Cited by 195Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning

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Kaufman, Alexandra Mansell, Geiller, Tristan, Losonczy, Attila·2020·Neuron

DOI 10.1016/j.neuron.2019.12.029PMC PMC7265133

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Abstract

During spatial learning, hippocampal (HPC) place maps reorganize to represent new goal locations, but little is known about the circuit mechanisms facilitating these changes. Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1) regulates the overrepresentation of CA1 place cells near rewarded locations. Using two-photon calcium imaging, we monitored the activity of LC-CA1 fibers in the mouse dorsal HPC. We find that the LC-CA1 projection signals the translocation of a reward, predicting behavioral performance on a goal-oriented spatial learning task. An optogenetic stimulation mimicking this LC-CA1 activity induces place cell reorganization around a familiar reward, while its inhibition decreases the degree of overrepresentation around a translocated reward. Our results show that LC acts in conjunction with other factors to induce goal-directed reorganization of HPC representations and provide a better understanding of the role of neuromodulatory actions on HPC place map plasticity.

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Authors: Kaufman, A. M., Geiller, T., & Losonczy, A.
Affiliations: Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
Corresponding author: Losonczy, Attila
ORCID: Geiller, Tristan
Losonczy, Attila
Venue: Neuron
Publisher: Elsevier BV
Published: 2020-03
Volume: 105
Issue: 6
Pages: 1018-1026.e4
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2019.12.029
PMC: PMC7265133
OpenAlex: W3002023792
Cited by: 193
References: 53
Citations by year: 2026: 31 · 2025: 34 · 2024: 41 · 2023: 27 · 2022: 25 · 2021: 23 · 2020: 11
FWCI: 11.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Foundation for the National Institutes of Health
Kavli Foundation
National Science Foundation (DGE-1644869, 1F31MH117870-01A1)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: locus coeruleus, hippocampal CA1, place cells, neuromodulation, goal-directed learning, optogenetic stimulation
MeSH terms: Place Cells, Animals, Female, Locus Coeruleus, Male, Mice, Transgenic, Neural Inhibition, Neural Pathways, Reward, Mice, CA1 Region, Hippocampal, Optogenetics, Spatial Learning

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A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning

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