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Cited by 42Epilepsy research and treatmentIon Transport and Channel RegulationIon channel regulation and function

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Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models

Funck, V.R., Ribeiro, L.R., Pereira, L.M., de Oliveira, C.V., Grigoletto, J., Della-Pace, I.D., Fighera, M.R., Royes, L.F.F., Furian, A.F., Larrick, J.W., Oliveira, M.S.·2015·Neuroscience
DOI 10.1016/j.neuroscience.2015.04.031
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Abstract

Epilepsy is a life-shortening brain disorder affecting approximately 1% of the worldwide population. Most epilepsy patients are refractory to currently available antiepileptic drugs (AEDs). Knowledge about the mechanisms underlying seizure activity and probing for new AEDs is fundamental to the discovery of new therapeutic strategies. Brain Na(+), K(+)-ATPase activity contributes to the maintenance of the electrochemical gradients underlying neuronal resting and action potentials as well as the uptake and release of neurotransmitters. Accordingly, a decrease of Na(+), K(+)-ATPase increases neuronal excitability and may predispose to appearing of seizure activity. In the present study, we tested the hypothesis that activation of Na(+), K(+)-ATPase activity with a specific antibody (DRRSAb) raised against a regulatory site in the α subunit would decrease seizure susceptibility. We found that incubation of hippocampal homogenates with DRRSAb (1 μM) increased total and α1 Na(+), K(+)-ATPase activities. A higher concentration (3 μM) increased total, α1 and α2/α3 Na(+), K(+)-ATPase activities. Intrahippocampal injection of DRRSAb decreased the susceptibility of post status epilepticus animals to pentylenetetrazol (PTZ)-induced myoclonic seizures. In contrast, administration of DRRSAb into the hippocampus of naïve animals facilitated the appearance of PTZ-induced seizures. Quantitative analysis of hippocampal electroencephalography (EEG) recordings revealed that DRRSAb increased the…

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  • The abluminal sodium pump (Na+-K+-ATPase) is a key regulator of sodium influx into the brain and potassium efflux from the brain, keeping high concentration of Na+ and low levels of K+ in brain interstitial fluid.

    “The abluminal sodium pump (Na + -K + -ATPase) is a key regulator of sodium (Na + ) influx into the brain and potassium (K + ) efflux from the brain, which keeps high concentration of Na + and low levels of K + in brain ISF (188, 624).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [188]

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Metadata

Authors
Funck, V. R., Ribeiro, L. R., Pereira, L. M., de Oliveira, C. V., Grigoletto, J., Della-Pace, I. D., Fighera, M. R., Royes, L. F. F., Furian, A. F., Larrick, J. W., & Oliveira, M. S.
Affiliations
  • Universidade Federal de Santa Maria (BR)
  • Panorama Research (United States) (US)
Corresponding author
Oliveira, M.S.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-07
Volume
298
Pages
171-179
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2015.04.031
OpenAlex
W2023107947
Cited by
42
References
1
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • FAPERGS (ARD 11/1630-1, PRONEM 11/2082-4)
  • CNPq (471666/2013-0)
  • CAPES
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
Na+/K+-ATPase, epilepsy, seizure susceptibility, pentylenetetrazole-induced seizures, status epilepticus, hippocampus, neuronal excitability, delta oscillations, hippocampal EEG, antiepileptic drug targets
MeSH terms
Sodium-Potassium-Exchanging ATPase, Animals, Antibodies, Anticonvulsants, Convulsants, Disease Models, Animal, Electroencephalography, Hippocampus, Male, Mice, Inbred C57BL, Pentylenetetrazole, Pilocarpine, Status Epilepticus, Time Factors, Gene Expression Regulation, Enzymologic, Statistics, Nonparametric, Rats, Brain Waves

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