Wiring the Human Brain: A User’s Handbook
Open accessAbstract
Brain function requires connecting neuronal networks to empower movement, sensation, behavior, and cognition. Studies published early this year provide evidence that in humans, Netrin receptor, Deleted in Colorectal Cancer (DCC), is a master regulator of axonal crossing throughout the neuraxis.
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The DCC product guides axonal growth during neurodevelopment and acts as a master regulator of midline crossing and white matter projections.
“The product of DCC plays a key role in guiding axonal growth during neurodevelopment and serves as a master regulator of midline crossing and white matter projections (Bendriem and Ross, 2017).”
From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Bendriem and Ross, 2017
The most highly pleiotropic locus, with evidence of association with all eight disorders, maps within DCC.
“The most highly pleiotropic locus in our analyses, with evidence of association with all eight disorders, maps within DCC, a gene fundamental to the early development of white matter connections in the brain (Bendriem and Ross, 2017).”
From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Bendriem and Ross, 2017
Loss-of-function mutations in DCC cause severe neurodevelopmental syndromes involving loss of midline commissural tracts and diffuse disorganization of white matter tracts.
“Loss-of-function mutations in DCC cause severe neurodevelopmental syndromes involving loss of midline commissural tracts and diffuse disorganization of white matter tracts (Bendriem and Ross, 2017; Jamuar et al., 2017; Marsh et al., 2017).”
From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Bendriem and Ross, 2017
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Lee, P. H., Anttila, V., Won, H., Feng, Y.-C. A., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.020 · Cited by 1,381 · see citing works
“Loss-of-function mutations in DCC cause severe neurodevelopmental syndromes involving loss of midline commissural tracts and diffuse disorganization of white matter tracts (Bendriem and Ross, 2017; Jamuar et al., 2017; Marsh et al., 2017).”
Background
- Authors
- Bendriem, R. M., & Ross, M. E.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Ross, M. Elizabeth
- ORCID
- Ross, M. Elizabeth
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 95
- Issue
- 3
- Pages
- 482-485
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8274317
- OpenAlex
- W2741058142
- Cited by
- 15
- References
- 0
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2019: 3
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS105477)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD067244, T32HD060600)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- axon guidance, netrin receptors, DCC receptor, brain development, neuronal migration, neuraxis
- MeSH terms
- Netrin Receptors, Animals, Axons, Brain, Humans, Nerve Growth Factors, Neurons, Receptors, Cell Surface, Growth Cones
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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