Cited by 218Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Impact of anxiety on prefrontal cortex encoding of cognitive flexibility
Open accessPark, Junchol, Moghaddam, Bita·2017·Neuroscience
Abstract
Anxiety often is studied as a stand-alone construct in laboratory models. But in the context of coping with real-life anxiety, its negative impacts extend beyond aversive feelings and involve disruptions in ongoing goal-directed behaviors and cognitive functioning. Critical examples of cognitive constructs affected by anxiety are cognitive flexibility and decision making. In particular, anxiety impedes the ability to shift flexibly between strategies in response to changes in task demands, as well as the ability to maintain a strategy in the presence of distractors. The brain region most critically involved in behavioral flexibility is the prefrontal cortex (PFC), but little is known about how anxiety impacts PFC encoding of internal and external events that are critical for flexible behavior. Here we review animal and human neurophysiological and neuroimaging studies implicating PFC neural processing in anxiety-induced deficits in cognitive flexibility. We then suggest experimental and analytical approaches for future studies to gain a better mechanistic understanding of impaired cognitive inflexibility in anxiety and related disorders.
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The prefrontal cortex is involved in processing anxiety, which can interfere with goal-directed behavior and cognitive performance.
“The prefrontal cortex is involved in processing anxiety, which can interfere with goal-directed behavior and cognitive performance (Park and Moghaddam, 2017).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Park and Moghaddam, 2017
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- Adhikari A Topiwala MA Gordon JA 2010 Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety Neuron 65 257 269 20152131 PMC2822726
- Anderson MH Hardcastle C Munafo MR Robinson ES 2012 Evaluation of a novel translational task for assessing emotional biases in different species Cogn Affect Behav Neurosci 12 373 381 22183974
- Anderson SW Bechara A Damasio H Tranel D Damasio AR 1999 Impairment of social and moral behavior related to early damage in human prefrontal cortex Nature neuroscience 2 1032 1037 10526345
- Ansari TL Derakshan N Richards A 2008 Effects of anxiety on task switching: evidence from the mixed antisaccade task Cognitive, affective & behavioral neuroscience 8 229 238 18814460
- Asaad WF Rainer G Miller EK 2000 Task-specific neural activity in the primate prefrontal cortex J Neurophysiol 84 451 459 10899218
- Baeg EH Kim YB Jang J Kim HT Mook-Jung I Jung MW 2001 Fast spiking and regular spiking neural correlates of fear conditioning in the medial prefrontal cortex of the rat Cerebral cortex 11 441 451 11313296
- Bar-Haim Y Lamy D Pergamin L Bakermans-Kranenburg MJ van IMH 2007 Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study Psychological bulletin 133 1 24 17201568
- Bechara A Tranel D Damasio H 2000 Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions Brain 123 Pt 11 2189 2202 11050020
- Bechara A Tranel D Damasio H Damasio AR 1996 Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex Cerebral cortex 6 215 225 8670652
- Bertolino A Arciero G Rubino V Latorre V De Candia M Mazzola V Blasi G Caforio G Hariri A Kolachana B Nardini M Weinberger DR Scarabino T 2005 Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style Biol Psychiatry 57 1517 1525 15953488
- Birrell JM Brown VJ 2000 Medial frontal cortex mediates perceptual attentional set shifting in the rat The Journal of neuroscience: the official journal of the Society for Neuroscience 20 4320 4324 10818167 PMC6772641
- Bishop SJ 2009 Trait anxiety and impoverished prefrontal control of attention Nature neuroscience 12 92 98 19079249
- Bissonette GB Schoenbaum G Roesch MR Powell EM 2015 Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex Biol Psychiatry 77 454 464 25193243 PMC4312743
- Bondi CO Rodriguez G Gould GG Frazer A Morilak DA 2008 Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 33 320 331 17406647
