Lipid rafts, cholesterol, and the brain
Open accessAbstract
Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking. In this article, we provide an overview of current methods for studying lipid rafts and models for how lipid rafts might form and function. Next, we propose a potential mechanism for regulating lipid rafts in the brain via local control of cholesterol biosynthesis by neurotrophins and their receptors. Finally, we discuss evidence that altered cholesterol metabolism and/or lipid rafts play a critical role in the pathophysiology of multiple CNS disorders, including Smith-Lemli-Opitz syndrome, Huntington's, Alzheimer's, and Niemann-Pick Type C diseases.
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Increased brain cholesterol levels and dyslipidemias overall have been linked to Alzheimer's disease incidence.
“Increased brain cholesterol levels and dyslipidemias overall have been linked to AD incidence [49,55,100,107].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [107]
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References 143 · Cited by 342
- Authors
- Korade, Z., & Kenworthy, A. K.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Kenworthy, Anne K.
- ORCID
- Kenworthy, Anne K.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 55
- Issue
- 8
- Pages
- 1265-1273
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2638588
- OpenAlex
- W2071533902
- Cited by
- 342
- References
- 143
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 19 · 2023: 22 · 2022: 20 · 2021: 19 · 2020: 18 · 2019: 27 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 13 · 2014: 30 · 2013: 23 · 2012: 22
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01 GM72846, R01GM073846)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- lipid rafts, cholesterol, brain, membrane fluidity, membrane protein trafficking, neurotransmission, receptor trafficking, cholesterol biosynthesis, neurotrophins, neurotrophin receptors, cholesterol metabolism, Smith-Lemli-Opitz syndrome, Huntington's disease, Alzheimer's disease, Niemann-Pick disease type C, central nervous system disorders
- MeSH terms
- Animals, Brain, Cholesterol, Humans, Membrane Microdomains
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