The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Descending Control of Swim Posture by a Midbrain Nucleus in Zebrafish
Open accessAbstract
The reticular formation in the brainstem controls motor output via axonal projections to the hindbrain and spinal cord. It remains unclear how individual groups of brainstem neurons contribute to specific motor functions. Here, we investigate the behavioral role of the nucleus of the medial longitudinal fasciculus (nMLF), a small group of reticulospinal neurons in the zebrafish midbrain. Calcium imaging revealed that nMLF activity is correlated with bouts of swimming. Optogenetic stimulation of neurons in the left or right nMLF activates the posterior hypaxial muscle and produces a graded ipsilateral tail deflection. Unilateral ablation of a subset of nMLF cells biases the tail position to the intact side during visually evoked swims, while sparing other locomotor maneuvers. We conclude that activity in the nMLF provides postural control of tail orientation and thus steers the direction of swimming. Our studies provide an example of fine-grained modularity of descending motor control in vertebrates.
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Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
The neural circuit for touch sensitivity in Caenorhabditis elegans
Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093
Locomotor repertoire of the larval zebrafish: swimming, turning and prey capture
Budick, S. A., & O’Malley, D. M. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.17.2565 · Cited by 499
Gahtan, E., Tanger, P., & Baier, H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2678-05.2005 · Cited by 350
Self-citationControl of visually guided behavior by distinct populations of spinal projection neurons
Orger, M. B., Kampff, A. R., Severi, K. E., Bollmann, J. H., & Engert, F. (2008) · Nature Neuroscience · doi:10.1038/nn2048 · Cited by 274
Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming
Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., & Higashijima, S.-I. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.066 · Cited by 186
Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish
Schoonheim, P. J., Arrenberg, A. B., Del Bene, F., & Baier, H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5193-09.2010 · Cited by 185
Self-citationCoordination and localization in spinal motor systems
Tresch, M. C., Saltiel, P., d’Avella, A., & Bizzi, E. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00189-3 · Cited by 167
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Huang, K.-H., Ahrens, M. B., Dunn, T. W., & Engert, F. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.044 · Cited by 133
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“While the MLR has yet to be identified in the larval zebrafish ( Severi et al., 2014 ), the midbrain tegmental nMLF has been shown to regulate swimming ( Severi et al., 2014 ; Thiele et al., 2014 ; Wang and McLean, 2014 ).”
Structure of the Zebrafish Locomotor Repertoire Revealed with Unsupervised Behavioral Clustering
Marques, J. C., Lackner, S., Félix, R., & Orger, M. B. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.002 · Cited by 245
The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action
Isa, T., Marquez-Legorreta, E., Grillner, S., & Scott, E. K. (2021) · Current Biology · doi:10.1016/j.cub.2021.04.001 · Cited by 206
dal Maschio, M., Donovan, J. C., Helmbrecht, T. O., & Baier, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.034 · Cited by 169
Self-citationBrainstem neurons that command mammalian locomotor asymmetries
Cregg, J. M., Leiras, R., Montalant, A., Wanken, P., Wickersham, I. R., & Kiehn, O. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0633-7 · Cited by 154
Metadata
- Authors
- Thiele, T. R., Donovan, J. C., & Baier, H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 83
- Issue
- 3
- Pages
- 679-691
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1995943364
- Cited by
- 198
- References
- 13
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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