A tale of two circuits: CCK NTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions

Roman, Carolyn W.; Sloat, Stephanie R.; Palmiter, Richard D.

doi:10.1016/j.neuroscience.2017.06.049

A tale of two circuits: CCK NTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions

Cholecystokinin (CCK)-expressing neurons within the nucleus of the solitary tract (CCKNTS) are responsive to satiety signals and their chemogenetic activation suppresses appetite. Optogenetic activation of CCKNTS axon terminals within either the parabrachial nucleus (PBN) or the paraventricular n…