Cited by 302Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

Gupta, Amit, Bisht, Bharti, Dey, Chinmoy Sankar·2011·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.01.033

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. Pharmacological treatments presently available can slow down the progression of symptoms but can not cure the disease. Currently there is widening recognition that AD is closely associated with impaired insulin signaling and glucose metabolism in brain, suggesting it to be a brain-specific form of diabetes and so also termed as "type 3 diabetes". Hence investigating the role of pharmacological agents that could ameliorate neuronal insulin resistance merit attention in AD therapeutics, however the therapeutics for pathophysiological condition like neuronal insulin resistance itself is largely unknown. In the present study we have determined the effect of metformin on neuronal insulin resistance and AD-associated characteristics in an in vitro model of "type 3 diabetes" by differentiating neuronal cell line Neuro-2a under prolonged presence of insulin. We observed that prolonged hyperinsulinemic conditions in addition to generating insulin resistance also led to development of hallmark AD-associated neuropathological changes. Treatment with metformin sensitized the impaired insulin actions and also prevented appearance of molecular and pathological characteristics observed in AD. The results thus demonstrate possible therapeutic efficacy of peripheral insulin-sensitizer drug metformin in AD by its ability to sensitize neuronal insulin resistance. These findings also provide direct evidences linking hyperinsulinemia and AD and suggest a unique opportunity for prevention and treatment of "type 3 diabetes".

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2011.01.033

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,052
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
The GSK3 hypothesis of Alzheimer’s disease
Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903
Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review
Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 766
Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine
Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8304 · Cited by 723

Flagged first, then by citations

Show all 61 references

Sorted by citations

Items 101–200 of 302

Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin
Rajasekar, N., Dwivedi, S., Nath, C., Hanif, K., & Shukla, R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.013 · Cited by 55
T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease
Tong, M., Deochand, C., Didsbury, J. R., & de la Monte, S. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151013 · Cited by 56
Vitamins D and E Stimulate the PI3K-AKT Signalling Pathway in Insulin-Resistant SK-N-SH Neuronal Cells
Zaulkffali, A. S., Razip, N. N. M., Alwi, S. S. S., Jalil, A. A., Mutalib, M. S. A., Gopalsamy, B., Chang, S. K., Zainal, Z., Ibrahim, N. N., Zakaria, Z. A., et al. (2019) · Nutrients · doi:10.3390/nu11102525 · Cited by 56
Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
Matthes, F., Hettich, M. M., Schilling, J., Flores-Dominguez, D., Blank-Stein, N., Wiglenda, T., Buntru, A., Wolf, H., Weber, S. S., Vorberg, I. M., et al. (2018) · Cell Death Discovery · doi:10.1038/s41420-017-0003-8 · Cited by 55
The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats
Hernandez, A. R., Hernandez, C. M., Campos, K. T., Truckenbrod, L. M., Sakarya, Y., McQuail, J. A., Carter, C. S., Bizon, J. L., Maurer, A. P., & Burke, S. N. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx193 · Cited by 52
Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Alqahtani, S. M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Alexiou, A. T., Papadakis, M., Hemeda, L. R., Faheem, S. A., & Batiha, G. E. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08857-x · Cited by 57
Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders
Chen, Q., Cao, T., Li, N., Zeng, C., Zhang, S., Wu, X., Zhang, B., & Cai, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.667874 · Cited by 50
Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia
Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022) · Pharmaceuticals · doi:10.3390/ph15030312 · Cited by 51
Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease
Kazkayası, İ., Telli, G., Nemutlu, E., & Uma, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120538 · Cited by 50
Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer’s Disease
Padhi, D., & Govindaraju, T. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00335 · Cited by 47
Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer’s Disease and Diabetes
Stanciu, G. D., Rusu, R. N., Bild, V., Filipiuc, L. E., Tamba, B.-I., & Ababei, D. C. (2021) · Biomedicines · doi:10.3390/biomedicines9050576 · Cited by 47
Type 2 Diabetes and Cognitive Compromise
Kravitz, E., Schmeidler, J., & Beeri, M. S. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.05.009 · Cited by 49
Enfermedad de Alzheimer y deterioro cognitivo asociado a la diabetes mellitus de tipo 2: relaciones e hipótesis
Domínguez, R. O., Pagano, M. A., Marschoff, E., González, S., Repetto, M. G., & Serra, J. A. (2013) · Neurología · doi:10.1016/j.nrl.2013.05.006 · Cited by 47
Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type
Malik, J., Munjal, K., & Deshmukh, R. R. (2014) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2014-0012 · Cited by 45
Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Dise ase Pathologies
Tong, M., & Dominguez, C. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000238 · Cited by 43
Role of Akt isoforms in neuronal insulin signaling and resistance
Sharma, M., & Dey, C. S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03993-6 · Cited by 47
Self-citation
Mechanistic insight into the role of metformin in Alzheimer's disease
Sanati, M., Aminyavari, S., Afshari, A. R., & Sahebkar, A. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120299 · Cited by 44
Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings
Khezri, M. R., Yousefi, K., Mahboubi, N., Hodaei, D., & Ghasemnejad‐Berenji, M. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114945 · Cited by 43
P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells
Varshney, P., & Dey, C. S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.035 · Cited by 42
Self-citation
The association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia
Sečník, J., Xu, H., Schwertner, E., Hammar, N., Alvarsson, M., Winblad, B. G., Eriksdotter, M., Ptacek, S. G., & Religa, D. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00934-0 · Cited by 44
Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications
Jha, N. K., Jha, N. K., Nuli, M. V., Gupta, S. K., Kanna, S., Gahtani, R. M., Hani, U., Singh, A. K., Abomughaid, M. M., Abomughayedh, A. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102224 · Cited by 43
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin
Tunc‐Ozcan, E., Wert, S. L., Lim, P. H., Ferreira, A., & Redei, E. E. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.129 · Cited by 44
Metformin in the diabetic brain: friend or foe?
Moreira, P. I. (2014) · PubMed Central · doi:10.3978/j.issn.2305-5839.2014.06.10 · Cited by 40
Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
Poor, S. R., Ettcheto, M., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Olloquequi, J., Camins, A., & Javan, M. (2021) · Pharmaceuticals · doi:10.3390/ph14090890 · Cited by 41
Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals
Coppedè, F., Grossi, E., Buscema, M., & Migliore, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074012 · Cited by 39
Metformin: An Inhibitor of mTORC1 Signaling
Melnik, B. C., & Schmitz, G. (2014) · Cited by 39
Cognition enhancing effect of the aqueous extract ofCinnamomum zeylanicumon non-transgenic Alzheimer's disease rat model: Biochemical, histological, and behavioural studies
Madhavadas, S., & Subramanian, S. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1194593 · Cited by 39
A New Perspective in Utilizing MMP-9 as a Therapeutic Target for Alzheimer’s Disease and Type 2 Diabetes Mellitus
Kaminari, A., Tsilibary, E. C., & Tzinia, A. K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180035 · Cited by 39
Role of insulin resistance in Alzheimer’s disease
Cai, Z., Xiao, M., Chang, L., & Yan, L. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9631-3 · Cited by 38
The MID1 protein is a central player during development and in disease
