Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

Madry, Christian; Kyrargyri, Vasiliki; Arancibia-Cárcamo, I. Lorena; Jolivet, Renaud; Kohsaka, Shinichi; Bryan, Robert M.; Attwell, David

doi:10.1016/j.neuron.2017.12.002

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

Summary Microglia exhibit two modes of motility: they constantly extend and retract their processes to survey the brain, but they also send out targeted processes to envelop sites of tissue damage. We now show that these motility modes differ mechanistically. We identify the two-pore domain chann…