- Bradberry CW Lory JD Roth RH 1991 The anxiogenic beta-carboline FG 7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis Journal of neurochemistry 56 748 752 1993892
- Briggman KL Abarbanel HD Kristan WB Jr 2005 Optical imaging of neuronal populations during decision-making Science 307 896 901 15705844
- Burgos-Robles A Vidal-Gonzalez I Quirk GJ 2009 Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure The Journal of neuroscience: the official journal of the Society for Neuroscience 29 8474 8482 19571138 PMC2733220
- Buschman TJ Denovellis EL Diogo C Bullock D Miller EK 2012 Synchronous oscillatory neural ensembles for rules in the prefrontal cortex Neuron 76 838 846 23177967 PMC3907768
- Butts KA Weinberg J Young AH Phillips AG 2011 Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function Proceedings of the National Academy of Sciences of the United States of America 108 18459 18464 22032926 PMC3215005
- Cardin JA Carlen M Meletis K Knoblich U Zhang F Deisseroth K Tsai LH Moore CI 2009 Driving fastspiking cells induces gamma rhythm and controls sensory responses Nature 459 663 667 19396156 PMC3655711
- Cho KK Hoch R Lee AT Patel T Rubenstein JL Sohal VS 2015 Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/−) mice Neuron 85 1332 1343 25754826 PMC4503262
- Christopoulos GI Tobler PN Bossaerts P Dolan RJ Schultz W 2009 Neural correlates of value, risk, and risk aversion contributing to decision making under risk The Journal of neuroscience: the official journal of the Society for Neuroscience 29 12574 12583 19812332 PMC2794196
- Cisler JM Koster EH 2010 Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review Clin Psychol Rev 30 203 216 20005616 PMC2814889
- Clark L Bechara A Damasio H Aitken MR Sahakian BJ Robbins TW 2008 Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making Brain 131 1311 1322 18390562 PMC2367692
- Cole BJ Hillmann M Seidelmann D Klewer M Jones GH 1995 Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat Psychopharmacology 121 118 126 8539336
- Courtin J Chaudun F Rozeske RR Karalis N Gonzalez-Campo C Wurtz H Abdi A Baufreton J Bienvenu TC Herry C 2014 Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression Nature 505 92 96 24256726
- Darrah JM Stefani MR Moghaddam B 2008 Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm Behavioural pharmacology 19 225 234 18469540 PMC2910418
- Davis M 2006 Neural systems involved in fear and anxiety measured with fear-potentiated startle The American psychologist 61 741 756 17115806
- Dazzi L Ladu S Spiga F Vacca G Rivano A Pira L Biggio G 2002 Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats Synapse 43 70 77 11746735
- Dias R Robbins TW Roberts AC 1996 Dissociation in prefrontal cortex of affective and attentional shifts Nature 380 69 72 8598908
- Dorow R 1987 FG 7142 and its anxiety-inducing effects in humans British journal of clinical pharmacology 23 781 782 3606939 PMC1386178
- Durstewitz D Vittoz NM Floresco SB Seamans JK 2010 Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning Neuron 66 438 448 20471356
- Duvarci S Pare D 2014 Amygdala microcircuits controlling learned fear Neuron 82 966 980 24908482 PMC4103014
- Egner T Hirsch J 2005 Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information Nature neuroscience 8 1784 1790 16286928
- Evans AK Abrams JK Bouwknecht JA Knight DM Shekhar A Lowry CA 2006 The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex Pharmacol Biochem Behav 84 266 274 16784772
- Evans AK Lowry CA 2007 Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects CNS drug reviews 13 475 501 18078430 PMC6494137
- Fecteau S Knoch D Fregni F Sultani N Boggio P Pascual-Leone A 2007 Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study The Journal of neuroscience: the official journal of the Society for Neuroscience 27 12500 12505 18003828 PMC6673338
- Felix-Ortiz AC Beyeler A Seo C Leppla CA Wildes CP Tye KM 2013 BLA to vHPC inputs modulate anxiety-related behaviors Neuron 79 658 664 23972595 PMC4205569
- Floresco SB Block AE Tse MT 2008 Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure Behavioural brain research 190 85 96 18359099