Krauß, S. (2015) · Frontiers in bioscience · doi:10.2741/4413 · Cited by 39
A randomized controlled trial on the efficacy, safety, and pharmacokinetics of metformin in severe traumatic brain injury
Taheri, A., Emami, M., Asadipour, E., Kasirzadeh, S., Rouini, M. R., Najafi, A., Heshmat, R., Abdollahi, M. R., & Mojtahedzadeh, M. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09366-1 · Cited by 36
Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: associations and a hypothesis
Domínguez, R. O., Pagano, M. A., Marschoff, E., González, S., Repetto, M. G., & Serra, J. A. (2014) · Neurología (English Edition) · doi:10.1016/j.nrleng.2014.10.001 · Cited by 37
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35
Cannabinoid Receptor Type 1 Agonist ACEA Improves Cognitive Deficit on STZ-Induced Neurotoxicity Through Apoptosis Pathway and NO Modulation
Crunfli, F., Vrechi, T. A. D. M., Costa, A. P., & Torrão, A. D. S. (2019) · Neurotoxicity Research · doi:10.1007/s12640-018-9991-2 · Cited by 35
Multifaceted Alzheimer’s Disease: Building a Roadmap for Advancement of Novel Therapies
Kaur, D., Behl, T., Sehgal, A., Singh, S., Sharma, N., & BUNGAU, S. G. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03415-w · Cited by 34
Beyond Amyloid
Lane, R. F., Shineman, D. W., Steele, J., Lee, L. H., & Fillit, H. M. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-394816-8.00007-6 · Cited by 35
Dementia risk in patients with type 2 diabetes: comparing metformin with no pharmacological treatment
Zheng, B., Su, B., Ahmadi‐Abhari, S., Kapogiannis, D., Tzoulaki, I., Riboli, E., & Middleton, L. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13349 · Cited by 34
Repurposing antidiabetic drugs for Alzheimer's disease: A review of preclinical and clinical evidence and overcoming challenges
Tran, J., Parekh, S., Rockcole, J., Wilson, D., & Parmar, M. S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123001 · Cited by 35
Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK
Patel, M. I., Gupta, A. K., & Dey, C. S. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70635-1 · Cited by 33
Self-citation
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus
Li, Y., ZHANG, W.-H., Liu, H., Zhou, L. I. U., & Ma, S. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30098-x · Cited by 33
New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease
Zhong, K. L., Chen, F., Hong, H., Ke, X., Lv, Y., Tang, S. S., & Zhu, Y. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0227-1 · Cited by 33
Mechanisms of ageing: growth hormone, dietary restriction, and metformin
Khan, J., Pernicova, I., Nisar, K., & Korbonits, M. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00001-3 · Cited by 34
Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions
Lee, J. H., Jahrling, J. B., Denner, L. A., & Dineley, K. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179923 · Cited by 36
Withdrawal: Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to treatment implications
Moreira, R. O., Campos, S. C., & Soldera, A. L. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2442 · Cited by 30
Retracted
SIRT2 regulates insulin sensitivity in insulin resistant neuronal cells
Arora, A., & Dey, C. S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.029 · Cited by 30
Self-citation
Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway
Zhou, M., Xu, X., Wang, H., Yang, G., Yang, M., Zhao, X., Guo, H., Song, J., Zheng, H., Zhu, Z., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901836rr · Cited by 33
Crosstalk of metabolic factors and neurogenic signaling in adult neurogenesis: Implication of metabolic regulation for mental and neurological diseases
Gao, C., Wang, Q., Chung, S. K., & Shen, J. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.02.001 · Cited by 28
Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders: drug stability, targeting efficiency, and safety
Zhang, M., Xiang, C., Niu, R., He, X., Luo, W., Liu, W., & Gu, R. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00048 · Cited by 34
Role of anti-diabetic drugs as therapeutic agents in Alzheimer's disease
Rizvi, S. M. D., Shaikh, S., Waseem, S. M. A., Shakil, S., Abuzenadah, A. M., Biswas, D., Tabrez, S. S. M., Ashraf, G. M., & Kamal, M. A. (2015) · EXCLI journal · doi:10.17179/excli2015-252 · Cited by 28
Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression
El Massry, M., Alaeddine, L. M., Ali, L., Saad, C., & Eid, A. A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200908114902 · Cited by 27
Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits
Yip, J., Chiang, G. S. H., Lee, I. C. J., Lehming-Teo, R., Dai, K., Dongol, L., Wang, L. Y.-T., Teo, D. W. X., Seah, G. T., & Lehming, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010364 · Cited by 30
From Childhood Obesity to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hyperlipidemia Through Oxidative Stress During Childhood
Accacha, S. D., Barillas, J., Srivastava, A., Ross, F., Drewes, W., Gulkarov, S., Leon, J. D., & Reiss, A. B. (2025) · Metabolites · doi:10.3390/metabo15050287 · Cited by 33
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease
Carelli‐Alinovi, C., & Misiti, F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00276 · Cited by 26
Focal adhesion kinase negatively regulates neuronal insulin resistance
Gupta, A. K., Bisht, B., & Dey, C. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.011 · Cited by 27
Self-citation
The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer’s Disease, Based on a Mechanistic Target of Rapamycin Pathway
Lin, L. (2017) · CNS Drugs · doi:10.1007/s40263-017-0431-2 · Cited by 27
The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling
Ma, X., Fang, F., Song, M., & Ma, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.081 · Cited by 26
Effect of amylin on memory and central insulin resistance in a rat model of Alzheimer’s disease
Nassar, S. Z., Badae, N. M., & Issa, Y. A. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1534244 · Cited by 26
The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Ameliorates High-fat Induced Cognitive Decline in Tauopathy Model Mice
Nakaoku, Y., Saitô, S., Yamamoto, Y., Maki, T., Takahashi, R., & Ihara, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102539 · Cited by 26
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus
Inoue, Y., Masuda, T., Misumi, Y., Ando, Y., & Ueda, M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136136 · Cited by 25
Caffeic acid improves memory impairment and brain glucose metabolism via ameliorating cerebral insulin and leptin signaling pathways in high-fat diet-induced hyperinsulinemic rats
Chang, W.-C., Kuo, P.-L., Chen, C.-W., Wu, J. S., & Shen, S. (2015) · Food Research International · doi:10.1016/j.foodres.2015.04.010 · Cited by 26
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
Briviba, M., Silamiķelis, I., Kalniņa, I., Ansone, L., Rovīte, V., Elbere, I., Radoviča-Spalviņa, I., Frīdmanis, D., Aladyeva, E., Konrāde, I., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224835 · Cited by 25
Dysmetabolism and Neurodegeneration: Trick or Treat?
Capucho, A. M., Chegão, A., Martins, F. O., Miranda, H. V., & Conde, S. V. (2022) · Nutrients · doi:10.3390/nu14071425 · Cited by 26
Diabetes Therapies for Dementia
Moran, C., Callisaya, M. L., Srikanth, V. K., & Arvanitakis, Z. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0973-4 · Cited by 24
Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease
Abdulhameed, N., Babin, A., Hansen, K. M., Weaver, R. R., Banks, W. A., Talbot, K., & Rhea, E. M. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01537-1 · Cited by 25
Metformin and the risk of dementia based on an analysis of 396,332 participants
Ji, S., Zhao, X., Zhu, R., Dong, Y., Huang, L., & Zhang, T. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221109454 · Cited by 26
Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death
Song, J., Kang, S.-M., Kim, E., Kim, C. H., Song, H., & Lee, J. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.072 · Cited by 23
Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer’s Disease
Ahlawat, A., Walia, V., & Garg, M. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-024-02706-7 · Cited by 26
Effects of Metformin on Spatial and Verbal Memory in Children with ASD and Overweight Associated with Atypical Antipsychotic Use
Aman, M. G., Hollway, J. A., Veenstra-VanderWeele, J. M., Handen, B. L., Sanders, K. B., Chan, J. G. M., Macklin, E. A., Arnold, L. E., Wong, T., Newsom, C. R., et al. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0072 · Cited by 22
Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease
Han, S.-H., & Mook‐Jung, I. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.7.893 · Cited by 23
Metformin and the risk of neurodegenerative diseases in patients with diabetes: A meta‐analysis of population‐based cohort studies
Zhang, Y., Zhang, Y., Shi, X., Han, J., Lin, B., Peng, W., Mei, Z., & Yang, L. (2022) · Diabetic Medicine · doi:10.1111/dme.14821 · Cited by 22
Metformin ameliorates the age‐related changes of d ‐galactose administration in ovariectomized mice
Fatemi, I., Heydari, S., Kaeidi, A., Shamsizadeh, A., Hakimizadeh, E., Khaluoi, A., & Allahtavakoli, M. (2018) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12364 · Cited by 21
NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance
Crunfli, F., Mazucanti, C. H., de Moraes, R. C. M., Costa, A. P., Rodrigues, A. C., Scavone, C., & Torrão, A. D. S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180284 · Cited by 21
Role of the Glyoxalase System in Alzheimer’s Disease
Jiang, L., Wang, J., Wang, Z., Huang, W., Yang, Y., Cai, Z., & Li, K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180413 · Cited by 20
Metformin reduces prion infection in neuronal cells by enhancing autophagy
Abdelaziz, D. H., Thapa, S., Abdulrahman, B., Vankuppeveld, L., & Schätzl, H. M. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.074 · Cited by 21
Activation of Wnt/β‐catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS‐1
Tian, S., Tan, S., Jia, W., Zhao, J., & Sun, X. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15277 · Cited by 20
Emerging role of Metformin in Alzheimer’s disease: A translational view
Ríos, J. A., Bórquez, J. C., Godoy, J. A., Zolezzi, J. M., Furrianca, M. C., & Inestrosa, N. C. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102439 · Cited by 21
Metformin and the PI3K/AKT signaling pathway: implications for cancer, cardiovascular, and central nervous system diseases
Ahmadabad, H. A., Panah, S. M., Ghasemnejad‐Berenji, H., Ghojavand, S., Ghasemnejad‐Berenji, M., & Khezri, M. R. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03358-3 · Cited by 20
Insulin resistance in Alzheimer's disease: signalling mechanisms and therapeutics strategies
Dahiya, M., Yadav, M., Goyal, C., & Kumar, A. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01704-2 · Cited by 22
Novel targets and therapies of metformin in dementia: old drug, new insights
Cui, W., Lv, C., Geng, P., Fu, M., Zhou, W., Xiong, M., & Li, T. X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1415740 · Cited by 21
Shared pathological pathways of Alzheimer's disease with specific comorbidities: current perspectives and interventions
Nday, C. M., Eleftheriadou, D., & Jackson, G. E. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14256 · Cited by 21
Effects of antidiabetic medications on the relationship between type 2 diabetes mellitus and cognitive impairment
Cozza, A., Chinigò, C., Filicetti, E., Greco, G. I., Lappano, R., Marinaro, C., Muglia, L., Soraci, L., Corsonello, A., Lattanzio, F., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102834 · Cited by 20
DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice
Zhuge, F., Zheng, L., Pan, Y., Ni, L., Fu, Z., Shi, J., & Ni, Y. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114689 · Cited by 19
Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway
Yang, J., Sun, Y., Xu, F., Liu, W., Mai, Y., Hayashi, T., Hattori, S., Ushiki‐Kaku, Y., Onodera, S., Tashiro, S., et al. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3414-9 · Cited by 19
Metformin: Up to Date
Sciannimanico, S. M., Grimaldi, F., Vescini, F., Pergola, G. D., Iacoviello, M., Licchelli, B., Guastamacchia, E., Giagulli, V. A., & Triggiani, V. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666190507125847 · Cited by 21
The Rationale for Insulin Therapy in Alzheimer’s Disease
Ribarič, S. (2016) · Molecules · doi:10.3390/molecules21060689 · Cited by 20
Protein Kinase C Attenuates Insulin Signalling Cascade in Insulin-Sensitive and Insulin-Resistant Neuro-2a Cells
Mishra, D., & Dey, C. S. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01377-x · Cited by 18
Self-citation
Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice
Dorvash, M., Khoshnoud, M. J., Saber, H., Dehghanian, A., Mosaddeghi, P., & Firouzabadi, N. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.002 · Cited by 18
Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend
Zhang, J., Wen, L., Zhou, Q., He, K., & Teng, L. (2020) · Cancer Management and Research · doi:10.2147/cmar.s264032 · Cited by 19
Shared Pathological Mechanisms Between Diabetes Mellitus and Neurodegenerative Diseases
Nasrolahi, A., Mahmoudi, J., Noori-Zadeh, A., Haghani, K., Bakhtiyari, S., & Darabi, S. (2019) · Current Pharmacology Reports · doi:10.1007/s40495-019-00191-8 · Cited by 20
Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs
Thomas, C., Wurzer, L., Malle, E., Ristow, M., & Madreiter‐Sokolowski, C. T. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.905261 · Cited by 18
AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake
Shah, A. K., Gupta, A. K., & Dey, C. S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.03.005 · Cited by 17
Self-citation
Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium
Jang, S., & Park, S.-H. (2018) · Chonnam Medical Journal · doi:10.4068/cmj.2018.54.1.24 · Cited by 17
Extending Arms of Insulin Resistance from Diabetes to Alzheimer’s Disease: Identification of Potential Therapeutic Targets
Gupta, S. N., Singhal, N. K., Ganesh, S., & Sandhir, R. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666181114163515 · Cited by 16
Pharmacotherapy of Alzheimer’s Disease: Current State and Future Perspectives
Korábečný, J., Zemek, F., Soukup, O., Špilovská, K., Musílek, K., Jun, D., Nepovimová, E., & Kuča, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50001-5 · Cited by 18
Is metformin a geroprotector? A peek into the current clinical and experimental data
Zajda, A., Huttunen, K. M., Sikora, J., Podsiedlik, M., & Markowicz-Piasecka, M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111350 · Cited by 16
Analysis of risk factors for depression in Alzheimer’s disease patients
Yang, H., Hong, W., Chen, L., Tao, Y. K., Peng, Z., & Zhou, H. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1730369 · Cited by 18
Could metformin be therapeutically useful in Huntington’s disease?
Tang, B. L. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0072 · Cited by 15
Long-term metformin therapy improves neurobehavioral functions and antioxidative activity after cerebral ischemia/reperfusion injury in rats
Fatemi, I., Saeed-Askari, P., Hakimizadeh, E., Kaeidi, A., Moghaddam, S. E., Pak‐Hashemi, M., & Allahtavakoli, M. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.07.015 · Cited by 15
The potential role of metformin in the treatment of Parkinson’s disease
Lu, M., Chen, H., Nie, F., Wei, X., Tao, Z., & Ma, J. (2020) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000055 · Cited by 15
Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification
Yu, K., Cheing, G. L. Y., Cheung, C., Kranz, G. S., & Cheung, K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.638861 · Cited by 14

Authors: Gupta, A., Bisht, B., & Dey, C. S.
Affiliations: National Institute of Pharmaceutical Education and Research (IN)
Corresponding author: Dey, Chinmoy Sankar
ORCID: Gupta, Amit
Bisht, Bharti
Dey, Chinmoy Sankar
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2011-05
Volume: 60
Issue: 6
Pages: 910-920
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.01.033
OpenAlex: W2001599368
Cited by: 302
References: 61
Citations by year: 2026: 10 · 2025: 11 · 2024: 29 · 2023: 15 · 2022: 26 · 2021: 25 · 2020: 25 · 2019: 19 · 2018: 27 · 2017: 20 · 2016: 22 · 2015: 16 · 2014: 23 · 2013: 16 · 2012: 15
FWCI: 12.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Department of Science and Technology, Ministry of Science and Technology, India
Council of Scientific and Industrial Research, India
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: metformin, Alzheimer's disease, type 3 diabetes, hyperinsulinemia, insulin signaling, N2a cells, insulin-sensitizing drugs, brain glucose metabolism
MeSH terms: Alzheimer Disease, Animals, Cell Line, Cholinesterases, Diabetes Mellitus, Experimental, Glucose, Hyperinsulinism, Hypoglycemic Agents, Insulin Resistance, Metformin, Neurons, Peptide Fragments, Amyloid beta-Peptides, Phosphatidylinositol 3-Kinases, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks