Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing
Open accessAbstract
Despite a great deal of progress, more than 10% of pregnant women in the USA smoke. Epidemiological studies have demonstrated correlations between developmental tobacco smoke exposure and sensory processing deficits, as well as a number of neuropsychiatric conditions, including attention deficit hyperactivity disorder. Significantly, data from animal models of developmental nicotine exposure have suggested that the nicotine in tobacco contributes significantly to the effects of developmental smoke exposure. Consequently, we hypothesize that nicotinic acetylcholine receptors (nAChRs) are important for setting and refining the strength of corticothalamic-thalamocortical loops during critical periods of development and that disruption of this process by developmental nicotine exposure can result in long-lasting dysregulation of sensory processing. The ability of nAChR activation to modulate synaptic plasticity is likely to underlie the effects of both endogenous cholinergic signaling and pharmacologically administered nicotine to alter cellular, physiological and behavioral processes during critical periods of development.
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nAChRs play a role in maturation of circuits important for attention during development.
“many studies have shown a role for nAChRs in maturation of circuits important for attention during development (reviewed in Heath and Picciotto 2009).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Heath and Picciotto 2009
nAChRs in thalamo-cortico-thalamic loops are important for regulating glutamate release in this circuit and for mediating the effects of acetylcholine on attentional function.
“nAChRs in thalamo-cortico-thalamic loops are important for regulating glutamate release in this circuit, and for mediating the effects of acetylcholine on attentional function (Heath and Picciotto 2009).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Heath and Picciotto 2009
Children exposed to tobacco smoke during gestation exhibit non-clinical deficits in various cognitive domains.
“A number of studies have also shown that children exposed to tobacco smoke during gestation exhibit non-clinical deficits in various cognitive domains [3, 8–10].”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [3]
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References 122 · Cited by 99
- Authors
- Heath, C. J., & Picciotto, M. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Picciotto, Marina R.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 56
- Pages
- 254-262
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2635334
- OpenAlex
- W1991139008
- Cited by
- 99
- References
- 122
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 15 · 2012: 7
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Open Research Online (The Open University) (submittedVersion)
- Funders
- National Institute on Drug Abuse (K02DA000436, DA 10455, R29DA010455, R01DA010455, DA 00436, R37DA014241)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, synaptic plasticity, cholinergic system, critical period, sensory processing deficits, attention, attention deficit hyperactivity disorder, prenatal tobacco exposure
- MeSH terms
- Animals, Attention, Humans, Neural Pathways, Neuronal Plasticity, Nicotine, Receptors, Nicotinic, Sensation, Nicotinic Agonists
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