The role of fragile X mental retardation protein in major mental disorders
Open accessAbstract
Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP plays in neuronal cells, experiments from our own laboratory that demonstrate reductions of FMRP in additional psychiatric disorders (autism, schizophrenia, bipolar disorder, and major depressive disorder), and potential therapies to ameliorate the loss of FMRP. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'.
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Post mortem studies have shown that FMRP, the protein missing or deficient in FXS, is also deficient in the brain in patients with idiopathic ASD without a fragile X mutation.
“In addition, post mortem studies have shown that FMRP, the protein that is missing or deficient in FXS, is also deficient in the brain in patients with idiopathic ASD without a fragile X mutation [104, 105].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [105]
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References 82 · Cited by 80
Research works printed but not linked: 3
- Bauman ML Kemper TL Bauman M Kemper T 1994 Neuroanatomic observations of the brain in autism The neurobiology of autism Johns Hopkins University Press Baltimore, MD 19 145
- Hagerman RJ Hagerman RJ Cronister A 1996 Physical and behavioral phenotype Diagnosis, Treatment, and Research Baltimore The Johns Hopkins University Press, Baltimore, MD 3 87
- Kanai Y Dohmae N Hirokawa N 2004 Kinesin transcripts RNA; isolation and characterization of an RNA-transporting granule Neuron 43 513 525 15312650
- Authors
- Fatemi, S. H., & Folsom, T. D.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Fatemi, S. Hossein
- ORCID
- Fatemi, S. Hossein
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 60
- Issue
- 7-8
- Pages
- 1221-1226
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC3078953
- OpenAlex
- W2085938114
- Cited by
- 80
- References
- 82
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 13 · 2012: 11
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R24MH068855, R01MH086000)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R015HD052074-04, R01HD052074)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- FMRP, fragile X syndrome, FMR1 gene, autism spectrum disorder, schizophrenia, bipolar disorder, major depressive disorder, mental illness, mRNA-binding proteins, neurons
- MeSH terms
- Animals, Autistic Disorder, Mental Disorders, Cerebellum, Female, Fragile X Syndrome, Humans, Male, Intellectual Disability, Mice, Fragile X Messenger Ribonucleoprotein 1, Molecular Targeted Therapy
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