Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus
Open accessAbstract
The mammalian target of rapamycin (mTOR) pathway is important for regulating protein translation. The present study characterized the role of mTOR-dependent translation in the dorsal hippocampus (DH) during the consolidation and reconsolidation of contextual fear memory. We first showed that fear conditioning resulted in increased phosphorylation of p70s6 kinase (p70s6K) in the DH and that infusion of the mTOR inhibitor rapamycin (RAP) into the DH immediately after training disrupted formation of long-term contextual fear memory. Additionally we showed that p70s6K was activated after retrieval of a previously stored fear memory, and inhibition of mTOR by DH infusion of RAP blocked the reconsolidation of contextual fear memory. Together these results demonstrate that within the DH translational control through the mTOR pathway is important for consolidation as well as the stability of fear memory after retrieval.
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mTORC1 contributes to reconsolidation of fear and spatial recognition memories.
“as well as to reconsolidation of fear and spatial recognition memories16-20”
From Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse (2013) · cites this paper as [20]
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References 47 · Cited by 110
- Authors
- Gafford, G. M., Parsons, R. G., & Helmstetter, F. J.
- Affiliations
- University of Wisconsin–Milwaukee (US)
- Corresponding author
- Gafford, G.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 182
- Pages
- 98-104
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3087706
- OpenAlex
- W2073243965
- Cited by
- 110
- References
- 47
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 9 · 2017: 13 · 2016: 7 · 2015: 9 · 2014: 12 · 2013: 12 · 2012: 8
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH069558, R01MH069558)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- contextual fear memory, memory consolidation, memory reconsolidation, mTOR signaling, mRNA translation, dorsal hippocampus, p70 S6 kinase, rapamycin, fear conditioning, memory retrieval
- MeSH terms
- Animals, Fear, Learning, Male, Memory, Protein Biosynthesis, Rats, Long-Evans, Rats, CA3 Region, Hippocampal, TOR Serine-Threonine Kinases
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