- Fries P 2005 A mechanism for cognitive dynamics: neuronal communication through neuronal coherence Trends in cognitive sciences 9 474 480 16150631
- Fries P 2015 Rhythms for Cognition: Communication through Coherence Neuron 88 220 235 26447583 PMC4605134
- Fuster JM Bodner M Kroger JK 2000 Cross-modal and cross-temporal association in neurons of frontal cortex Nature 405 347 351 10830963
- George SA Rodriguez-Santiago M Riley J Abelson JL Floresco SB Liberzon I 2015 Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder Behavioural brain research 286 256 264 25746511
- Gillan CM Kosinski M Whelan R Phelps EA Daw ND 2016 Characterizing a psychiatric symptom dimension related to deficits in goal-directed control Elife 5 PMC4786435 26928075
- Giorgetta C Grecucci A Zuanon S Perini L Balestrieri M Bonini N Sanfey AG Brambilla P 2012 Reduced risk-taking behavior as a trait feature of anxiety Emotion 12 1373 1383 22775123
- Gunaydin LA Grosenick L Finkelstein JC Kauvar IV Fenno LE Adhikari A Lammel S Mirzabekov JJ Airan RD Zalocusky KA Tye KM Anikeeva P Malenka RC Deisseroth K 2014 Natural neural projection dynamics underlying social behavior Cell 157 1535 1551 24949967 PMC4123133
- Hartley CA Phelps EA 2012 Anxiety and decision-making Biol Psychiatry 72 113 118 22325982 PMC3864559
- Harvey CD Coen P Tank DW 2012 Choice-specific sequences in parietal cortex during a virtualnavigation decision task Nature 484 62 68 22419153 PMC3321074
- Herry C Ciocchi S Senn V Demmou L Muller C Luthi A 2008 Switching on and off fear by distinct neuronal circuits Nature 454 600 606 18615015
- Hoshi E Shima K Tanji J 1998 Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex J Neurophysiol 80 3392 3397 9862940
- Jackson ME Moghaddam B 2006 Distinct patterns of plasticity in prefrontal cortex neurons that encode slow and fast responses to stress The European journal of neuroscience 24 1702 1710 17004934 PMC2881693
- Karalis N Dejean C Chaudun F Khoder S Rozeske RR Wurtz H Bagur S Benchenane K Sirota A Courtin J Herry C 2016 4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior Nature neuroscience PMC4843971 26878674
- Karlsson MP Tervo DG Karpova AY 2012 Network resets in medial prefrontal cortex mark the onset of behavioral uncertainty Science 338 135 139 23042898
- Kerns JG Cohen JD MacDonald AW 3rd Cho RY Stenger VA Carter CS 2004 Anterior cingulate conflict monitoring and adjustments in control Science 303 1023 1026 14963333
- Kim S Lee D 2011 Prefrontal cortex and impulsive decision making Biological psychiatry 69 1140 1146 20728878 PMC2991430
- Kim SY Adhikari A Lee SY Marshel JH Kim CK Mallory CS Lo M Pak S Mattis J Lim BK Malenka RC Warden MR Neve R Tye KM Deisseroth K 2013 Diverging neural pathways assemble a behavioural state from separable features in anxiety Nature 496 219 223 23515158 PMC6690364
- Knoch D Gianotti LR Pascual-Leone A Treyer V Regard M Hohmann M Brugger P 2006 Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior J Neurosci 26 6469 6472 16775134 PMC6674035
- Koizumi A Tanaka A Imai H Hiramatsu S Hiramoto E Sato T de Gelder B 2011 The effects of anxiety on the interpretation of emotion in the face-voice pairs Exp Brain Res 213 275 282 21487700
- Kumar S Hultman R Hughes D Michel N Katz BM Dzirasa K 2014 Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress Nat Commun 5 4537 25072279 PMC4148151
- Lammel S Lim BK Ran C Huang KW Betley MJ Tye KM Deisseroth K Malenka RC 2012 Input-specific control of reward and aversion in the ventral tegmental area Nature 491 212 217 23064228 PMC3493743
- Lesting J Narayanan RT Kluge C Sangha S Seidenbecher T Pape HC 2011 Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction PLoS One 6 e21714 21738775 PMC3125298
- Li CS Chao HH Lee TW 2009 Neural correlates of speeded as compared with delayed responses in a stop signal task: an indirect analog of risk taking and association with an anxiety trait Cereb Cortex 19 839 848 18678764 PMC2722793
- Likhtik E Stujenske JM Topiwala MA Harris AZ Gordon JA 2014 Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety Nature neuroscience 17 106 113 24241397 PMC4035371
