Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice
Abstract
Numerous animal and clinical studies have described memory deficits following sleep deprivation. There is also evidence that the absence of sleep increases brain oxidative stress. The present study investigates the role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice. Mice were sleep deprived for 72 h by the multiple platform method-groups of 4-6 animals were placed in water tanks, containing 12 platforms (3 cm in diameter) surrounded by water up to 1 cm beneath the surface. Mice kept in their home cage or placed onto larger platforms were used as control groups. The results showed that hippocampal oxidized/reduced glutathione ratio as well as lipid peroxidation of sleep-deprived mice was significantly increased compared to control groups. The same procedure of sleep deprivation led to a passive avoidance retention deficit. Both passive avoidance retention deficit and increased hippocampal lipid peroxidation were prevented by repeated treatment (15 consecutive days, i.p.) with the antioxidant agents melatonin (5 mg/kg), N-tert-butyl-alpha-phenylnitrone (200 mg/kg) or vitamin E (40 mg/kg). The results indicate an important role of hippocampal oxidative stress in passive avoidance memory deficits induced by sleep deprivation in mice.
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Seventy-two hours of platform sleep deprivation increases oxidative stress in the mouse hippocampus, as measured by increased lipid peroxidation and increased ratios of oxidized to reduced glutathione.
“Seventy-two hours of “flower pot” or platform sleep deprivation has been reported to increase oxidative stress in the mouse hippocampus, as measured by increased lipid peroxidation and increased ratios of oxidized to reduced glutathione.62”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [62]
Sleep deprivation using platform/flower pot methods impairs retention of passive avoidance memory, a context-dependent fear-memory task.
“Sleep deprivation using these methods also impairs retention of passive avoidance memory, a context-dependent, fear-memory task.62”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [62]
Sleep deprivation in mice for 72 hours by the flowerpot method increases oxidative stress in hippocampus, as measured by increased lipid peroxidation and increased ratios of oxidized to reduced glutathione.
“Sleep deprivation in mice for 72 hours by the “flowerpot” or platform method has been reported to increase oxidative stress in hippocampus, as measured by increased lipid peroxidation and increased ratios of oxidized to reduced glutathione.25”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [25]
Sleep deprivation by the platform method impairs retention of passive avoidance memory, impairs spatial memory in the Morris water maze, and reduces long-term potentiation in the CA1 region of the hippocampus.
“For example, sleep deprivation by the platform (or flowerpot) method resulted in impaired retention of passive avoidance memory, a context-dependent fear memory task,25 as well as impaired performance of spatial memory in the Morris water maze32 and a reduction in longterm potentiation in the CA1 region of the hippocampus.33”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [25]
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References 63 · Cited by 307
- Authors
- Silva, R. H., Abílio, V. C., Takatsu, A. L., Kameda, S. R., Grassl, C., Chehin, A. B., Medrano, W. A., Calzavara, M. B., Registro, S., Andersen, M. L., Machado, R. B., Carvalho, R. C., Ribeiro, R. D. A., Tufik, S., & Frussa-Filho, R.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Silva, R.H
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 46
- Issue
- 6
- Pages
- 895-903
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2030859315
- Cited by
- 307
- References
- 63
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 25 · 2020: 12 · 2019: 25 · 2018: 19 · 2017: 17 · 2016: 11 · 2015: 22 · 2014: 21 · 2013: 15 · 2012: 15
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, memory impairment, passive avoidance memory, lipid peroxidation, melatonin, N-tert-butyl-alpha-phenylnitrone, vitamin E, antioxidant treatment, mice
- MeSH terms
- Animals, Hippocampus, Male, Memory Disorders, Reaction Time, Sleep Deprivation, Oxidative Stress, Mice
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