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Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry
Open accessAbstract
The hippocampus is the brain structure of highest and earliest structural alteration in Alzheimer's disease (AD). New developments in neuroimaging methods recently made it possible to assess the respective involvement of the different hippocampal subfields by mapping atrophy on a 3D hippocampal surface view. In this longitudinal study on patients with mild cognitive impairment (MCI), we used such an approach to map the profile of hippocampal atrophy and its progression over an 18-month follow-up period in rapid converters to AD and "non-converters" compared to age-matched controls. For the sake of comparison, we also assessed the profile of hippocampal atrophy associated with AD and with increasing age in a healthy control population ranging from young adult to elderly. We found major involvement of the lateral part of the superior hippocampus mainly corresponding to the CA1 subfield in MCI and AD while increasing age was mainly associated with subiculum atrophy in the healthy population. Moreover, the CA1 subfield also showed highest atrophy rates during follow-up, in both rapid converters and "non-converters" although increased effects were observed in the former group. This study emphasizes the differences between normal aging and AD processes leading to hippocampal atrophy, pointing to a specific AD-related CA1 involvement while subiculum atrophy would represent a normal aging process. Our findings also suggest that the degree of hippocampal atrophy, more than its spatial localization, predicts rapid conversion to AD in patients with MCI.
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“Using a variety of neuroimaging approaches such as radial atrophy (Frisoni et al., 2006), large-deformation high-dimensional brain mapping (Wang et al., 2003), voxel-based morphometry (Chételat et al., 2008) or manual delineation (Mueller et al., 2010), the predominance of atrophy in CA1 (and to a lesser extent in the subiculum) in patients with clinical AD or aMCI has already been shown in vivo.”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Chételat et al., 2008
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References 48 · Cited by 143
Research works printed but not linked: 1
- Cardebat, 1990, Évocation lexicale formelle et sémantique chez des sujets normaux: Performances et dynamiques de production en fonction du sexe, de l’âge et du niveau d’étude, Acta Neurologica Belgica, 90, 207
Metadata
- Authors
- Chételat, G., Fouquet, M., Kalpouzos, G., Denghien, I., De la Sayette, V., Viader, F., Mézenge, F., Landeau, B., Baron, J. C., Eustache, F., & Desgranges, B.
- Affiliations
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- University of Cambridge (GB)
- Corresponding author
- Chételat, G.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 46
- Issue
- 6
- Pages
- 1721-1731
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2029800492
- Semantic Scholar
- 272c3c9ad2115c028f9b28fa10d13ce7b18d8986
- Cited by
- 143
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 5 · 2013: 5 · 2012: 12
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal atrophy, Alzheimer's disease, mild cognitive impairment, conversion to Alzheimer's disease, CA1 subfield, subiculum, normal aging, hippocampal subfields, atrophy progression, voxel-based morphometry
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Brain Mapping, Cognition Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Disease Progression, Imaging, Three-Dimensional
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