- Lin LC Sibille E 2015 Somatostatin, neuronal vulnerability and behavioral emotionality Molecular psychiatry 20 377 387 25600109 PMC4355106
- Lyche P Jonassen R Stiles TC Ulleberg P Landro NI 2010 Cognitive Control Functions in Unipolar Major Depression with and without Co-Morbid Anxiety Disorder Front Psychiatry 1 149 21423456 PMC3059619
- Ma L Hyman JM Lindsay AJ Phillips AG Seamans JK 2014 Differences in the emergent coding properties of cortical and striatal ensembles Nature neuroscience 17 1100 1106 24974796 PMC4978541
- Maner JK Gailliot MT Menzel AJ Kunstman JW 2012 Dispositional anxiety blocks the psychological effects of power Pers Soc Psychol Bull 38 1383 1395 22854791
- Mante V Sussillo D Shenoy KV Newsome WT 2013 Context-dependent computation by recurrent dynamics in prefrontal cortex Nature 503 78 84 24201281 PMC4121670
- McAlonan K Brown VJ 2003 Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat Behavioural brain research 146 97 103 14643463
- McClure SM Laibson DI Loewenstein G Cohen JD 2004 Separate neural systems value immediate and delayed monetary rewards Science 306 503 507 15486304
- Meyer-Lindenberg A Buckholtz JW Kolachana B ARH Pezawas L Blasi G Wabnitz A Honea R Verchinski B Callicott JH Egan M Mattay V Weinberger DR 2006 Neural mechanisms of genetic risk for impulsivity and violence in humans Proc Natl Acad Sci U S A 103 6269 6274 16569698 PMC1458867
- Mogg K Bradley BP 1998 A cognitive-motivational analysis of anxiety Behav Res Ther 36 809 848 9701859
- Moghaddam B Roth RH Bunney BS 1990 Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: comparison to the striatum Neuroscience 36 669 676 2234405
- Morgan MA LeDoux JE 1995 Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats Behavioral neuroscience 109 681 688 7576212
- Morrison SE Salzman CD 2009 The convergence of information about rewarding and aversive stimuli in single neurons J Neurosci 29 11471 11483 19759296 PMC2782596
- Murphy BL Arnsten AF Goldman-Rakic PS Roth RH 1996a Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys Proceedings of the National Academy of Sciences of the United States of America 93 1325 1329 8577763 PMC40079
- Murphy BL Arnsten AF Jentsch JD Roth RH 1996b Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment The Journal of neuroscience: the official journal of the Society for Neuroscience 16 7768 7775 8922432 PMC6579090
- Nagano-Saito A Leyton M Monchi O Goldberg YK He Y Dagher A 2008 Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task The Journal of neuroscience: the official journal of the Society for Neuroscience 28 3697 3706 18385328 PMC6671089
- Namburi P Beyeler A Yorozu S Calhoon GG Halbert SA Wichmann R Holden SS Mertens KL Anahtar M Felix-Ortiz AC Wickersham IR Gray JM Tye KM 2015 A circuit mechanism for differentiating positive and negative associations Nature 520 675 678 25925480 PMC4418228
- Nyhus E Barcelo F 2009 The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update Brain and cognition 71 437 451 19375839
- Park J Wood J Bondi C Del Arco A Moghaddam B 2016 Anxiety Evokes Hypofrontality and Disrupts Rule-Relevant Encoding by Dorsomedial Prefrontal Cortex Neurons The Journal of neuroscience: the official journal of the Society for Neuroscience 36 3322 3335 26985040 PMC4792942
- Pellow S File SE 1985 The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response Physiol Behav 35 587 590 2999846
- Pellow S File SE 1986 Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plusmaze: a novel test of anxiety in the rat Pharmacol Biochem Behav 24 525 529 2871560
- Perugi G Del Carlo A Benvenuti M Fornaro M Toni C Akiskal K Dell’Osso L Akiskal H 2011 Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia? J Affect Disord 133 600 606 21665290
- Pezawas L Meyer-Lindenberg A Drabant EM Verchinski BA Munoz KE Kolachana BS Egan MF Mattay VS Hariri AR Weinberger DR 2005 5-HTTLPR polymorphism impacts human cingulateamygdala interactions: a genetic susceptibility mechanism for depression Nat Neurosci 8 828 834 15880108
- Pitman RK Rasmusson AM Koenen KC Shin LM Orr SP Gilbertson MW Milad MR Liberzon I 2012 Biological studies of post-traumatic stress disorder Nature reviews Neuroscience 13 769 787 23047775 PMC4951157
