cellular Neuroscience
Pharmacogenomics of Dementia: Personalizing the Treatment of Cognitive and Neuropsychiatric Symptoms
Barbara Vuić, Tina Milos, Lucija Tudor, Matea Nikolac Perković, Marcela Konjevod, Gordana Nedić Erjavec, Vladimir Farkaš, Suzana Uzun, Ninoslav Mimica, Dubravka Švob Štrac · 2023 · Genes
Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling
Swaroop Thonda, Srinivas N. Puttapaka, Swathi V. Kona, Shasi V. Kalivendi · 2021 · ACS Chemical Neuroscience
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality
Florian Christoph Sigloch, Julia Daniela Knopf, Juliane Weißer, Alejandro Gomez‐Auli, Martin Lothar Biniossek, Agnese Petrera, Oliver Schilling · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology
Ben Readhead, Jean‐Vianney Haure‐Mirande, Bin Zhang, Vahram H. Haroutunian, Sam Gandy, E E Schadt, Joel T. Dudley, M E Ehrlich · 2015 · Molecular Psychiatry
Towards a Unitary Hypothesis of Alzheimer’s Disease Pathogenesis
E. Area-Gómez, E. Schon · 2024 · Journal of Alzheimer's Disease
Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons
Kenji Yamamoto, Ryo Yamamoto, Nobuo Kato · 2021 · Frontiers in Aging Neuroscience
Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer’s disease
Toru Hosoi, Jun Nomura, K. Ozawa, A. Nishi, Y. Nomura · 2015 · Endoplasmic Reticulum Stress in Diseases
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model
Xinjian Zhu, Yuanyuan Yao, Jiurong Yang, Canyu Zhang, Xinyan Li, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan · 2021 · Free Radical Biology and Medicine
The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation
Mohammad Yasin Zamanian, Lusine Khachatryan, Mahzad Heidari, Razieh Darabi, Maryam Golmohammadi, Raed Fanoukh Aboqader Al-Aouadi, Esra Küpeli Akkol · 2025 · BioFactors
Shifting the balance: soluble ADAM10 as a potential treatment for Alzheimer's disease
Ayelet Sarah Hershkovits, Sivan Gelley, Rawad Hanna, Oded Kleifeld, Avidor Shulman, Ayelet Fishman · 2023 · Frontiers in Aging Neuroscience
Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology
Jesse R. Macyczko, Na Wang, Wenyan Lü, Suren Jeevaratnam, Francis Shue, Yuka A. Martens, Chia‐Chen Liu, Takahisa Kanekiyo, Guojun Bu, Yonghe Li · 2023 · Journal of Alzheimer s Disease
Common and Rare Genetic Variants Associated With Alzheimer's Disease
Hany E. S. Marei, Asmaa A. Al Thani, Jaana Suhonen, Mohamed Ezzat El Zowalaty, Mohammad A. Al-Banna, Carlo Cenciarelli, Tengfei Wang, Thomas Caceci · 2015 · Journal of Cellular Physiology
SHMT2 Mediates Small‐Molecule‐Induced Alleviation of Alzheimer Pathology Via the 5′UTR‐dependent ADAM10 Translation Initiation
Li Song, Qiuling Pan, Gui‐Feng Zhou, Shengwei Liu, Binglin Zhu, Peijia Lin, Xiaotong Hu, Jing‐Si Zha, Yan Long, Biao Luo et al. · 2024 · Advanced Science
Mechanistic Approach to Immunity and Immunotherapy of Alzheimer’s Disease: A Review
Md. Rubiath Islam, Md. Afser Rabbi, Tanbir Hossain, Sadia Sultana, Shihab Uddin · 2024 · ACS Chemical Neuroscience
sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl J. Föhr, Ludwig M. Lausser, Katja S. Kroker, Christian Proepper et al. · 2018 · Experimental Neurology
Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells
Belinda Yau, Zachary Blood, Yousun An, Zhiduan Su, Melkam Alamerew Kebede · 2019 · Scientific Reports
Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders
Michał Prendecki, Marta Kowalska, Ewa Totoń, Wojciech P. Kozubski · 2020 · Current Alzheimer Research
Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology
Yun Yang, Vı́ctor Tapias, Diana M. Acosta, Hui Xu, Huan‐Lian Chen, Ruchika P. Bhawal, Elizabeth Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Haploinsufficiency and Alzheimer’s Disease: The Possible Pathogenic and Protective Genetic Factors
