Activity-dependent neural plasticity from bench to bedside
Open accessAbstract
Much progress has been made in understanding how behavioral experience and neural activity can modify the structure and function of neural circuits during development and in the adult brain. Studies of physiological and molecular mechanisms underlying activity-dependent plasticity in animal models have suggested potential therapeutic approaches for a wide range of brain disorders in humans. Physiological and electrical stimulations as well as plasticity-modifying molecular agents may facilitate functional recovery by selectively enhancing existing neural circuits or promoting the formation of new functional circuits. Here, we review the advances in basic studies of neural plasticity mechanisms in developing and adult nervous systems and current clinical treatments that harness neural plasticity, and we offer perspectives on future development of plasticity-based therapy.
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Neural plasticity is the ability of the nervous system (during development and in the adult brain) to adopt a new functional or structural state in response to extrinsic and intrinsic factors.
“Broadly defined, neural plasticity is the ability of the nervous system (during development and in the adult brain) to adopt a new functional or structural state in response to extrinsic and intrinsic factors [9].”
Maladaptive neural plasticity also exists and may account for many developmental and acquired mental afflictions as well as neurodegenerative brain disorders.
“Maladaptive neural plasticity also exists and may account for many developmental and acquired mental afflictions as well as neurodegenerative brain disorders [9].”
Behavioral experience as repeated synaptic activity may have long-lasting structural and functional effects on the neural circuits of the brain including alterations in dendritic trees, growth of new axons, and the formation of new synapses via neural plasticity.
“Thus behavioral experience as repeated synaptic activity may have long-lasting structural and functional effects on the neural circuits of the brain including alterations in dendritic trees, growth of new axons, and the formation of new synapses via neural plasticity.”
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References 180 · Cited by 202
- Authors
- Ganguly, K., & Poo, M.-M.
- Affiliations
- San Francisco VA Medical Center (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Ganguly, Karunesh
- Poo, Mu-ming
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Issue
- 3
- Pages
- 729-741
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1994849008
- Cited by
- 202
- References
- 180
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 9 · 2023: 10 · 2022: 22 · 2021: 18 · 2020: 18 · 2019: 18 · 2018: 15 · 2017: 21 · 2016: 15 · 2015: 15 · 2014: 10 · 2013: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (1009855)
- U.S. Department of Veterans Affairs
- National Institute of Neurological Disorders and Stroke (R01NS036999, NS 36999)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- activity-dependent plasticity, neuroplasticity, neural circuit development, adult brain plasticity, brain disorders, functional recovery, electrical stimulation, behavioral experience, translational neuroscience
- MeSH terms
- Action Potentials, Animals, Brain, Brain Diseases, Brain Mapping, Humans, Nerve Net, Neuronal Plasticity, Neurons
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