Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
Open accessAbstract
Endogenous cannabinoids (eCBs) are retrograde messengers that provide feedback inhibition of both excitatory and inhibitory transmission in brain through the activation of presynaptic CB1 receptors. Substantial evidence indicates that eCBs mediate various forms of short- and long-term plasticity in brain regions involved in the etiology of addiction. The present review provides an overview of the mechanisms through which eCBs mediate various forms of synaptic plasticity and discusses evidence that eCB-mediated plasticity is disrupted following exposure to a variety of abused substances that differ substantially in pharmacodynamic mechanism including alcohol, psychostimulants and cannabinoids. The possible involvement of dysregulated eCB signaling in maladaptive behaviors that evolve over long-term drug exposure is also discussed, with a particular focus on altered behavioral responses to drug exposure, deficient extinction of drug-related memories, increased drug craving and relapse, heightened stress sensitivity and persistent affective disruption (anxiety and depression).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuropeptide Y, nociceptin, and endocannabinoids act in opposition to brain stress systems.
“Key neurotransmitters that act in opposition to brain stress systems include neuropeptide Y, nociceptin, and endocannabinoids (tables 1, 2, circuits 10 and 11).”
From Neurobiology of addiction: a neurocircuitry analysis (2016) · cites this paper as [29]
Section 4.2 states that endocannabinoid signaling inhibits stress-induced activation of the HPA axis, supporting the endocannabinoid part of the claim. Our copy does not establish that neuropeptide Y or nociceptin act in opposition to brain stress systems; searches for both terms found no relevant passage. No page number was provided for the section. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 408 · Cited by 92
Research works printed but not linked: 1
- Valverde O Aso E Ozaita A Valdizan E Pazos A Maldonado R 2006 Depressive-like phenotype in mice lacking cannabinoid CB1 receptors European Journal of Neuropscyhopharmacology 16 S302
- Authors
- Sidhpura, N., & Parsons, L. H.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Parsons, Loren H.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 61
- Issue
- 7
- Pages
- 1070-1087
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC3176941
- OpenAlex
- W2030041532
- Semantic Scholar
- 6306d2d1bfa39ede300457d11fe985cfab4f4157
- Cited by
- 92
- References
- 408
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 15 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA020404, P50AA006420, R01AA014619, P60AA006420)
- National Institute on Drug Abuse (P20DA024194, P01DA017259)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- endocannabinoids, synaptic plasticity, addiction, CB1 receptor, retrograde signaling, drug addiction, alcohol, psychostimulants, drug craving, relapse, stress sensitivity, anxiety, depression, maladaptive behavior
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Illicit Drugs, Neurotransmitter Uptake Inhibitors, Signal Transduction, Behavior, Addictive, Presynaptic Terminals, Substance-Related Disorders, Receptor, Cannabinoid, CB1, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