Eva Bagyinszky, Seong Soo A. An · 2024 · International Journal of Molecular Sciences
Harnessing neurogenesis in the adult brain—A role in type 2 diabetes mellitus and Alzheimer’s disease
Orly Lazarov, R. Minshall, M. Bonini · 2020 · International review of neurobiology
The Genetic Basis of Alzheimer's Disease
Basavaraj V. Hooli, Rudolph E. Tanzi · 2016 · Elsevier eBooks
Alzheimer’s Disease and Dementia
Patrick Alfryn Lewis, Jennifer E. Spillane · 2018 · Elsevier eBooks
Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation
Sage Arbor · 2017 · Neural Regeneration Research
Massachusetts Alzheimer's Disease Research Center: Progress and challenges
Bradley T. Hyman, John H. Growdon, Mark W. Albers, Randy L. Buckner, Jasmeer P. Chhatwal, Teresa Gómez‐Isla, Christian Haass, Eloïse Hudry, Clifford R. Jack, Keith A. Johnson et al. · 2015 · Alzheimer s & Dementia
Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease
Lena Rehra, Susanne Erdinger, Lelia Wagner, Danny Baltissen, Jennifer Just, Leo König, Eric Mühlberg, Tom Eisenzapf, Lara Kilian, Marija Banićević et al. · 2025 · Journal of Controlled Release
Phosphodiesterase 4D Gene Modifies the Functional Network of Patients With Mild Cognitive Impairment and Alzheimer’s Disease
Jie Xiang, Xin Wang, Yuan Gao, Ting Li, Rui Cao, Ting Yan, Yunxiao Ma, Yan Niu, Jiayue Xue, Bin Wang · 2020 · Frontiers in Genetics
Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons
Hung‐En Hsia, Johanna Tüshaus, Xiao Ming Feng, Laura I. Hofmann, Benedikt Wefers, Denise K. Marciano, Wolfgang Wurst, Stefan F. Lichtenthaler · 2021 · The FASEB Journal
ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels
Pablo Agüero, Julián Pérez‐Pérez, Lucía Cremades‐Jimeno, María‐Salud García‐Ayllón, Adriana Gea‐González, María José Sainz, Ignacio Mahíllo, Raquel Téllez, Blanca Cárdaba, Javier Sáez‐Valero et al. · 2023 · International Journal of Molecular Sciences
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPARα
Hongjie Wang, Mohan Kumar Muthu Karuppan, Madhavan Nair, Madepalli Krishnappa Lakshmana · 2021 · Molecular Neurobiology
Neuroprotective role of herbal alternatives in circumventing Alzheimer’s disease through multi-targeting approach - a review
Sunil K. Ravi, Balenahalli Narasingappa Ramesh, Shilpa Kj, Jagadeesha Poyya, Jyothsna Karanth, Narayanappa Govinda Raju, Chandrashekhar G. Joshi · 2022 · Egyptian Journal of Basic and Applied Sciences
Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease
Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He · 2023 · Reviews in the Neurosciences
Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease
Vanessa Alexandre-Silva, Márcia R. Cominetti · 2024 · Mechanisms of Ageing and Development
Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis
Sofia I. Petersen, Rachel K. Okolicsanyi, Larisa Margaret Haupt · 2024 · Cellular and Molecular Neurobiology
Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells
Geoffray Leriche, Allen C. Chen, Sumin Kim, Dennis J. Selkoe, Jerry Yang · 2015 · ACS Chemical Neuroscience
The Genetic Basis of Alzheimer’s Disease
Basavaraj V. Hooli, Rudolph E. Tanzi · 2016 · Elsevier eBooks
Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease
Genevieve M. Evin, Adel Barakat · 2014 · Degenerative Neurological and Neuromuscular Disease
Monocular denervation of visual nuclei modulates APP processing and sAPPα production: A possible role on neural plasticity
Juliana Ferreira Vasques, Pedro Vinícius Bastos Heringer, Renata Guedes de Jesus Gonçalves, Paula Campello‐Costa, Claudio Alberto Serfaty, Adriana da Cunha Faria‐Melibeu · 2017 · International Journal of Developmental Neuroscience
