Cited by 168Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and TreatmentsAntioxidant Activity and Oxidative Stress

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Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures

Dietrich, Jean-Bernard, Mangeol, Aude, Revel, Marie-Odile, Burgun, Claude, Aunis, Dominique, Zwiller, Jean·2005·Neuropharmacology

DOI 10.1016/j.neuropharm.2005.01.018

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Abstract

Either a single (acute) or repeated daily (chronic) injections (1 injection/day) of 20 mg/kg cocaine for 10 days to rats was found to increase reactive oxygen species production in two dopaminergic brain structures, the frontal cortex and the striatum. We found that the mitochondrial genome was down-regulated after acute cocaine injection. Hydroperoxide and lipid peroxide generation was correlated with an increase in mitochondrial hydrogen peroxide generation and with a reduced functioning of mitochondrial complex I in response to cocaine. As judged from the measurement of caspase-3 activity and TUNEL labeling, neither acute nor chronic cocaine treatment has been found to induce apoptosis in any of the structures examined. This differs dramatically from what has been described for methamphetamine. Cocaine-induced radical formation was accompanied by the induction of the antioxidant enzymes superoxide dismutase and glutathione peroxidase, after both acute and chronic cocaine treatment. In addition, proteasome chymotrypsin-like activity was enhanced following a single cocaine injection in both cortex and striatum. It is proposed that the compensatory mechanisms to oxidative stress occurring in response to cocaine were effective in scavenging reactive oxygen species and in preventing subsequent cellular damage, thus explaining why no significant cell death was found in these brain structures.

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Araújo, G. D. F., Costa, L. S. D. O., dos Santos, V. F., Cunha, D. L., da Silva, R. C., Marques, M., Maciel-Magalhães, M., Medeiros, R. J., Pereira, H. M. G., Correia, F. V., et al. (2026) · Aquatic Toxicology · doi:10.1016/j.aquatox.2026.108032

Authors: Dietrich, J.-B., Mangeol, A., Revel, M.-O., Burgun, C., Aunis, D., & Zwiller, J.
Affiliations: Inserm (FR)
Corresponding author: Dietrich, Jean-Bernard
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2005-06
Volume: 48
Issue: 7
Pages: 965-974
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2005.01.018
OpenAlex: W2061764945
Cited by: 168
References: 34
Citations by year: 2026: 8 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 16 · 2013: 11 · 2012: 8
FWCI: 2.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: cocaine, reactive oxygen species, oxidative stress, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, dopaminergic neurons, frontal cortex, striatum, mitochondrial hydrogen peroxide, mitochondrial complex I, lipid peroxidation, caspase-3, apoptosis, methamphetamine
MeSH terms: Animals, Antioxidants, Brain, Cocaine, Dopamine, Enzyme Induction, Glutathione Peroxidase, Male, Superoxide Dismutase, Rats, Wistar, Reactive Oxygen Species, Rats

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Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures

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