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Natural rewards, neuroplasticity, and non-drug addictions

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Olsen, Christopher M.·2011·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.03.010PMC PMC3139704

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Abstract

There is a high degree of overlap between brain regions involved in processing natural rewards and drugs of abuse. "Non-drug" or "behavioral" addictions have become increasingly documented in the clinic, and pathologies include compulsive activities such as shopping, eating, exercising, sexual behavior, and gambling. Like drug addiction, non-drug addictions manifest in symptoms including craving, impaired control over the behavior, tolerance, withdrawal, and high rates of relapse. These alterations in behavior suggest that plasticity may be occurring in brain regions associated with drug addiction. In this review, I summarize data demonstrating that exposure to non-drug rewards can alter neural plasticity in regions of the brain that are affected by drugs of abuse. Research suggests that there are several similarities between neuroplasticity induced by natural and drug rewards and that, depending on the reward, repeated exposure to natural rewards might induce neuroplasticity that either promotes or counteracts addictive behavior.

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Authors: Olsen, C. M.
Affiliations: Vanderbilt University (US)
Corresponding author: Olsen, Christopher M.
ORCID: Olsen, Christopher M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2011-12
Volume: 61
Issue: 7
Pages: 1109-1122
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.03.010
PMC: PMC3139704
OpenAlex: W2045365443
Cited by: 339
References: 354
Citations by year: 2026: 9 · 2025: 19 · 2024: 18 · 2023: 12 · 2022: 32 · 2021: 26 · 2020: 64 · 2019: 20 · 2018: 20 · 2017: 22 · 2016: 23 · 2015: 18 · 2014: 33 · 2013: 9 · 2012: 10
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R00DA026994, DA026994, K99DA026994)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: behavioral addiction, natural reward, neuroplasticity, drug addiction, reward processing, compulsive behavior, craving, relapse, gambling addiction, food addiction, sexual addiction, exercise addiction, compulsive buying, tolerance and withdrawal
MeSH terms: Animals, Brain, Exploratory Behavior, Food, Humans, Neuronal Plasticity, Neurons, Reinforcement, Psychology, Reward, Sexual Behavior, Sexual Behavior, Animal, Exercise, Behavior, Addictive

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