The Role of Genetics in Alzheimer's Disease and Parkinson's Disease
Tenielle Porter, Aleksandra Gozt, Francis L. Mastaglia, Simon Matthew Laws · 2019 · Wiley eBooks
Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis
Zhiqiang Xu, Huang Huang, Yali Chen, Yun-Ying Gao, Jun Xu, Charles Marshall, Zhiyou Cai, Ming Xiao · 2016 · Journal of Alzheimer s Disease
Targeting ADAM10 in Renal Diseases
Jie-Na Wang, Xiao-Jing Cao · 2022 · Current Molecular Medicine
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
Manae Tatsumi, Takayuki Kishi, Satoru Ishida, Hiroki Kawana, Akiharu Uwamizu, Yuki Ono, Kouki Kawakami, Junken Aoki, Asuka Inoue · 2023 · PLoS ONE
The role of immunity and neuroinflammation in genetic predisposition and pathogenesis of Alzheimer’s disease
Seoyoung Yoon, Yong‐Ku Kim · 2015 · Global Medical Genetics
Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques
Qiong Pan, Hao Hu, Liangrong Han, Xin Jing, Hailiang Liu, Chuanchun Yang, Fengting Zhang, Yue Hu, Hongni Yue, Ying Ning · 2016 · PLoS ONE
Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating α-secretase
Qiaoyun Ren, Susu Wang, Junru Li, Kun Cao, Mei Zhuang, Miao Wu, Junhua Geng, Zhengping Jia, Wei Xie, An Liu · 2024 · Journal of Neuroscience
Melatoninergic Pathways in Alzheimer's Disease
G. Maes · 2015 · BENTHAM SCIENCE PUBLISHERS eBooks
Alzheimer’s Disease: Causes, Mechanisms, and Steps Toward Prevention
Se Hoon Choi, Rudolph E. Tanzi · 2020 · Oxford University Press eBooks
QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice
Mariana G. Fronza, Manoela Sacramento, Diego A.C. Alves, Domenico Praticò, Lucielli Savegnago · 2022 · Molecular Neurobiology
APP as an innate injury-response molecule
Zachary T. Olmsted, Michael V. Sofroniew · 2026 · Neurobiology of Disease
Genetic and Epigenetic Architecture of Alzheimer’s Dementia
Laura Cervera‐Carles, Jordi Clarimón · 2016 · Current Genetic Medicine Reports
Computational analysis and molecular dynamics simulation of high-risk single nucleotide polymorphisms of the ADAM10 gene
Jannatun Nayem Namme, Hasan Mahmud Reza, Asim Kumar Bepari · 2023 · Journal of Biomolecular Structure and Dynamics
Deciphering the Role of Peroxisome Proliferator-activated Receptor α and Phosphodiesterase Type 5 Targets in Alzheimer's Disease
Parnika M. Sose, Pravin Popatrao Kale, Gaurav Doshi · 2023 · CNS & Neurological Disorders - Drug Targets
Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy
Bruno Vasconcelos, Matthew Bird, Ilie‐Cosmin Stancu, Dick Terwel, Ilse Dewachter · 2017 · Elsevier eBooks
Genome sequencing for early-onset dementia: high diagnostic yield and frequent observation of multiple contributory alleles
J. Nicholas Cochran, Emily McKinley, Meagan Cochran, Michelle D. Amaral, Bryan A. Moyers, Brittany N. Lasseigne, David E. Gray, James M.J. Lawlor, Jeremy W. Prokop, Ethan G. Geier et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites
Colin H. Lipper, Emily D. Egan, Khal-Hentz Gabriel, Stephen C. Blacklow · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein
Yejin Shin, Kang-Sug Jo, Minseok Shin, Duri Lee, Hyejin Yeo, Youngsup Song, Sang‐Wook Kang · 2022 · Redox Biology
An overview of the role of MMP-8 and ADAM-33 in bronchial asthma
Kahan Celik, Tanya Tacheva, Dimo Dimov, Tatyana Ivanova Vlaykova · 2024 · Biotechnology & Biotechnological Equipment
From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer’s disease
Pinar Peyvand, Pantea Allami, Nima Rezaei · 2025 · Reviews in the Neurosciences
Biomarkers for Alzheimer's Disease and Potential Future Directions
Usman Zafar Paracha, Ishtiaq Qadri, Khezar Hayat, Talib Hussain · 2013
Risk Factors for Alzheimer’s Disease
Dongming Cai, Farida El Gaamouch · 2016 · InTech eBooks
Genetics of Alzheimer's disease: an update
M. Tang, C. Reitz · 2017 · Future Neurology
Basics of amyloid β-protein in Alzheimer’s disease
Azusa Sugimoto, Kenjiro Ono · 2022 · Elsevier eBooks
ADAM10: α-secretase in Alzheimer’s disease and regulator of neurobiology
Paul Säftig, Johannes Prox · 2014 · e-Neuroforum
PROGRAMA PARA EL ENTRENAMIENTO DE LA ACTIVIDAD COGNITIVA EN EL ADULTO MAYOR
Osvaldo León Bravo, Dotmaro Valdés Camacho, Pedro Antonio Valdes-Sosa, Dionisio Zaldívar Pérez · 2018 · Impetus
Paul Greengard, Ph.D. (1925‐2019)
Sam Gandy, Toshiharu Suzuki · 2019 · Alzheimer s & Dementia
Glutamine 666 renders murine ADAM10 an inefficient S. aureus α-toxin receptor
Gisela von Hoven, Martina Meyenburg, Claudia Neukirch, Daniel Siedenschnur, Matthias Husmann · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2
Kristin T. Jacobsen · 2013 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Shedding the Epilepsy Comorbidity in Alzheimer's Disease
Elizabeth M. Powell · 2014 · Epiliepsy currents/Epilepsy currents
Identification of ADAM10 5`UTR binding proteins - The RNA-binding protein Unr is involved in ADAM10 mRNA stability
Christian Haass · 2014
Effects of DHA and EGCG on the alpha-secretase mediated processing of APP
Hawmid Azizi · 2015 · The Atrium (University of Guelph)
Loss of Ataxin-1 Elevates BACE1 Expression and Impairs Axonal Targeting in the Cerebrum
Jaehong Suh, Donna Romano, Scott P. Herrick, Basavaraj V. Hooli, Mary K. Oram, Kristina Mullin, Wilma Wasco, Jeremy Dan Schmahmann, Mark W. Albers, Rudolph E. Tanzi · 2018 · SSRN Electronic Journal
Implications of alpha- and beta-secretase expression and function in Alzheimer's disease
Sven Reinhardt, K. Endres · 2020 · Elsevier eBooks
The effect of genes and diet on Alzheimer's disease-related molecular mechanisms : Influence of ubiquilin-1 and dietary lipids
Mari Takalo · 2015 · UEF eRepo (University of Eastern Finland)
Peer Review #1 of "Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats (v0.2)"
2019 · PeerJ
Peer Review #2 of "Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats (v0.1)"
2019 · PeerJ
Peer Review #1 of "Dendrobium alkaloids decrease Aβ by regulating α- and β-secretases in hippocampal neurons of SD rats (v0.1)"
2019 · PeerJ
The Role and Therapeutic Potential of α-secretase in Alzheimer’s Disease
Vandana Peddapalli, Patricija van Oosten‐Hawle · 2023 · Journal of Student Research
Is it possible to maintain a plaque-free healthy brain by treadmill?
Swarupa Pahan, Kalipada Pahan · 2024 · Neural Regeneration Research
A Valuable Target for Therapy: The Metalloproteinase ADAM10
Siddhant Tripathi, Yashika Sharma, Dileep Kumar · 2025 · Current Protein and Peptide Science
Mechanism of synergistic enhancement of α-secretase (ADAM10) activity by EGCG and FA
Yvning Guan, Wen Xu, Hongqi Ai · 2025 · ChemPhysMater
Revealing the nervous system requirements of Alzheimer’s disease risk genes in Drosophila
Jennifer Deger, Shabab B. Hannan, Mingxue Gu, Colleen E Strohlein, Lindsey D. Goodman, Sasidhar Pasupuleti, Zahid Shaik, Liwen Ma, Yarong Li, Jiayang Li et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Additional file 3 of Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis
Antonella De Lillo, Pathak, Gita A., De Angelis, Flavio, Di Girolamo, Marco, Marco Luigetti, Mario Sabatelli, Federico Perfetto, Sabrina Frusconi, Dario Manfellotto, Maria Fuciarelli et al. · 2020 · Figshare
Additional file 5 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Chao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Libing Zhou et al. · 2024 · Figshare
Additional file 3 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
Chao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Libing Zhou et al. · 2024 · Figshare