- Raghunathan R Pham MT 1999 All Negative Moods Are Not Equal: Motivational Influences of Anxiety and Sadness on Decision Making Organ Behav Hum Decis Process 79 56 77 10388609
- Ragozzino ME Kim J Hassert D Minniti N Kiang C 2003 The contribution of the rat prelimbicinfralimbic areas to different forms of task switching Behav Neurosci 117 1054 1065 14570554
- Raposo D Kaufman MT Churchland AK 2014 A category-free neural population supports evolving demands during decision-making Nature neuroscience 17 1784 1792 25383902 PMC4294797
- Rich EL Shapiro M 2009 Rat prefrontal cortical neurons selectively code strategy switches The Journal of neuroscience: the official journal of the Society for Neuroscience 29 7208 7219 19494143 PMC3229282
- Richards A French CC Calder AJ Webb B Fox R Young AW 2002 Anxiety-related bias in the classification of emotionally ambiguous facial expressions Emotion 2 273 287 12899360
- Rigotti M Ben Dayan Rubin D Morrison SE Salzman CD Fusi S 2010 Attractor concretion as a mechanism for the formation of context representations Neuroimage 52 833 847 20100580 PMC2891574
- Roesch MR Olson CR 2004 Neuronal activity related to reward value and motivation in primate frontal cortex Science 304 307 310 15073380
- Schoenbaum G Roesch MR Stalnaker TA Takahashi YK 2009 A new perspective on the role of the orbitofrontal cortex in adaptive behaviour Nature reviews Neuroscience 10 885 892 19904278 PMC2835299
- Shen Q Lal R Luellen BA Earnheart JC Andrews AM Luscher B 2010 gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression Biological psychiatry 68 512 520 20579975 PMC2930197
- Shin LM Whalen PJ Pitman RK Bush G Macklin ML Lasko NB Orr SP McInerney SC Rauch SL 2001 An fMRI study of anterior cingulate function in posttraumatic stress disorder Biological psychiatry 50 932 942 11750889
- Simon NW Wood J Moghaddam B 2015 Action-outcome relationships are represented differently by medial prefrontal and orbitofrontal cortex neurons during action execution J Neurophysiol 114 3374 3385 26467523 PMC4868377
- Sirota A Montgomery S Fujisawa S Isomura Y Zugaro M Buzsaki G 2008 Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm Neuron 60 683 697 19038224 PMC2640228
- Soumier A Sibille E 2014 Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice Neuropsychopharmacology 39 2252 2262 24690741 PMC4104344
- Stefani MR Groth K Moghaddam B 2003 Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability Behav Neurosci 117 728 737 12931958
- Stefani MR Moghaddam B 2010 Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade Eur J Pharmacol 639 26 32 20371234 PMC3359134
- Stokes MG Kusunoki M Sigala N Nili H Gaffan D Duncan J 2013 Dynamic coding for cognitive control in prefrontal cortex Neuron 78 364 375 23562541 PMC3898895
- Sylvers P Lilienfeld SO LaPrairie JL 2011 Differences between trait fear and trait anxiety: implications for psychopathology Clin Psychol Rev 31 122 137 20817337
- Wallis JD Anderson KC Miller EK 2001 Single neurons in prefrontal cortex encode abstract rules Nature 411 953 956 11418860
- White IM Wise SP 1999 Rule-dependent neuronal activity in the prefrontal cortex Exp Brain Res 126 315 335 10382618
- Authors
- Park, J., & Moghaddam, B.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Moghaddam, Bita
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 345
- Pages
- 193-202
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC5159328
- OpenAlex
- W2442982730
- Cited by
- 218
- References
- 137
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 29 · 2023: 34 · 2022: 37 · 2021: 33 · 2020: 21 · 2019: 14 · 2018: 9 · 2017: 6 · 2016: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIMH
- Pittsburgh Greenhouse Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- anxiety, cognitive flexibility, prefrontal cortex, behavioral flexibility, strategy switching, distractor interference, decision-making, neural coding, anxiety disorders, neuroimaging, neurophysiology
- MeSH terms
- Animals, Anxiety, Cognition, Humans, Prefrontal Cortex, Executive Function
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