Altered Cortical Ensembles in Mouse Models of Schizophrenia
Open accessAbstract
In schizophrenia, brain-wide alterations have been identified at the molecular and cellular levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied two mouse models of schizophrenia-relevant disease processes: chronic ketamine (KET) administration and Df(16)A+/-, modeling 22q11.2 microdeletions, a genetic variant highly penetrant for schizophrenia. Local field potential recordings in visual cortex confirmed gamma-band abnormalities similar to patient studies. Two-photon calcium imaging of local cortical populations revealed in both models a deficit in the reliability of neuronal coactivity patterns (ensembles), which was not a simple consequence of altered single-neuron activity. This effect was present in ongoing and sensory-evoked activity and was not replicated by acute ketamine administration or pharmacogenetic parvalbumin-interneuron suppression. These results are consistent with the hypothesis that schizophrenia is an "attractor" disease and demonstrate that degraded neuronal ensembles are a common consequence of diverse genetic, cellular, and synaptic alterations seen in chronic schizophrenia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several mouse models for both autism spectrum disorder and schizophrenia have large effects on PV-IN function.
“The Df (16)A± transgenic mouse and the LgDel(±) mouse, both of which model the 22q11.2deletion in humans [5,[40][41][42][43], the contactin associated protein 2 mouse [44][45][46], the neurexin transgene model [47], Shank models [20,[48][49][50], and platelet-derived growth factor receptor-beta (Pdgfrb) knockout mouse [51,52] are examples of models for both ASD and schizophrenia, which have large”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 91 · Cited by 175
- Authors
- Hamm, J. P., Peterka, D. S., Gogos, J. A., & Yuste, R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Hamm, Jordan P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 94
- Issue
- 1
- Pages
- 153-167.e8
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5394986
- OpenAlex
- W2605115788
- Cited by
- 175
- References
- 91
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 15 · 2023: 24 · 2022: 27 · 2021: 17 · 2020: 21 · 2019: 22 · 2018: 15 · 2017: 10
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Eye Institute (DP1EY024503, R01EY011787)
- National Alliance for Research on Schizophrenia and Depression (19944)
- National Institute of Mental Health (R01MH077235, R01MH101218, R41MH10089, F32-MH106265, R01MH100561, ROIMH096274)
- Defense Advanced Research Projects Agency (ARO MURI W911NF-12-1-0594, SIMPLEX N66001-15-C-4032)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, ketamine, 22q11.2 microdeletion, gamma oscillations, visual cortex, attractor dynamics, parvalbumin interneurons, calcium imaging, local field potentials, mouse model
- MeSH terms
- Action Potentials, Animals, Brain, DiGeorge Syndrome, Disease Models, Animal, Evoked Potentials, Visual, Interneurons, Ketamine, Neural Inhibition, Neurons, Parvalbumins, Schizophrenia, Visual Cortex, Mice, Knockout, Excitatory Amino Acid Antagonists, Mice, Gamma Rhythm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
