The DOI matches its Crossref record; 276 of the 276 references it cites were found in a registry or an index.
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
Open accessAbstract
Serotonergic hallucinogens produce profound changes in perception, mood, and cognition. These drugs include phenylalkylamines such as mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM), and indoleamines such as (+)-lysergic acid diethylamide (LSD) and psilocybin. Despite their differences in chemical structure, the two classes of hallucinogens produce remarkably similar subjective effects in humans, and induce cross-tolerance. The phenylalkylamine hallucinogens are selective 5-HT2 receptor agonists, whereas the indoleamines are relatively non-selective for serotonin (5-HT) receptors. There is extensive evidence, from both animal and human studies, that the characteristic effects of hallucinogens are mediated by interactions with the 5-HT2A receptor. Nevertheless, there is also evidence that interactions with other receptor sites contribute to the psychopharmacological and behavioral effects of the indoleamine hallucinogens. This article reviews the evidence demonstrating that the effects of indoleamine hallucinogens in a variety of animal behavioral paradigms are mediated by both 5-HT2 and non-5-HT2 receptors.
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Cites
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Cited by
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
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Hesselgrave, N., Troppoli, T. A., Wulff, A. B., Cole, A. B., & Thompson, S. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022489118 · Cited by 378
Metadata
- Authors
- Halberstadt, A. L., & Geyer, M. A.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 61
- Issue
- 3
- Pages
- 364-381
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2080123927
- Cited by
- 411
- References
- 276
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- green
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