The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression
Open accessAbstract
Recent evidence indicates that psilocybin with psychological support may be effective for treating depression. Some studies have found that patients with depression show heightened amygdala responses to fearful faces and there is reliable evidence that treatment with SSRIs attenuates amygdala responses (Ma, 2015). We hypothesised that amygdala responses to emotional faces would be altered post-treatment with psilocybin. In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin. Psychological support was provided before, during and after these sessions and 19 completed fMRI scans one week prior to the first session and one day after the second and last. Neutral, fearful and happy faces were presented in the scanner and analyses focused on the amygdala. Group results revealed rapid and enduring improvements in depressive symptoms post psilocybin. Increased responses to fearful and happy faces were observed in the right amygdala post-treatment, and right amygdala increases to fearful versus neutral faces were predictive of clinical improvements at 1-week. Psilocybin with psychological support was associated with increased amygdala responses to emotional stimuli, an opposite effect to previous findings with SSRIs. This suggests fundamental differences in these treatments' therapeutic actions, with SSRIs mitigating negative emotions and psilocybin allowing patients to confront and work through them. Based on the present results, we propose that psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression, enabling patients to reconnect with their emotions. TRIAL REGISTRATION: ISRCTN, number ISRCTN14426797. This article is part of the Special Issue entitled 'Psychedelics: New Doors, Altered Perceptions'.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The amygdala has been found to show greater responsiveness to emotional faces 1 day after psilocybin consumption and greater responsiveness to fearful versus neutral faces was related to improved depressive symptoms 1 week post-intervention [36].”
From The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol (2022) · cites this paper as [36]
The cited source says what the claim attributes to it.
In the citing paper
“The amygdala has been found to show greater responsiveness to emotional faces 1 day after psilocybin consumption and greater responsiveness to fearful versus neutral faces was related to improved depressive symptoms 1 week post-intervention [36].”
From The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol (2022) · cites this paper as [36]
In the citing paper
“However, increased amygdala reactivity toward fearful faces was measured prior to any psychological integration work (31).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [31]
In the citing paper
“amygdala reactivity was increased in response to fearful faces in treatment-resistant depressed patients the morning after psilocybin administration (31).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Cortical Surface-Based Analysis
Dale, A. M., Fischl, B., & Sereno, M. I. (1999) · NeuroImage · doi:10.1006/nimg.1998.0395 · Cited by 10,910
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429
The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods
Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P. J., L. Whitwell, J., Ward, C., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21049 · Cited by 4,347
Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829
Manual for the state-trait anxiety inventory (form Y) : "self-evaluation questionnaire"
Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (1970) · Consulting Psychologists Press eBooks · Cited by 2,352
Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675513 · Cited by 2,201 · cited 3×
“, 2015), end of life anxiety (Gasser et al., 2014a; Griffiths et al., 2016; Grob et al., 2011; Ross et al., 2016), obsessive compulsive disorder (Moreno et al.”
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011 · cited 1×
“The amygdala is a complex subcortical structure that is sensitive to emotional stimuli (Janak and Tye, 2015; Sergerie et al., 2008).”
Cited by
Sorted by citations
Items 201–229 of 229
Tura, A. (2024) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10519
Zeifman, R. J. (2024) · doi:10.32920/26052859.v1 · Cited by 1
Ramarushton, B. (2024) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc2332656
Medical Use of Cannabinoids and Psychedelic Compounds
Inserra, A., Gregorio, D. D., & Gobbi, G. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_141
Mattu, J., & Sullivan, J. A. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780192898371.003.0007
Liu, Q., Ma, Q., Sun, Q., & Huang, X. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1397375
Lasch, A., Schweikert, T., Dora, E., Kolb, T., Schurig, H. L., & Walther, A. (2025) · Nervenheilkunde · doi:10.1055/a-2517-1621
Wall, M. B., & Carhart-Harris, R. L. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.04.013
Self-citationRecent advances in rapid-acting antidepressants
Pan, L., He, Y., Wang, G., & Shen, J. (2025) · Scientia Sinica Chimica · doi:10.1360/ssc-2025-0157
