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Cited by 13Dementia and Cognitive Impairment ResearchMemory Processes and InfluencesCognitive Functions and Memory

Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease

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Salmon, David P., Heindel, William C., Hamilton, Joanne M., Vincent Filoteo, J., Cidambi, Varun, Hansen, Lawrence A., Masliah, Eliezer, Galasko, Douglas·2015·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2015.07.014PMC PMC4752828
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Abstract

Evidence from patients with amnesia suggests that recognition memory span tasks engage both long-term memory (i.e., secondary memory) processes mediated by the diencephalic-medial temporal lobe memory system and working memory processes mediated by fronto-striatal systems. Thus, the recognition memory span task may be particularly effective for detecting memory deficits in disorders that disrupt both memory systems. The presence of unique pathology in fronto-striatal circuits in Dementia with Lewy Bodies (DLB) compared to AD suggests that performance on the recognition memory span task might be differentially affected in the two disorders even though they have quantitatively similar deficits in secondary memory. In the present study, patients with autopsy-confirmed DLB or AD, and Normal Control (NC) participants, were tested on separate recognition memory span tasks that required them to retain increasing amounts of verbal, spatial, or visual object (i.e., faces) information across trials. Results showed that recognition memory spans for verbal and spatial stimuli, but not face stimuli, were lower in patients with DLB than in those with AD, and more impaired relative to NC performance. This was despite similar deficits in the two patient groups on independent measures of secondary memory such as the total number of words recalled from long-term storage on the Buschke Selective Reminding Test. The disproportionate vulnerability of recognition memory span task performance in DLB compared to AD may be due to greater fronto-striatal involvement in DLB and a corresponding decrement in cooperative interaction between working memory and secondary memory processes. Assessment of recognition memory span may contribute to the ability to distinguish between DLB and AD relatively early in the course of disease.

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  • Working memory serves as the basis of other higher order cognitive processes including recognition memory, which is mediated by mPFC function.

    “Among numerous cognitive domains, working memory serves as the basis of other higher order cognitive processes including but not limited to recognition memory (27–29), which is mediated by mPFC function.”

    From Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine (2022) · cites this paper as [29]

    The Discussion says the recognition memory span task requires working-memory processes interacting with secondary memory, supporting a link between working memory and recognition memory. It describes fronto-striatal and medial temporal lobe systems, but does not say recognition memory is mediated by mPFC function or that working memory is the basis of higher-order cognitive processes generally. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 40

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Cited by

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Authors
Salmon, D. P., Heindel, W. C., Hamilton, J. M., Vincent Filoteo, J., Cidambi, V., Hansen, L. A., Masliah, E., & Galasko, D.
Affiliations
  • University of California San Diego (US)
  • Brown University (US)
Corresponding author
Salmon, David P.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2015-08
Volume
75
Pages
548-555
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2015.07.014
PMC
PMC4752828
OpenAlex
W877763428
Cited by
13
References
2
Citations by year
2025: 3 · 2024: 1 · 2022: 3 · 2020: 4 · 2019: 1 · 2016: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • NIH (AG12963, AG05131, NS049298)
  • Shiley-Marcos Alzheimer’s Disease Research Center
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
dementia with Lewy bodies, Alzheimer's disease, working memory, secondary memory, frontostriatal circuits, face recognition (cognition), differential diagnosis, early detection of dementia, memory impairment
MeSH terms
Facial Recognition, Aged, Alzheimer Disease, Brain, Humans, Memory, Short-Term, Mental Status Schedule, Neuropsychological Tests, Mental Recall, Space Perception, Speech Perception, Lewy Body Disease, Recognition, Psychology

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