Cocaine Place Conditioning Strengthens Location-Specific Hippocampal Coupling to the Nucleus Accumbens
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Abstract
Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP was associated with recruitment of D2-positive nucleus accumbens medium spiny neurons to fire in the cocaine-paired location, and this recruitment was driven predominantly by selective strengthening of coupling with hippocampal place cells that encode the cocaine-paired location. These findings provide in vivo evidence suggesting that the synaptic potentiation in the accumbens caused by repeated cocaine administration preferentially affects inputs that were active at the time of drug exposure. This provides a potential physiological mechanism by which drug use becomes associated with specific environmental contexts.
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Establishment of cocaine place preference is accompanied by potentiation of hippocampal-accumbens synaptic excitation.
“Similarly, establishment of cocaine place preferences is accompanied by a potentiation of hippocampal-NAc synaptic excitation [230].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [230]
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References 58 · Cited by 123
- Authors
- Sjulson, L., Peyrache, A., Cumpelik, A., Cassataro, D., & Buzsáki, G.
- Affiliations
- NYU Langone Health (US)
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Sjulson, Lucas
- Buzsáki, György
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 98
- Issue
- 5
- Pages
- 926-934.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6154491
- OpenAlex
- W2950234133
- Cited by
- 123
- References
- 58
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 19 · 2023: 14 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 18 · 2018: 7 · 2017: 1
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain and Behavior Research Foundation
- National Institutes of Health (K08 DA036657, MH107396)
- Leon Levy Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cocaine, conditioned place preference, hippocampus, nucleus accumbens, place cells, dopamine D2 receptor, medium spiny neurons, synaptic potentiation, addiction, environmental context
- MeSH terms
- Animals, Cocaine, Conditioning, Classical, Disease Models, Animal, Hippocampus, Interneurons, Neural Pathways, Neurons, Nucleus Accumbens, Receptors, Dopamine D2, Pyramidal Cells, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Mice, CA1 Region, Hippocampal
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