Behavioural investigations of psilocybin in non-human animals 1962–2021: A scoping review
Shore, R., Dobson, K., Thomson, N., Barnim, N., Bergman, H. P., Rideout, K., McKeown, S., Olmstead, M. C., Goldie, C. E., & Dumont, É. C. (2025) · Journal of Psychedelic Studies · doi:10.1556/2054.2025.00364 · Cited by 5
Zhang, X., Liu, D.-N., Miao, Q.-S., Cai, X., Zong, L.-X., Hou, Y.-K., & Xiong, J. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174099
McConnell, P., Raffety, J., Li, A., Steinberg, E., Rahim, S., Valtierra, C., Gazzaley, A. H., Carhart-Harris, R. L., & Pasquini, L. (2025) · Research Square · doi:10.21203/rs.3.rs-7625999/v1
Self-citationMedicinal Mushrooms and Mental Disorders: How Mushrooms Affect Anxiety and Depression
Tarki, A., Hajikarim‐Hamedani, A., Rassa, S., & Khosravi, S. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2774-8_6
Diehl, V. J., Calder, A. E., & Hasler, G. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251397306
Reward-related neural activity after low doses of LSD in participants with depressed mood
Glazer, J. E., Molla, H. M., Lee, R., Nusslock, R., & de Wit, H. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811251405686
High hopes? Precision psychedelic addiction medicine
Zafar, R. R., Kleine, P., Kurtin, D. L., Wall, M. B., & Erritzøe, D. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1681795
Self-citationThe neurophenomenology of a self-induced transcendental visionary state: A case study
Bella, G. A. D., Picatto, A. V., Rial, D. S. G., Cukier, S., Torres, G. F., Catanzariti, M., Mateos, D. M., Lamberti, P. W., Cardeña, E., & Barttfeld, P. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121784
Magnani, L., Ghirotto, L., Fesce, F., Re, T., Tanzi, S., Amerio, A., & Costanza, A. (2026) · BMJ Supportive & Palliative Care · doi:10.1136/spcare-2025-005689
Psilocibina en depresión: mecanismos neurobiológicos y cambios cognitivos
Arias, A. V., Ramírez, M. C., López, A. H., & Becerra-Hernández, L. V. (2026) · Acta neurológica colombiana · doi:10.22379/anc.v42i1.1926
Predictors of the Effectiveness of Psychedelics in Treating Depression—A Scoping Review
Chmiel, J., & Rybakowski, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052202 · Cited by 1
Orlowski, P., Domagalik, A., & Bola, M. (2026) · Human Brain Mapping · doi:10.1002/hbm.70522
Raihan, A. (2026) · Journal of Behavioral and Cognitive Therapy · doi:10.1016/j.jbct.2026.100571
Jóźwiak-Bębenista, M., Stasiak, A., Sienkiewicz, M., Kwiatkowski, P. A., & Kowalczyk, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104229 · Cited by 1
Wang, H., Liao, W., Li, Y., Guo, A., Liu, Z., Guo, X., Wang, K., Zheng, Y., Wang, Z., Wang, W., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03830
Frick, A., Blest‐Hopley, G., Grin, M., Erritzøe, D., Nutt, D., & Carhart-Harris, R. L. (2026) · Psychopharmacology · doi:10.21203/rs.3.rs-9880403/v1
Self-citationSmith, S. A., Mohammad, H., Lee, L. H. N., Dennett, L., Smith, S., Burback, L., Winkler, O., Greenshaw, A. J., Jetly, R., Kennedy, S. H., et al. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07110-y
A Case of Acute Mania and Rhabdomyolysis Associated With Long-Term, Daily Psilocybin Use
Wells, D. A., Hayes, L., & Walker, K. (2026) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002262
Hogg, D. E., Romanos, J., Albiez, J., Hofer, C., Wicki, S., Argunşah, A. Ö., Sigrist, H., Thomann, J., Luethi, D., Vollenweider, F. X., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1918182
Clinical Evidence on Psilocybin and Its Representation in Media Reporting
Madden, K., Flood, B., Kashir, I., Ahmad, R., Ali, H., Petranker, R., MacKillop, J., & Adili, A. F. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.38843
Metadata
- Authors
- Roseman, L., Demetriou, L., Wall, M. B., Nutt, D. J., & Carhart-Harris, R. L.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Roseman, Leor
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 142
- Pages
- 263-269
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2781340150
- Cited by
- 230
- References
- 57
- Citations by year
- 2026: 30 · 2025: 34 · 2024: 38 · 2023: 30 · 2022: 34 · 2021: 27 · 2020: 18 · 2019: 10 · 2018: 8
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuropharmacology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Imperial College Scholarship Scheme
- Imanova
- Edmund J Safra Foundation (P17264)
- Alex Mosely Charitable Trust (G30444)
- MRC clinical development scheme (MR/J00460X/1)
- Alex Mosley Charitable Trust
- COMPASS group (I30006)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- psilocybin, treatment-resistant depression, amygdala, emotional face processing, fearful faces, happy faces, psychological support, selective serotonin reuptake inhibitors, antidepressant mechanism, emotional responsiveness
- MeSH terms
- Facial Recognition, Adult, Amygdala, Antidepressive Agents, Brain Mapping, Combined Modality Therapy, Emotions, Female, Hallucinogens, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prognosis, Psilocybin, Psychotherapy, Depressive Disorder, Treatment-Resistant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
