Post-error recruitment of frontal sensory cortical projections promotes attention in mice
Open accessAbstract
The frontal cortex, especially the anterior cingulate cortex area (ACA), is essential for exerting cognitive control after errors, but the mechanisms that enable modulation of attention to improve performance after errors are poorly understood. Here we demonstrate that during a mouse visual attention task, ACA neurons projecting to the visual cortex (VIS; ACA VIS neurons) are recruited selectively by recent errors. Optogenetic manipulations of this pathway collectively support the model that rhythmic modulation of ACA VIS neurons in anticipation of visual stimuli is crucial for adjusting performance following errors. 30-Hz optogenetic stimulation of ACA VIS neurons in anesthetized mice recapitulates the increased gamma and reduced theta VIS oscillatory changes that are associated with endogenous post-error performance during behavior and subsequently increased visually evoked spiking, a hallmark feature of visual attention. This frontal sensory neural circuit links error monitoring with implementing adjustments of attention to guide behavioral adaptation, pointing to a circuit-based mechanism for promoting cognitive control.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No statistical power estimation analyses were used to predetermine sample sizes; sample sizes were chosen to match previous publications.
“No statistical power estimation analyses were used to predetermine sample sizes, which instead were chosen to match previous publications (2, 11, 26-28).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 45 · Cited by 66
- Authors
- Norman, K. J., Riceberg, J. S., Koike, H., Bateh, J., McCraney, S. E., Caro, K., Kato, D., Liang, A., Yamamuro, K., Flanigan, M. E., Kam, K., Falk, E. N., Brady, D. M., Cho, C., Sadahiro, M., Yoshitake, K., Maccario, P., Demars, M. P., Waltrip, L., Varga, A. W., Russo, S. J., Baxter, M. G., Shapiro, M. L., Rudebeck, P. H., & Morishita, H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Albany Medical College (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Morishita, Hirofumi
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 109
- Issue
- 7
- Pages
- 1202-1213.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8035262
- OpenAlex
- W3133153199
- Cited by
- 66
- References
- 45
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 13 · 2023: 15 · 2022: 11 · 2021: 3
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- National Institute of Mental Health
- Beatrice and Samuel A. Seaver Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- anterior cingulate cortex, visual attention, cognitive control, error monitoring, visual cortex, gamma oscillations, theta oscillations, optogenetic stimulation, behavioral adaptation, mice
- MeSH terms
- Animals, Attention, Behavior, Animal, Electroencephalography, Frontal Lobe, Male, Mice, Inbred C57BL, Motor Activity, Neural Pathways, Neurons, Photic Stimulation, Psychomotor Performance, Reaction Time, Recruitment, Neurophysiological, Somatosensory Cortex, Visual Cortex, Mice, Electrophysiological Phenomena, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
