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Cited by 149Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Synaptic targets: chronic alcohol actions

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Roberto, Marisa, Varodayan, Florence P.·2017·Neuropharmacology
DOI 10.1016/j.neuropharm.2017.01.013PMC PMC5479718
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Abstract

Alcohol acts on numerous cellular and molecular targets to regulate neuronal communication within the brain. Chronic alcohol exposure and acute withdrawal generate prominent neuroadaptations at synapses, including compensatory effects on the expression, localization and function of synaptic proteins, channels and receptors. The present article reviews the literature describing the synaptic effects of chronic alcohol exposure and their relevance for synaptic transmission in the central nervous system. This review is not meant to be comprehensive, but rather to highlight the effects that have been observed most consistently and that are thought to contribute to the development of alcohol dependence and the negative aspects of withdrawal. Specifically, we will focus on the major excitatory and inhibitory neurotransmitters in the brain, glutamate and GABA, respectively, and how their neuroadaptations after chronic alcohol exposure contributes to alcohol reinforcement, dependence and withdrawal. This article is part of the Special Issue entitled "Alcoholism".

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Authors
Roberto, M., & Varodayan, F. P.
Affiliations
Scripps Research Institute (US)
Corresponding author
Roberto, Marisa
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2017-08
Volume
122
Pages
85-99
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2017.01.013
PMC
PMC5479718
OpenAlex
W2573867270
Cited by
149
References
241
Citations by year
2026: 7 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 23 · 2021: 26 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 5
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA015566, AA006420, AA016985, AA017447, AA021491, AA013498)
  • Pearson Center for Alcoholism and Addiction Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
chronic ethanol exposure, synaptic plasticity, neural adaptation, alcohol withdrawal, alcoholism, glutamate, GABA, excitatory neurotransmission, inhibitory neurotransmission, synaptic proteins, alcohol reinforcement, synaptic transmission
MeSH terms
Ethanol, Alcoholism, Animals, Brain, gamma-Aminobutyric Acid, Humans, Synaptic Transmission, Neurons, Synapses, Glutamic Acid

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